Proximal and distal control for ligand binding in neuroglobin: role of the CD loop and evidence for His64 gating

por Exertier, Cécile, Milazzo, Lisa, Freda, Ida, Montemiglio, Linda Celeste, Scaglione, Antonella, Cerutti, Gabriele, Parisi, Giacomo, Anselmi, Massimiliano, Smulevich, Giulietta, Savino, Carmelinda, Vallone, Beatrice
Publicado 2019

Subcellular localization of the five members of the human steroid 5α-reductase family

por Scaglione, Antonella, Montemiglio, Linda Celeste, Parisi, Giacomo, Asteriti, Italia Anna, Bruni, Renato, Cerutti, Gabriele, Testi, Claudia, Savino, Carmelinda, Mancia, Filippo, Lavia, Patrizia, Vallone, Beatrice
Publicado 2017

Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate

por Parisi, Giacomo, Freda, Ida, Exertier, Cécile, Cecchetti, Cristina, Gugole, Elena, Cerutti, Gabriele, D’Auria, Lucia, Macone, Alberto, Vallone, Beatrice, Savino, Carmelinda, Montemiglio, Linda Celeste
Publicado 2020

Cryo-EM structure of the SARS-CoV-2 Omicron spike

por Cerutti, Gabriele, Guo, Yicheng, Liu, Lihong, Liu, Liyuan, Zhang, Zhening, Luo, Yang, Huang, Yiming, Wang, Harris H., Ho, David D., Sheng, Zizhang, Shapiro, Lawrence
Publicado 2022

Increased Resistance of SARS-CoV-2 Variant P.1 to Antibody Neutralization

por Wang, Pengfei, Casner, Ryan G., Nair, Manoj S., Wang, Maple, Yu, Jian, Cerutti, Gabriele, Liu, Lihong, Kwong, Peter D., Huang, Yaoxing, Shapiro, Lawrence, Ho, David D.
Publicado 2021

Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization

por Wang, Pengfei, Casner, Ryan G., Nair, Manoj S., Wang, Maple, Yu, Jian, Cerutti, Gabriele, Liu, Lihong, Kwong, Peter D., Huang, Yaoxing, Shapiro, Lawrence, Ho, David D.
Publicado 2021

Point Mutations at a Key Site Alter the Cytochrome P450 OleP Structural Dynamics

por Montemiglio, Linda Celeste, Gugole, Elena, Freda, Ida, Exertier, Cécile, D’Auria, Lucia, Chen, Cheng Giuseppe, Nardi, Alessandro Nicola, Cerutti, Gabriele, Parisi, Giacomo, D’Abramo, Marco, Savino, Carmelinda, Vallone, Beatrice
Publicado 2021

Crystal structure and functional characterization of an oligosaccharide dehydrogenase from Pycnoporus cinnabarinus provides insights into fungal breakdown of lignocellulose

por Cerutti, Gabriele, Gugole, Elena, Montemiglio, Linda Celeste, Turbé-Doan, Annick, Chena, Dehbia, Navarro, David, Lomascolo, Anne, Piumi, François, Exertier, Cécile, Freda, Ida, Vallone, Beatrice, Record, Eric, Savino, Carmelinda, Sciara, Giuliano
Publicado 2021

Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies

por Cerutti, Gabriele, Rapp, Micah, Guo, Yicheng, Bahna, Fabiana, Bimela, Jude, Reddem, Eswar R., Yu, Jian, Wang, Pengfei, Liu, Lihong, Huang, Yaoxing, Ho, David D., Kwong, Peter D., Sheng, Zizhang, Shapiro, Lawrence
Publicado 2021

Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

por Cerutti, Gabriele, Guo, Yicheng, Wang, Pengfei, Nair, Manoj S., Wang, Maple, Huang, Yaoxing, Yu, Jian, Liu, Lihong, Katsamba, Phinikoula S., Bahna, Fabiana, Reddem, Eswar R., Kwong, Peter D., Ho, David D., Sheng, Zizhang, Shapiro, Lawrence
Publicado 2021

Probing the Role of Murine Neuroglobin CDloop–D-Helix Unit in CO Ligand Binding and Structural Dynamics

por Exertier, Cécile, Sebastiani, Federico, Freda, Ida, Gugole, Elena, Cerutti, Gabriele, Parisi, Giacomo, Montemiglio, Linda Celeste, Becucci, Maurizio, Viappiani, Cristiano, Bruno, Stefano, Savino, Carmelinda, Zamparelli, Carlotta, Anselmi, Massimiliano, Abbruzzetti, Stefania, Smulevich, Giulietta, Vallone, Beatrice
Publicado 2022

Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class

por Rapp, Micah, Guo, Yicheng, Reddem, Eswar R., Yu, Jian, Liu, Lihong, Wang, Pengfei, Cerutti, Gabriele, Katsamba, Phinikoula, Bimela, Jude S., Bahna, Fabiana A., Mannepalli, Seetha M., Zhang, Baoshan, Kwong, Peter D., Huang, Yaoxing, Ho, David D., Shapiro, Lawrence, Sheng, Zizhang
Publicado 2021

Biodistribution PET/CT Study of Hemoglobin-DFO-(89)Zr Complex in Healthy and Lung Tumor-Bearing Mice

por Kiraga, Łukasz, Cerutti, Gabriele, Braniewska, Agata, Strzemecki, Damian, Sas, Zuzanna, Boffi, Alberto, Savino, Carmelinda, Montemiglio, Linda Celeste, Turnham, Daniel, Seaton, Gillian, Bonamore, Alessandra, Clarkson, Richard, Dabkowski, Adam M., Paisey, Stephen J., Taciak, Bartłomiej, Kucharzewska, Paulina, Rygiel, Tomasz P., Król, Magdalena
Publicado 2020

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

por Wang, Pengfei, Casner, Ryan G., Nair, Manoj S., Yu, Jian, Guo, Yicheng, Wang, Maple, Chan, Jasper F.-W., Cerutti, Gabriele, Iketani, Sho, Liu, Lihong, Sheng, Zizhang, Chen, Zhiwei, Yuen, Kwok-Yung, Kwong, Peter D., Huang, Yaoxing, Shapiro, Lawrence, Ho, David D.
Publicado 2021

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

por Wang, Pengfei, Casner, Ryan G., Nair, Manoj S., Yu, Jian, Guo, Yicheng, Wang, Maple, Chan, Jasper F.-W., Cerutti, Gabriele, Iketani, Sho, Liu, Lihong, Sheng, Zizhang, Chen, Zhiwei, Yuen, Kwok-Yung, Kwong, Peter D., Huang, Yaoxing, Shapiro, Lawrence, Ho, David D.
Publicado 2021

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

por Cerutti, Gabriele, Guo, Yicheng, Zhou, Tongqing, Gorman, Jason, Lee, Myungjin, Rapp, Micah, Reddem, Eswar R., Yu, Jian, Bahna, Fabiana, Bimela, Jude, Huang, Yaoxing, Katsamba, Phinikoula S., Liu, Lihong, Nair, Manoj S., Rawi, Reda, Olia, Adam S., Wang, Pengfei, Zhang, Baoshan, Chuang, Gwo-Yu, Ho, David D., Sheng, Zizhang, Kwong, Peter D., Shapiro, Lawrence
Publicado 2021

Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization

por Glögl, Matthias, Friedrich, Nikolas, Cerutti, Gabriele, Lemmin, Thomas, Kwon, Young D., Gorman, Jason, Maliqi, Liridona, Mittl, Peer R. E., Hesselman, Maria C., Schmidt, Daniel, Weber, Jacqueline, Foulkes, Caio, Dingens, Adam S., Bylund, Tatsiana, Olia, Adam S., Verardi, Raffaello, Reinberg, Thomas, Baumann, Nicolas S., Rusert, Peter, Dreier, Birgit, Shapiro, Lawrence, Kwong, Peter D., Plückthun, Andreas, Trkola, Alexandra
Publicado 2023

Gating movements and ion permeation in HCN4 pacemaker channels

por Saponaro, Andrea, Bauer, Daniel, Giese, M. Hunter, Swuec, Paolo, Porro, Alessandro, Gasparri, Federica, Sharifzadeh, Atiyeh Sadat, Chaves-Sanjuan, Antonio, Alberio, Laura, Parisi, Giacomo, Cerutti, Gabriele, Clarke, Oliver B., Hamacher, Kay, Colecraft, Henry M., Mancia, Filippo, Hendrickson, Wayne A., Siegelbaum, Steven A., DiFrancesco, Dario, Bolognesi, Martino, Thiel, Gerhard, Santoro, Bina, Moroni, Anna
Publicado 2021

Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains

por Zhou, Tongqing, Tsybovsky, Yaroslav, Gorman, Jason, Rapp, Micah, Cerutti, Gabriele, Chuang, Gwo-Yu, Katsamba, Phinikoula S., Sampson, Jared M., Schön, Arne, Bimela, Jude, Boyington, Jeffrey C., Nazzari, Alexandra, Olia, Adam S., Shi, Wei, Sastry, Mallika, Stephens, Tyler, Stuckey, Jonathan, Teng, I-Ting, Wang, Pengfei, Wang, Shuishu, Zhang, Baoshan, Friesner, Richard A., Ho, David D., Mascola, John R., Shapiro, Lawrence, Kwong, Peter D.
Publicado 2020

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

por Liu, Lihong, Iketani, Sho, Guo, Yicheng, Casner, Ryan G., Reddem, Eswar R., Nair, Manoj S., Yu, Jian, Chan, Jasper F-W., Wang, Maple, Cerutti, Gabriele, Li, Zhiteng, Morano, Nicholas C., Castagna, Candace D., Corredor, Laura, Chu, Hin, Yuan, Shuofeng, Poon, Vincent Kwok-Man, Chan, Chris Chun-Sing, Chen, Zhiwei, Luo, Yang, Cunningham, Marcus, Chavez, Alejandro, Yin, Michael T., Perlin, David S., Tsuji, Moriya, Yuen, Kwok-Yung, Kwong, Peter D., Sheng, Zizhang, Huang, Yaoxing, Shapiro, Lawrence, Ho, David D.
Publicado 2022