Scyl1 Facilitates Nuclear tRNA Export in Mammalian Cells by Acting at the Nuclear Pore Complex

por Chafe, Shawn C., Mangroo, Dev
Publicado 2010

Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development

por Chafe, Shawn C, Dedhar, Shoukat
Publicado 2015

Nuclear-Cytoplasmic Trafficking of NTF2, the Nuclear Import Receptor for the RanGTPase, Is Subjected to Regulation

por Chafe, Shawn C., Pierce, Jacqueline B., Mangroo, Dev
Publicado 2012

Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction

por McDonald, Paul C., Chafe, Shawn C., Dedhar, Shoukat
Publicado 2016

BSCI-22 DETERMINING THE EFFECT OF NOVEL SMALL MOLECULE DRUGS AGAINST THE MIGRATION OF BRAIN METASTASIS INITIATING CELLS (BMICS)

por Mobilio, Daniel, Kieliszek, Agata, Chafe, Shawn, Venugopal, Chitra, Singh, Sheila
Publicado 2022

Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside

por McDonald, Paul C., Chafe, Shawn C., Supuran, Claudiu T., Dedhar, Shoukat
Publicado 2022

Nutrient stress does not cause retrograde transport of cytoplasmic tRNA to the nucleus in evolutionarily diverse organisms

por Chafe, Shawn C., Pierce, Jacqueline B., Eswara, Manoja B. K., McGuire, Andrew T., Mangroo, Dev
Publicado 2011

A Carbonic Anhydrase IX/SLC1A5 Axis Regulates Glutamine Metabolism Dependent Ferroptosis in Hypoxic Tumor Cells

por Venkateswaran, Geetha, McDonald, Paul C., Chafe, Shawn C., Brown, Wells S., Gerbec, Zachary J., Awrey, Shannon J., Parker, Seth J., Dedhar, Shoukat
Publicado 2023

Granulocyte Colony Stimulating Factor Expression in Breast Cancer and Its Association with Carbonic Anhydrase IX and Immune Checkpoints

por Chafe, Shawn C., Riaz, Nazia, Burugu, Samantha, Gao, Dongxia, Leung, Samuel C. Y., Lee, Anna F., Lee, Cheng-Han, Dedhar, Shoukat, Nielsen, Torsten O.
Publicado 2021

Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer

por Brown, Wells S., McDonald, Paul C., Nemirovsky, Oksana, Awrey, Shannon, Chafe, Shawn C., Schaeffer, David F., Li, Jinyang, Renouf, Daniel J., Stanger, Ben Z., Dedhar, Shoukat
Publicado 2020

BSBM-09 IN VIVO CRISPR ACTIVATION SCREEN IDENTIFIES ß-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) AS A DRIVER OF NON-SMALL CELL LUNG CANCER BRAIN METASTASIS

por Chafe, Shawn, Zhai, Kui, Aghaei, Nikoo, Miletic, Petar, Brown, Kevin, Mobilio, Daniel, Venugopal, Chitra, Kieliszek, Agata, Hynds, Robert, Lam, Fred, Moffat, Jason, Swanton, Charles, Bao, Shideng, Singh, Sheila
Publicado 2023

Dual Antigen T Cell Engagers Targeting CA9 as an Effective Immunotherapeutic Modality for Targeting CA9 in Solid Tumors

por Tatari, Nazanin, Zhang, Xiaoyu, Chafe, Shawn C., McKenna, Dillon, Lawson, Keith A., Subapanditha, Minomi, Shaikh, Muhammad Vaseem, Seyfrid, Mathieu, Savage, Neil, Venugopal, Chitra, Moffat, Jason, Singh, Sheila K.
Publicado 2022

Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking

por Brasher, Megan I., Chafe, Shawn C., McDonald, Paul C., Nemirovsky, Oksana, Gorshtein, Genya, Gerbec, Zachary J., Brown, Wells S., Grafinger, Olivia R., Marchment, Matthew, Matus, Esther, Dedhar, Shoukat, Coppolino, Marc G.
Publicado 2022

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors

por Chafe, Shawn C., Vizeacoumar, Frederick S., Venkateswaran, Geetha, Nemirovsky, Oksana, Awrey, Shannon, Brown, Wells S., McDonald, Paul C., Carta, Fabrizio, Metcalfe, Andrew, Karasinska, Joanna M., Huang, Ling, Muthuswamy, Senthil K., Schaeffer, David F., Renouf, Daniel J., Supuran, Claudiu T., Vizeacoumar, Franco J., Dedhar, Shoukat
Publicado 2021

An HLA-G/SPAG9/STAT3 axis promotes brain metastases

por Bassey-Archibong, Blessing Iquo, Rajendra Chokshi, Chirayu, Aghaei, Nikoo, Kieliszek, Agata Monika, Tatari, Nazanin, McKenna, Dillon, Singh, Mohini, Kalpana Subapanditha, Minomi, Parmar, Arun, Mobilio, Daniel, Savage, Neil, Lam, Fred, Tokar, Tomas, Provias, John, Lu, Yu, Chafe, Shawn Christopher, Swanton, Charles, Hynds, Robert Edward, Venugopal, Chitra, Singh, Sheila Kumari
Publicado 2023

Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX

por Sheff, Joey G., Kelly, John F., Robotham, Anna, Sulea, Traian, Malenfant, Félix, L’Abbé, Denis, Duchesne, Mélanie, Pelletier, Alex, Lefebvre, Jean, Acel, Andrea, Parat, Marie, Gosselin, Mylene, Wu, Cunle, Fortin, Yves, Baardsnes, Jason, Van Faassen, Henk, Awrey, Shannon, Chafe, Shawn C., McDonald, Paul C., Dedhar, Shoukat, Lenferink, Anne E.G.
Publicado 2021

Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX

por Lenferink, Anne E.G., McDonald, Paul C., Cantin, Christiane, Grothé, Suzanne, Gosselin, Mylene, Baardsnes, Jason, Banville, Myriam, Lachance, Paul, Robert, Alma, Cepero-Donates, Yuneivy, Radinovic, Stevo, Salois, Patrick, Parat, Marie, Oamari, Hafida, Dulude, Annie, Patel, Mehul, Lafrance, Martin, Acel, Andrea, Bousquet-Gagnon, Nathalie, L’Abbé, Denis, Pelletier, Alex, Malenfant, Félix, Jaramillo, Maria, O’Connor-Mccourt, Maureen, Wu, Cunle, Durocher, Yves, Duchesne, Mélanie, Gadoury, Christine, Marcil, Anne, Fortin, Yves, Paul-Roc, Beatrice, Acchione, Maurizio, Chafe, Shawn C., Nemirovsky, Oksana, Lau, Joseph, Bénard, Francois, Dedhar, Shoukat
Publicado 2021

Mutations in the Profilin 1 Gene Cause Familial Amyotrophic Lateral Sclerosis

por Wu, Chi-Hong, Fallini, Claudia, Ticozzi, Nicola, Keagle, Pamela J., Sapp, Peter C., Piotrowska, Katarzyna, Lowe, Patrick, Koppers, Max, McKenna-Yasek, Diane, Baron, Desiree M., Kost, Jason E., Gonzalez-Perez, Paloma, Fox, Andrew D., Adams, Jenni, Taroni, Franco, Tiloca, Cinzia, Leclerc, Ashley Lyn, Chafe, Shawn C., Mangroo, Dev, Moore, Melissa J., Zitzewitz, Jill A., Xu, Zuo-Shang, van den Berg, Leonard H., Glass, Jonathan D., Siciliano, Gabriele, Cirulli, Elizabeth T., Goldstein, David B., Salachas, Francois, Meininger, Vincent, Rossoll, Wilfried, Ratti, Antonia, Gellera, Cinzia, Bosco, Daryl A., Bassell, Gary J., Silani, Vincenzo, Drory, Vivian E., Brown, Robert H., Landers, John E.
Publicado 2012