"Arming" the chimeric oncolytic adenovirus enadenotucirev to deliver checkpoint inhibitors and other therapeutics directly to tumours

por Champion, Brian R, Kodialbail, Prithvi, Illingworth, Sam, Rasiah, Nalini, Cochrane, Dan, Beadle, John, Fisher, Kerry, Brown, Alice CN
Publicado 2014

Arming the oncolytic virus enadenotucirev (EnAd) to generate enhanced locally-acting immunotherapies for cancer

por Champion, Brian R, Rasiah, Nalini, Illingworth, Sam, Calderon, Hugo, Besneux, Matthieu, Lear, Rochelle, Plumb, Darren, Kodialbail, Prithvi, Brown, Alice
Publicado 2015

Development of a versatile oncolytic virus platform for local intra-tumoural expression of therapeutic transgenes

por Marino, Nalini, Illingworth, Sam, Kodialbail, Prithvi, Patel, Ashvin, Calderon, Hugo, Lear, Rochelle, Fisher, Kerry D., Champion, Brian R., Brown, Alice C. N.
Publicado 2017

T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice

por Sonzogni, Olmo, Zak, Daniel E., Sasso, Maria Stella, Lear, Rochelle, Muntzer, Alice, Zonca, Manuela, West, Katy, Champion, Brian R., Rottman, James B.
Publicado 2022

Immunogenicity of a peptide‐based anti‐IgE conjugate vaccine in non‐human primates

por Weeratna, Risini D., Chikh, Ghania, Zhang, Lu, Fraser, James D., Thorn, Jennifer M., Merson, James R., McCluskie, Michael J., Champion, Brian R., Davis, Heather L.
Publicado 2016

Bi- and tri-valent T cell engagers deplete tumour-associated macrophages in cancer patient samples

por Scott, Eleanor M., Jacobus, Egon J., Lyons, Brian, Frost, Sally, Freedman, Joshua D., Dyer, Arthur, Khalique, Hena, Taverner, William K., Carr, Alison, Champion, Brian R., Fisher, Kerry D., Seymour, Len W., Duffy, Margaret R.
Publicado 2019

External Beam Radiation Therapy and Enadenotucirev: Inhibition of the DDR and Mechanisms of Radiation-Mediated Virus Increase

por Pokrovska, Tzveta D., Jacobus, Egon J., Puliyadi, Rathi, Prevo, Remko, Frost, Sally, Dyer, Arthur, Baugh, Richard, Rodriguez-Berriguete, Gonzalo, Fisher, Kerry, Granata, Giovanna, Herbert, Katharine, Taverner, William K., Champion, Brian R., Higgins, Geoff S., Seymour, Len W., Lei-Rossmann, Janet
Publicado 2020