Is There an Interplay Between the Functional Domains of IRAP?

por Vear, Anika, Gaspari, Tracey, Thompson, Philip, Chai, Siew Yeen
Publicado 2020

Editorial: Physiological, Pathological Roles and Pharmacology of Insulin Regulated Aminopeptidase

por Chai, Siew Yeen, Gutiérrez-de-Terán, Hugo, Stratikos, Efstratios
Publicado 2021

Development of a sandwich ELISA to detect circulating, soluble IRAP as a potential disease biomarker

por Vear, Anika, Thalmann, Claudia, Youngs, Kristina, Hannan, Natalie, Gaspari, Tracey, Chai, Siew Yeen
Publicado 2023

Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy

por Walton, Sarah L., Mirabito Colafella, Katrina M., Ansari, Aneesa, Chai, Siew Yeen, Denton, Kate M.
Publicado 2020

Insulin-Regulated Aminopeptidase Inhibition Ameliorates Metabolism in Obese Zucker Rats

por Krskova, Katarina, Balazova, Lucia, Dobrocsyova, Viktoria, Olszanecki, Rafal, Suski, Maciej, Chai, Siew Yeen, Zorad, Štefan
Publicado 2020

Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke

por Telianidis, Jonathon, Hunter, Andrew, Widdop, Robert, Kemp-Harper, Barbara, Pham, Vi, McCarthy, Claudia, Chai, Siew Yeen
Publicado 2023

Age-related reduction in brain ACE-2 is not exacerbated by Alzheimer’s disease pathology in mouse models of Alzheimer’s disease

por MacLachlan, Robert, Evans, Charles E., Chai, Siew Yeen, Good, Mark A., Kehoe, Patrick Gavin, Miners, J. Scott
Publicado 2022

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase

por Chai, Siew Yeen, Yeatman, Holly R, Parker, Michael W, Ascher, David B, Thompson, Philip E, Mulvey, Hayley T, Albiston, Anthony L
Publicado 2008

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

por Vanga, Sudarsana Reddy, Sävmarker, Jonas, Ng, Leelee, Larhed, Mats, Hallberg, Mathias, Åqvist, Johan, Hallberg, Anders, Chai, Siew Yeen, Gutiérrez-de-Terán, Hugo
Publicado 2018

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

por Grubman, Alexandra, Choo, Xin Yi, Chew, Gabriel, Ouyang, John F., Sun, Guizhi, Croft, Nathan P., Rossello, Fernando J., Simmons, Rebecca, Buckberry, Sam, Landin, Dulce Vargas, Pflueger, Jahnvi, Vandekolk, Teresa H., Abay, Zehra, Zhou, Yichen, Liu, Xiaodong, Chen, Joseph, Larcombe, Michael, Haynes, John M., McLean, Catriona, Williams, Sarah, Chai, Siew Yeen, Wilson, Trevor, Lister, Ryan, Pouton, Colin W., Purcell, Anthony W., Rackham, Owen J. L., Petretto, Enrico, Polo, Jose M.
Publicado 2021