Chemoattractants Induce a Rapid and Transient Upregulation of Monocyte α4 Integrin Affinity for Vascular Cell Adhesion Molecule 1 Which Mediates Arrest: An Early Step in the Proces...

por Chan, Jason R., Hyduk, Sharon J., Cybulsky, Myron I.
Publicado 2001

Incorporating Placebo Response in Quantitative Systems Pharmacology Models

por Wang, Evan B., Shen, Lei, Heathman, Michael, Chan, Jason R.
Publicado 2019

Alternate virtual populations elucidate the type I interferon signature predictive of the response to rituximab in rheumatoid arthritis

por Schmidt, Brian J, Casey, Fergal P, Paterson, Thomas, Chan, Jason R
Publicado 2013

A Flexible Approach for Context‐Dependent Assessment of Quantitative Systems Pharmacology Models

por Ramanujan, Saroja, Chan, Jason R., Friedrich, Christina M., Thalhauser, Craig J.
Publicado 2019

Virtual Optimization of Nasal Insulin Therapy Predicts Immunization Frequency to Be Crucial for Diabetes Protection

por Fousteri, Georgia, Chan, Jason R., Zheng, Yanan, Whiting, Chan, Dave, Amy, Bresson, Damien, Croft, Michael, von Herrath, Matthias
Publicado 2010

Preexisting Autoantibodies Predict Efficacy of Oral Insulin to Cure Autoimmune Diabetes in Combination With Anti-CD3

por Mamchak, Alusha A., Manenkova, Yulia, Leconet, Wilhem, Zheng, Yanan, Chan, Jason R., Stokes, Cynthia L., Shoda, Lisl K.M., von Herrath, Matthias, Bresson, Damien
Publicado 2012

Target modulation and pharmacokinetics/pharmacodynamics translation of the BTK inhibitor poseltinib for model-informed phase II dose selection

por Byun, Joo-Yun, Koh, Yi T., Jang, Sun Young, Witcher, Jennifer W., Chan, Jason R., Pustilnik, Anna, Daniels, Mark J., Kim, Young Hoon, Suh, Kwee Hyun, Linnik, Matthew D., Lee, Young-Mi
Publicado 2021

Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities

por Bradshaw, Erica L., Spilker, Mary E., Zang, Richard, Bansal, Loveleena, He, Handan, Jones, Rhys D.O., Le, Kha, Penney, Mark, Schuck, Edgar, Topp, Brian, Tsai, Alice, Xu, Christine, Nijsen, Marjoleen J.M.A., Chan, Jason R.
Publicado 2019

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

por Chan, Jason R., Blumenschein, Wendy, Murphy, Erin, Diveu, Caroline, Wiekowski, Maria, Abbondanzo, Susan, Lucian, Linda, Geissler, Richard, Brodie, Scott, Kimball, Alexa B., Gorman, Daniel M., Smith, Kathleen, de Waal Malefyt, Rene, Kastelein, Robert A., McClanahan, Terrill K., Bowman, Edward P.
Publicado 2006

Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape

por Nijsen, Marjoleen J.M.A., Wu, Fan, Bansal, Loveleena, Bradshaw‐Pierce, Erica, Chan, Jason R., Liederer, Bianca M., Mettetal, Jerome T., Schroeder, Patricia, Schuck, Edgar, Tsai, Alice, Xu, Christine, Chimalakonda, Anjaneya, Le, Kha, Penney, Mark, Topp, Brian, Yamada, Akihiro, Spilker, Mary E.
Publicado 2018

Current practices for QSP model assessment: an IQ consortium survey

por Chan, Jason R., Allen, Richard, Boras, Britton, Cabal, Antonio, Damian, Valeriu, Gibbons, Francis D., Gulati, Abhishek, Hosseini, Iraj, Kearns, Jeffrey D., Saito, Ryuta, Cucurull-Sanchez, Lourdes, Selimkhanov, Jangir, Stein, Andrew M., Umehara, Kenichi, Wang, Guanyu, Wang, Weirong, Neves-Zaph, Susana
Publicado 2022