Exploring the origins of nucleation

por Zoltowska, Katarzyna Marta, Chávez-Gutiérrez, Lucía
Publicado 2021

Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site

por Chen, Shu-Yu, Feilen, Lukas P., Chávez-Gutiérrez, Lucía, Steiner, Harald, Zacharias, Martin
Publicado 2023

APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release

por Koch, Matthias, Enzlein, Thomas, Chen, Shu‐Yu, Petit, Dieter, Lismont, Sam, Zacharias, Martin, Hopf, Carsten, Chávez‐Gutiérrez, Lucía
Publicado 2023

TrkA-mediated endocytosis of p75-CTF prevents cholinergic neuron death upon γ-secretase inhibition

por Franco, María Luisa, García-Carpio, Irmina, Comaposada-Baró, Raquel, Escribano-Saiz, Juan J, Chávez-Gutiérrez, Lucía, Vilar, Marçal
Publicado 2021

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration

por Acx, Hermien, Serneels, Lutgarde, Radaelli, Enrico, Muyldermans, Serge, Vincke, Cécile, Pepermans, Elise, Müller, Ulrike, Chávez‐Gutiérrez, Lucía, De Strooper, Bart
Publicado 2017

Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ‐secretase modulators

por Petit, Dieter, Hitzenberger, Manuel, Lismont, Sam, Zoltowska, Katarzyna Marta, Ryan, Natalie S, Mercken, Marc, Bischoff, François, Zacharias, Martin, Chávez‐Gutiérrez, Lucía
Publicado 2019

Enzyme–substrate interface targeting by imidazole‐based γ‐secretase modulators activates γ‐secretase and stabilizes its interaction with APP

por Petit, Dieter, Hitzenberger, Manuel, Koch, Matthias, Lismont, Sam, Zoltowska, Katarzyna Marta, Enzlein, Thomas, Hopf, Carsten, Zacharias, Martin, Chávez‐Gutiérrez, Lucía
Publicado 2022

The dynamic conformational landscape of γ-secretase

por Elad, Nadav, De Strooper, Bart, Lismont, Sam, Hagen, Wim, Veugelen, Sarah, Arimon, Muriel, Horré, Katrien, Berezovska, Oksana, Sachse, Carsten, Chávez-Gutiérrez, Lucía
Publicado 2015

Aβ profiles generated by Alzheimer’s disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset

por Petit, Dieter, Fernández, Sara Gutiérrez, Zoltowska, Katarzyna Marta, Enzlein, Thomas, Ryan, Natalie S., O’Connor, Antoinette, Szaruga, Maria, Hill, Elizabeth, Vandenberghe, Rik, Fox, Nick C., Chávez-Gutiérrez, Lucía
Publicado 2022

The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue

por Willumsen, Nanet, Arber, Charles, Lovejoy, Christopher, Toombs, Jamie, Alatza, Argyro, Weston, Philip S J, Chávez-Gutiérrez, Lucia, Hardy, John, Zetterberg, Henrik, Fox, Nick C, Ryan, Natalie S, Lashley, Tammaryn, Wray, Selina
Publicado 2022

Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease

por Szaruga, Maria, Veugelen, Sarah, Benurwar, Manasi, Lismont, Sam, Sepulveda-Falla, Diego, Lleo, Alberto, Ryan, Natalie S., Lashley, Tammaryn, Fox, Nick C., Murayama, Shigeo, Gijsen, Harrie, De Strooper, Bart, Chávez-Gutiérrez, Lucía
Publicado 2015

Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

por Escamilla-Ayala, Abril Angélica, Sannerud, Ragna, Mondin, Magali, Poersch, Karin, Vermeire, Wendy, Paparelli, Laura, Berlage, Caroline, Koenig, Marcelle, Chavez-Gutierrez, Lucia, Ulbrich, Maximilian H, Munck, Sebastian, Mizuno, Hideaki, Annaert, Wim
Publicado 2020

Prodromal Alzheimer’s Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer’s Pathology

por de Vidania, Silvia, Palomares-Perez, Irene, Frank-García, Ana, Saito, Takashi, Saido, Takaomi C., Draffin, Jonathan, Szaruga, María, Chávez-Gutierrez, Lucía, Calero, Miguel, Medina, Miguel, Guix, Francesc X., Dotti, Carlos G.
Publicado 2020

Alzheimer’s disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling

por Zoltowska, Katarzyna Marta, Das, Utpal, Lismont, Sam, Enzlein, Thomas, Maesako, Masato, Houser, Mei CQ, Franco, María Luisa, Moreira, Diana Gomes, Karachentsev, Dmitry, Becker, Ann, Hopf, Carsten, Vilar, Marçal, Berezovska, Oksana, Mobley, William, Chávez-Gutiérrez, Lucía
Publicado 2023

Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease

por Guix, Francesc X, Wahle, Tina, Vennekens, Kristel, Snellinx, An, Chávez-Gutiérrez, Lucía, Ill-Raga, Gerard, Ramos-Fernandez, Eva, Guardia-Laguarta, Cristina, Lleó, Alberto, Arimon, Muriel, Berezovska, Oksana, Muñoz, Francisco J, Dotti, Carlos G, De Strooper, Bart
Publicado 2012

A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer’s disease

por Sepulveda-Falla, Diego, Chavez-Gutierrez, Lucia, Portelius, Erik, Vélez, Jorge I., Dujardin, Simon, Barrera-Ocampo, Alvaro, Dinkel, Felix, Hagel, Christian, Puig, Berta, Mastronardi, Claudio, Lopera, Francisco, Hyman, Bradley T., Blennow, Kaj, Arcos-Burgos, Mauricio, de Strooper, Bart, Glatzel, Markus
Publicado 2020

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

por Chávez-Gutiérrez, Lucía, Bammens, Leen, Benilova, Iryna, Vandersteen, Annelies, Benurwar, Manasi, Borgers, Marianne, Lismont, Sam, Zhou, Lujia, Van Cleynenbreugel, Simon, Esselmann, Hermann, Wiltfang, Jens, Serneels, Lutgarde, Karran, Eric, Gijsen, Harrie, Schymkowitz, Joost, Rousseau, Frederic, Broersen, Kerensa, De Strooper, Bart
Publicado 2012

Identification and characterization of Nanobodies targeting the EphA4 receptor

por Schoonaert, Lies, Rué, Laura, Roucourt, Bart, Timmers, Mieke, Little, Susan, Chávez-Gutiérrez, Lucía, Dewilde, Maarten, Joyce, Peter, Curnock, Adam, Weber, Peter, Haustraete, Jurgen, Hassanzadeh-Ghassabeh, Gholamreza, De Strooper, Bart, Van Den Bosch, Ludo, Van Damme, Philip, Lemmens, Robin, Robberecht, Wim
Publicado 2017

Plasma amyloid-β ratios in autosomal dominant Alzheimer’s disease: the influence of genotype

por O'Connor, Antoinette, Pannee, Josef, Poole, Teresa, Arber, Charles, Portelius, Erik, Swift, Imogen J, Heslegrave, Amanda J, Abel, Emily, Willumsen, Nanet, Rice, Helen, Weston, Philip S J, Ryan, Natalie S, Polke, James M, Nicholas, Jennifer M, Mead, Simon, Wray, Selina, Chávez-Gutiérrez, Lucía, Frost, Chris, Blennow, Kaj, Zetterberg, Henrik, Fox, Nick C
Publicado 2021

Spastic paraplegia preceding PSEN1‐related familial Alzheimer's disease

por Chelban, Viorica, Breza, Marianthi, Szaruga, Maria, Vandrovcova, Jana, Murphy, David, Lee, Chia‐Ju, Alikhwan, Sondos, Bourinaris, Thomas, Vavougios, George, Ilyas, Muhammad, Halim, Sobia Ahsan, Al‐Harrasi, Ahmed, Kartanou, Chrisoula, Ronald, Coras, Blumcke, Ingmar, Alexoudi, Athanasia, Gatzonis, Stylianos, Stefanis, Leonidas, Karadima, Georgia, Wood, Nicholas W., Chávez‐Gutiérrez, Lucía, Hardy, John, Houlden, Henry, Koutsis, Georgios
Publicado 2021