RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis

por Chan, Ho Yin Edwin
Publicado 2014

Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases

por Koon, Alex C., Chan, Ho Yin Edwin
Publicado 2017

Transcriptional dysregulation in neurodegenerative diseases: who tipped the balance of Yin Yang 1 in the brain?

por Chen, Zhefan Stephen, Chan, Ho Yin Edwin
Publicado 2019

Multifaceted investigation underlies diverse mechanisms contributing to the downregulation of Hedgehog pathway-associated genes INTU and IFT88 in lung adenocarcinoma and uterine co...

por Chan, Ho Yin Edwin, Chen, Zhefan Stephen
Publicado 2022

A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3

por Chen, Zhefan Stephen, Huang, Xiaoying, Talbot, Kevin, Chan, Ho Yin Edwin
Publicado 2021

Molecular insights into the interaction of CAG trinucleotide RNA repeats with nucleolin and its implication in polyglutamine diseases

por An, Ying, Chen, Zhefan S, Chan, Ho Yin Edwin, Ngo, Jacky Chi Ki
Publicado 2022

Pan-cancer investigation reveals mechanistic insights of planar cell polarity gene Fuz in carcinogenesis

por Chen, Zhefan Stephen, Lin, Xiao, Chan, Ting-Fung, Chan, Ho Yin Edwin
Publicado 2021

Co-Encapsulation and Co-Delivery of Peptide Drugs via Polymeric Nanoparticles

por Kim, Ma Rie, Feng, Teng, Zhang, Qian, Chan, Ho Yin Edwin, Chau, Ying
Publicado 2019

The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway

por Chan, Chak-Ming, Ma, Cheuk-Wing, Chan, Wood-Yee, Chan, Ho Yin Edwin
Publicado 2007

Isolation and Identification of a Novel Anti-protein Aggregation Activity of Lignin-Carbohydrate Complex From Chionanthus retusus Leaves

por Pei, Wenhui, Chen, Zhefan Stephen, Chan, Ho Yin Edwin, Zheng, Liming, Liang, Chen, Huang, Caoxing
Publicado 2020

Development of Fluorescent Turn-On Probes for CAG-RNA Repeats

por Lau, Matthew Ho Yan, Wong, Chun-Ho, Chan, Ho Yin Edwin, Au-Yeung, Ho Yu
Publicado 2022

Whole-genome sequencing of two probands with hereditary spastic paraplegia reveals novel splice-donor region variant and known pathogenic variant in SPG11

por Yu, Allen Chi-Shing, Chan, Anne Yin-Yan, Au, Wing Chi, Shen, Yun, Chan, Ting Fung, Chan, Ho-Yin Edwin
Publicado 2016

A Peptidylic Inhibitor for Neutralizing (r)(GGGGCC)(exp)-Associated Neurodegeneration in C9ALS-FTD

por Zhang, Qian, An, Ying, Chen, Zhefan Stephen, Koon, Alex Chun, Lau, Kwok-Fai, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin
Publicado 2019

A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities

por Peng, Shaohong Isaac, Leong, Lok I., Sun, Jacquelyne Ka-Li, Chen, Zhefan Stephen, Chow, Hei-Man, Chan, Ho Yin Edwin
Publicado 2022

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

por Zhang, Qian, Tsoi, Ho, Peng, Shaohong, Li, Pan P., Lau, Kwok-Fai, Rudnicki, Dobrila D., Ngo, Jacky Chi-Ki, Chan, Ho Yin Edwin
Publicado 2016

The ion channel activity of the SARS-coronavirus 3a protein is linked to its pro-apoptotic function

por Chan, Chak-Ming, Tsoi, Ho, Chan, Wing-Man, Zhai, Shenyu, Wong, Ching-On, Yao, Xiaoqiang, Chan, Wood-Yee, Tsui, Stephen Kwok-Wing, Chan, Ho Yin Edwin
Publicado 2009

The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity

por Ng, Chun-Fai, Ko, Chun-Hay, Koon, Chi-Man, Xian, Jia-Wen, Leung, Ping-Chung, Fung, Kwok-Pui, Chan, Ho Yin Edwin, Lau, Clara Bik-San
Publicado 2013

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

por Zhang, Qian, Chen, Zhefan Stephen, An, Ying, Liu, Haizhen, Hou, Yonghui, Li, Wen, Lau, Kwok-Fai, Koon, Alex Chun, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin
Publicado 2018

Nuclear retention of full-length HTT RNA is mediated by splicing factors MBNL1 and U2AF65

por Sun, Xin, Li, Pan P., Zhu, Shanshan, Cohen, Rachael, Marque, Leonard O., Ross, Christopher A., Pulst, Stefan M., Chan, Ho Yin Edwin, Margolis, Russell L., Rudnicki, Dobrila D.
Publicado 2015

Phosphorylation of FE65 Ser(610) by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing

por Chow, Wan Ning Vanessa, Ngo, Jacky Chi Ki, Li, Wen, Chen, Yu Wai, Tam, Ka Ming Vincent, Chan, Ho Yin Edwin, Miller, Christopher C.J., Lau, Kwok-Fai
Publicado 2015