One cannot rule them all: Are bacterial toxins-antitoxins druggable?

por Chan, Wai Ting, Balsa, Dolors, Espinosa, Manuel
Publicado 2015

Keeping the Wolves at Bay: Antitoxins of Prokaryotic Type II Toxin-Antitoxin Systems

por Chan, Wai Ting, Espinosa, Manuel, Yeo, Chew Chieng
Publicado 2016

Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon

por Chan, Wai Ting, Yeo, Chew Chieng, Sadowy, Ewa, Espinosa, Manuel
Publicado 2014

Interactions of the Streptococcus pneumoniae Toxin-Antitoxin RelBE Proteins with Their Target DNA

por Moreno-Córdoba, Inmaculada, Chan, Wai-Ting, Nieto, Concha, Espinosa, Manuel
Publicado 2021

Type II bacterial toxin–antitoxins: hypotheses, facts, and the newfound plethora of the PezAT system

por Chan, Wai Ting, Garcillán-Barcia, Maria Pilar, Yeo, Chew Chieng, Espinosa, Manuel
Publicado 2023

Safety and pharmacological characterization of the molecular tweezer CLR01 – a broad-spectrum inhibitor of amyloid proteins’ toxicity

por Attar, Aida, Chan, Wai-Ting Coco, Klärner, Frank-Gerrit, Schrader, Thomas, Bitan, Gal
Publicado 2014

Heterologous Expression of Toxins from Bacterial Toxin-Antitoxin Systems in Eukaryotic Cells: Strategies and Applications

por Yeo, Chew Chieng, Abu Bakar, Fauziah, Chan, Wai Ting, Espinosa, Manuel, Harikrishna, Jennifer Ann
Publicado 2016

A Shortened Barnes Maze Protocol Reveals Memory Deficits at 4-Months of Age in the Triple-Transgenic Mouse Model of Alzheimer's Disease

por Attar, Aida, Liu, Tingyu, Chan, Wai-Ting Coco, Hayes, Jane, Nejad, Mona, Lei, KaiChyuan, Bitan, Gal
Publicado 2013

The Streptococcus pneumoniae yefM-yoeB and relBE Toxin-Antitoxin Operons Participate in Oxidative Stress and Biofilm Formation

por Chan, Wai Ting, Domenech, Mirian, Moreno-Córdoba, Inmaculada, Navarro-Martínez, Verónica, Nieto, Concha, Moscoso, Miriam, García, Ernesto, Espinosa, Manuel
Publicado 2018

Streptococcus pneumoniae Induces Autophagy through the Inhibition of the PI3K-I/Akt/mTOR Pathway and ROS Hypergeneration in A549 Cells

por Li, Pu, Shi, Jing, He, Qiao, Hu, Qin, Wang, Yun Ying, Zhang, Li Jun, Chan, Wai Ting, Chen, Wei-Xian
Publicado 2015