Promiscuous Expression of H2B-GFP Transgene in Hematopoietic Stem Cells

por Challen, Grant A., Goodell, Margaret A.
Publicado 2008

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

por Young, Andrew L., Challen, Grant A., Birmann, Brenda M., Druley, Todd E.
Publicado 2016

Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma

por Rauch, Daniel A., Olson, Sydney L., Harding, John C., Sundaramoorthi, Hemalatha, Kim, Youngsoo, Zhou, Tianyuan, MacLeod, A. Robert, Challen, Grant, Ratner, Lee
Publicado 2020

Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness

por Ostrander, Elizabeth L., Kramer, Ashley C., Mallaney, Cates, Celik, Hamza, Koh, Won Kyun, Fairchild, Jake, Haussler, Emily, Zhang, Christine R.C., Challen, Grant A.
Publicado 2020

Radiation induces iatrogenic immunosuppression by indirectly affecting hematopoiesis in bone marrow

por Kapoor, Vaishali, Collins, Andrea, Griffith, Kaylan, Ghosh, Subhajit, Wong, Nathan, Wang, Xiaowei, Challen, Grant A., Krambs, Joseph, Link, Dan, Hallahan, Dennis E., Thotala, Dinesh
Publicado 2020

Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation

por McDonald, James I., Celik, Hamza, Rois, Lisa E., Fishberger, Gregory, Fowler, Tolison, Rees, Ryan, Kramer, Ashley, Martens, Andrew, Edwards, John R., Challen, Grant A.
Publicado 2016

Kdm6b Regulates Context-Dependent Hematopoietic Stem Cell Self-Renewal and Leukemogenesis

por Mallaney, Cates, Ostrander, Elizabeth L., Celik, Hamza, Kramer, Ashley C., Martens, Andrew, Kothari, Alok, Kyun Koh, Won, Haussler, Emily, Iwamori, Naoki, Gontarz, Paul, Zhang, Bo, Challen, Grant A.
Publicado 2019

Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis

por SanMiguel, Jennifer M., Eudy, Elizabeth, Loberg, Matthew A., Young, Kira A., Mistry, Jayna J., Mujica, Kristina D., Schwartz, Logan S., Stearns, Timothy M., Challen, Grant A., Trowbridge, Jennifer J.
Publicado 2022

Pevonedistat targets malignant cells in myeloproliferative neoplasms in vitro and in vivo via NFκB pathway inhibition

por Kong, Tim, Laranjeira, Angelo B.A., Collins, Taylor B., De Togni, Elisa S., Wong, Abigail J., Fulbright, Mary C., Ruzinova, Marianna, Celik, Hamza, Challen, Grant A., Fisher, Daniel A.C., Oh, Stephen T.
Publicado 2022

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo

por Jeong, Mira, Park, Hyun Jung, Celik, Hamza, Ostrander, Elizabeth L., Reyes, Jaime M., Guzman, Anna, Rodriguez, Benjamin, Lei, Yong, Lee, Yeojin, Ding, Lei, Guryanova, Olga A., Li, Wei, Goodell, Margaret A., Challen, Grant A.
Publicado 2018

Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF

por Cheng, Xiaogang, Joseph, Ancy, Castro, Victor, Chen-Liaw, Alice, Skidmore, Zachary, Ueno, Takaharu, Fujisawa, Jun-ichi, Rauch, Daniel A., Challen, Grant A., Martinez, Michael P., Green, Patrick, Griffith, Malachi, Payton, Jacqueline E., Edwards, John R., Ratner, Lee
Publicado 2021

Dnmt3a Regulates T-cell Development and Suppresses T-ALL Transformation

por Kramer, Ashley C., Kothari, Alok, Wilson, W. Casey, Celik, Hamza, Nikitas, John, Mallaney, Cates, Ostrander, Elizabeth L., Eultgen, Elizabeth, Martens, Andrew, Valentine, Mark C., Young, Andrew L., Druley, Todd E., Figueroa, Maria E., Zhang, Bo, Challen, Grant A.
Publicado 2017

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance

por Meyer, Melissa A., Baer, John M., Knolhoff, Brett L., Nywening, Timothy M., Panni, Roheena Z., Su, Xinming, Weilbaecher, Katherine N., Hawkins, William G., Ma, Cynthia, Fields, Ryan C., Linehan, David C., Challen, Grant A., Faccio, Roberta, Aft, Rebecca L., DeNardo, David G.
Publicado 2018

Large conserved domains of low DNA methylation maintained by Dnmt3a

por Jeong, Mira, Sun, Deqiang, Luo, Min, Huang, Yun, Challen, Grant A., Rodriguez, Benjamin, Zhang, Xiaotian, Chavez, Lukas, Wang, Hui, Hannah, Rebecca, Kim, Sang-Bae, Yang, Liubin, Ko, Myunggon, Chen, Rui, Göttgens, Berthold, Lee, Ju-Seog, Gunaratne, Preethi, Godley, Lucy A., Darlington, Gretchen J., Rao, Anjana, Li, Wei, Goodell, Margaret A.
Publicado 2013