Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity

por Penman, Sophie L., Carter, Alice S., Chadwick, Amy E.
Publicado 2020

Developing In Vitro Models to Define the Role of Direct Mitochondrial Toxicity in Frequently Reported Drug-Induced Rhabdomyolysis

por Bin Dayel, Faten F., Alfirevic, Ana, Chadwick, Amy E.
Publicado 2023

The mitochondrial paradox

por Penman, Sophie L, Jensen, Rebecca L, Kiy, Robyn T, Chadwick, Amy E
Publicado 2020

The Role of Mitochondrial DNA Variation in Drug Response: A Systematic Review

por Jones, Samantha W., Ball, Amy L., Chadwick, Amy E., Alfirevic, Ana
Publicado 2021

Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention

por Yang, Mingming, Chadwick, Amy E., Dart, Caroline, Kamishima, Tomoko, Quayle, John M.
Publicado 2017

A morphometric analysis of the infant calvarium and dura

por Breisch, Eric, Haas, Elisabeth A., Masoumi, Homeyra, Chadwick, Amy E., Krous, Henry F.
Publicado 2010

Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells

por Ball, Amy L., Kamalian, Laleh, Alfirevic, Ana, Lyon, Jonathan J., Chadwick, Amy E.
Publicado 2016

Pulmonary arterial medial smooth muscle thickness in sudden infant death syndrome: an analysis of subsets of 73 cases

por Krous, Henry F., Haas, Elisabeth, Hampton, Catherine F., Chadwick, Amy E., Stanley, Christina, Langston, Claire
Publicado 2009

Using the health belief model to identify communication opportunities to prevent Chagas disease in Southern Ecuador

por Patterson, Nelson M., Bates, Benjamin R., Chadwick, Amy E., Nieto-Sanchez, Claudia, Grijalva, Mario J.
Publicado 2018

Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells

por Penman, Sophie L., Sharma, Parveen, Aerts, Hélène, Park, B. Kevin, Weaver, Richard J., Chadwick, Amy E.
Publicado 2019

The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury

por Ball, Amy Louise, Jolly, Carol E, Lennon, Mark G, Lyon, Jonathan J, Alfirevic, Ana, Chadwick, Amy E
Publicado 2023

Modelling changes in glutathione homeostasis as a function of quinone redox metabolism

por Kelly, Ross A., Leedale, Joseph, Calleja, Dominic, Enoch, Steven J., Harrell, Andy, Chadwick, Amy E., Webb, Steven
Publicado 2019

Modelling the impact of changes in the extracellular environment on the cytosolic free NAD(+)/NADH ratio during cell culture

por Kelly, Ross A., Leedale, Joseph, Harrell, Andy, Beard, Daniel A., Randle, Laura E., Chadwick, Amy E., Webb, Steven D.
Publicado 2018

Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers

por Ball, Amy L., Bloch, Katarzyna M., Rainbow, Lucille, Liu, Xuan, Kenny, John, Lyon, Jonathan J., Gregory, Richard, Alfirevic, Ana, Chadwick, Amy E.
Publicado 2021

Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection

por Brennan, Sean, Esposito, Simona, Abdelaziz, Muhammad I. M., Martin, Christopher A., Makwana, Samir, Sims, Mark W., Squire, Iain B., Sharma, Parveen, Chadwick, Amy E., Rainbow, Richard D.
Publicado 2022

Sudden unexpected death in early childhood: general observations in a series of 151 cases: Part 1 of the investigations of the San Diego SUDC Research Project

por Hefti, Marco M., Kinney, Hannah C., Cryan, Jane B., Haas, Elisabeth A., Chadwick, Amy E., Crandall, Laura A., Trachtenberg, Felicia L., Armstrong, Dawna D., Grafe, Marjorie, Krous, Henry F.
Publicado 2016

The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine

por Jolly, Carol E., Douglas, Oisin, Kamalian, Laleh, Jenkins, Rosalind E., Beckett, Alison J., Penman, Sophie L., Williams, Dominic P., Monshouwer, Mario, Simic, Damir, Snoeys, Jan, Park, B. Kevin, Chadwick, Amy E.
Publicado 2020

Safety perspectives on presently considered drugs for the treatment of COVID‐19

por Penman, Sophie L., Kiy, Robyn T., Jensen, Rebecca L., Beoku‐Betts, Christopher, Alfirevic, Ana, Back, David, Khoo, Saye H., Owen, Andrew, Pirmohamed, Munir, Park, B. Kevin, Meng, Xiaoli, Goldring, Christopher E., Chadwick, Amy E.
Publicado 2020

CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program

por Thaventhiran, Thilipan, Wong, Wai, Alghanem, Ahmad F., Alhumeed, Naif, Aljasir, Mohammad A., Ramsey, Simeon, Sethu, Swaminathan, Yeang, Han Xian Aw, Chadwick, Amy E., Cross, Michael, Webb, Steven D., Djouhri, Laiche, Ball, Christina, Stebbings, Richard, Sathish, Jean G.
Publicado 2019

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

por Heslop, James A., Rowe, Cliff, Walsh, Joanne, Sison-Young, Rowena, Jenkins, Roz, Kamalian, Laleh, Kia, Richard, Hay, David, Jones, Robert P., Malik, Hassan Z., Fenwick, Stephen, Chadwick, Amy E., Mills, John, Kitteringham, Neil R., Goldring, Chris E. P., Kevin Park, B.
Publicado 2016