Decoding the Conformational Selective Mechanism of FGFR Isoforms: A Comparative Molecular Dynamics Simulation

por Zhang, Mingyang, Yasen, Miersalijiang, Lu, Shaoyong, Ma, De-Ning, Chai, Zongtao
Publicado 2023

Understanding the P-Loop Conformation in the Determination of Inhibitor Selectivity Toward the Hepatocellular Carcinoma-Associated Dark Kinase STK17B

por Liu, Chang, Li, Zhizhen, Liu, Zonghan, Yang, Shiye, Wang, Qing, Chai, Zongtao
Publicado 2022

Mechanistic Insights into the Mechanism of Inhibitor Selectivity toward the Dark Kinase STK17B against Its High Homology STK17A

por Liu, Chang, Zhang, Yichi, Zhang, Yuqing, Liu, Zonghan, Mao, Feifei, Chai, Zongtao
Publicado 2022

All-trans-retinoic acid (ATRA) plus oxaliplatin plus 5-fluorouracil/leucovorin (FOLFOX) versus FOLFOX alone as palliative chemotherapy in patients with advanced hepatocellular carc...

por Shi, Jie, Sun, Juxian, Liu, Chang, Chai, Zongtao, Wang, Nanya, Zhang, Hui, Cheng, Shuqun
Publicado 2019

MicroRNA-101 modulates cisplatin chemoresistance in liver cancer cells via the DNA-PKcs signaling pathway

por Chai, Zongtao, Yin, Xiaolan, Chen, Jin, Shi, Jie, Sun, Juxian, Liu, Chang, Liu, Feng, Cheng, Shuqun
Publicado 2019

Atomic-scale insights into allosteric inhibition and evolutional rescue mechanism of Streptococcus thermophilus Cas9 by the anti-CRISPR protein AcrIIA6

por Li, Xinyi, Wang, Chengxiang, Peng, Ting, Chai, Zongtao, Ni, Duan, Liu, Yaqin, Zhang, Jian, Chen, Ting, Lu, Shaoyong
Publicado 2021

Mechanistic Insights into the Protection Effect of Argonaute–RNA Complex on the HCV Genome

por Zhuang, Haiming, Ji, Dong, Fan, Jigang, Li, Mingyu, Tao, Ran, Du, Kui, Lu, Shaoyong, Chai, Zongtao, Fan, Xiaohua
Publicado 2022

Elucidation of the conformational dynamics and assembly of Argonaute–RNA complexes by distinct yet coordinated actions of the supplementary microRNA

por Zhuang, Haiming, Fan, Xiaohua, Ji, Dong, Wang, Yuanhao, Fan, Jigang, Li, Mingyu, Ni, Duan, Lu, Shaoyong, Li, Xiaolong, Chai, Zongtao
Publicado 2022

Insights into the Allosteric Effect of SENP1 Q597A Mutation on the Hydrolytic Reaction of SUMO1 via an Integrated Computational Study

por Ji, Mingfei, Chai, Zongtao, Chen, Jie, Li, Gang, Li, Qiang, Li, Miao, Ding, Yelei, Lu, Shaoyong, Ju, Guanqun, Hou, Jianquan
Publicado 2022

Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators

por Qiu, Yuran, Wang, Yuanhao, Chai, Zongtao, Ni, Duan, Li, Xinyi, Pu, Jun, Chen, Jie, Zhang, Jian, Lu, Shaoyong, Lv, Chuan, Ji, Mingfei
Publicado 2021

Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design

por Lu, Shaoyong, He, Xinheng, Yang, Zhao, Chai, Zongtao, Zhou, Shuhua, Wang, Junyan, Rehman, Ashfaq Ur, Ni, Duan, Pu, Jun, Sun, Jinpeng, Zhang, Jian
Publicado 2021

Nujiangexanthone A Inhibits Hepatocellular Carcinoma Metastasis via Down Regulation of Cofilin 1

por Zhang, Li, Chai, Zongtao, Kong, Siyuan, Feng, Jiling, Wu, Man, Tan, Jiaqi, Yuan, Man, Chen, Gan, Li, Zhuo, Zhou, Hua, Cheng, Shuqun, Xu, Hongxi
Publicado 2021

Insufficient Radiofrequency Ablation Treated Hepatocellular Carcinoma Cells Promote Metastasis by Up-Regulation ITGB3

por Zhang, Ning, Ma, Dening, Wang, Lu, Zhu, Xiaodong, Pan, Qi, Zhao, Yiming, Zhu, Weiping, Zhou, Jiamin, Wang, Longrong, Chai, Zongtao, Ao, Jianyang, Sun, Huichuan, Tang, Zhaoyou
Publicado 2017