FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

por Chan, Keefe T., Cortesio, Christa L., Huttenlocher, Anna
Publicado 2009

Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin

por Chan, Keefe T., Roadcap, David W., Holoweckyj, Nicholas, Bear, James E.
Publicado 2012

Cystathionine β-Synthase in Physiology and Cancer

por Zhu, Haoran, Blake, Shaun, Chan, Keefe T., Pearson, Richard B., Kang, Jian
Publicado 2018

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy

por Kang, Jian, Brajanovski, Natalie, Chan, Keefe T., Xuan, Jiachen, Pearson, Richard B., Sanij, Elaine
Publicado 2021

Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion

por Cortesio, Christa L., Chan, Keefe T., Perrin, Benjamin J., Burton, Nicholas O., Zhang, Sheng, Zhang, Zhong-Yin, Huttenlocher, Anna
Publicado 2008

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

por Yan, Shunfei, Frank, Daniel, Son, Jinbae, Hannan, Katherine M., Hannan, Ross D., Chan, Keefe T., Pearson, Richard B., Sanij, Elaine
Publicado 2017

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues

por Chan, Keefe T., Asokan, Sreeja B., King, Samantha J., Bo, Tao, Dubose, Evan S., Liu, Wenjin, Berginski, Matthew E., Simon, Jeremy M., Davis, Ian J., Gomez, Shawn M., Sharpless, Norman E., Bear, James E.
Publicado 2014

Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

por Zhu, Haoran, Chan, Keefe T, Huang, Xinran, Cerra, Carmelo, Blake, Shaun, Trigos, Anna S, Anderson, Dovile, Creek, Darren J, De Souza, David P, Wang, Xi, Fu, Caiyun, Jana, Metta, Sanij, Elaine, Pearson, Richard B, Kang, Jian
Publicado 2022

A functional genetic screen defines the AKT-induced senescence signaling network

por Chan, Keefe T., Blake, Shaun, Zhu, Haoran, Kang, Jian, Trigos, Anna S., Madhamshettiwar, Piyush B., Diesch, Jeannine, Paavolainen, Lassi, Horvath, Peter, Hannan, Ross D., George, Amee J., Sanij, Elaine, Hannan, Katherine M., Simpson, Kaylene J., Pearson, Richard B.
Publicado 2019

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

por Creed, Sarah J., Le, Caroline P., Hassan, Mona, Pon, Cindy K., Albold, Sabine, Chan, Keefe T., Berginski, Matthew E., Huang, Zhendong, Bear, James E., Lane, J. Robert, Halls, Michelle L., Ferrari, Davide, Nowell, Cameron J., Sloan, Erica K.
Publicado 2015

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-gra...

por Yan, Shunfei, Xuan, Jiachen, Brajanovski, Natalie, Tancock, Madeleine R. C., Madhamshettiwar, Piyush B., Simpson, Kaylene J., Ellis, Sarah, Kang, Jian, Cullinane, Carleen, Sheppard, Karen E., Hannan, Katherine M., Hannan, Ross D., Sanij, Elaine, Pearson, Richard B., Chan, Keefe T.
Publicado 2020

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

por Kusnadi, Eric P, Trigos, Anna S, Cullinane, Carleen, Goode, David L, Larsson, Ola, Devlin, Jennifer R, Chan, Keefe T, De Souza, David P, McConville, Malcolm J, McArthur, Grant A, Thomas, George, Sanij, Elaine, Poortinga, Gretchen, Hannan, Ross D, Hannan, Katherine M, Kang, Jian, Pearson, Richard B
Publicado 2020

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

por Quin, Jaclyn, Chan, Keefe T., Devlin, Jennifer R., Cameron, Donald P., Diesch, Jeannine, Cullinane, Carleen, Ahern, Jessica, Khot, Amit, Hein, Nadine, George, Amee J., Hannan, Katherine M, Poortinga, Gretchen, Sheppard, Karen E., Khanna, Kum Kum, Johnstone, Ricky W., Drygin, Denis, McArthur, Grant A., Pearson, Richard B., Sanij, Elaine, Hannan, Ross D.
Publicado 2016

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

por Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E., Pearson, Richard B.
Publicado 2020

Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

por AbuHammad, Shatha, Cullinane, Carleen, Martin, Claire, Bacolas, Zoe, Ward, Teresa, Chen, Huiqin, Slater, Alison, Ardley, Kerry, Kirby, Laura, Chan, Keefe T., Brajanovski, Natalie, Smith, Lorey K., Rao, Aparna D., Lelliott, Emily J., Kleinschmidt, Margarete, Vergara, Ismael A., Papenfuss, Anthony T., Lau, Peter, Ghosh, Prerana, Haupt, Sue, Haupt, Ygal, Sanij, Elaine, Poortinga, Gretchen, Pearson, Richard B., Falk, Hendrik, Curtis, David J., Stupple, Paul, Devlin, Mark, Street, Ian, Davies, Michael A., McArthur, Grant A., Sheppard, Karen E.
Publicado 2019