A novel recombinant immunotoxin-based therapy targeting wild-type and mutant EGFR improves survival in murine models of glioblastoma

por Chandramohan, Vidyalakshmi, Bigner, Darell D
Publicado 2013

EGFR/EGFRvIII-targeted immunotoxin therapy for the treatment of glioblastomas via convection-enhanced delivery

por Bao, Xuhui, Pastan, Ira, Bigner, Darell D., Chandramohan, Vidyalakshmi
Publicado 2016

Toxin-Based Targeted Therapy for Malignant Brain Tumors

por Chandramohan, Vidyalakshmi, Sampson, John H., Pastan, Ira, Bigner, Darell D.
Publicado 2012

SYST-12 D2C7 CAR: A NOVEL CAR T CELL THAT SIMULTANEOUSLY TARGETS WILDTYPE EGFR AND ITS MUTANT ISOFORM EGFRVIII FOR TREATMENT OF GLIOMA AND BRAIN METASTASES

por Wilkinson, Daniel, Ryan, Katherine, Wilson, Joseph, Chandramohan, Vidyalakshmi, Bigner, Darell, Fecci, Peter
Publicado 2022

SYST-14 D2C7 CAR EFFECTIVELY AND SAFELY TREATS EGFRWT AND EGFRVIII-EXPRESSING TUMORS FOLLOWING INTRACRANIAL ADMINISTRATION

por Wilkinson, Daniel, Wilson, Joseph, Lerner, Emily, Ryan, Katherine, Chandramohan, Vidyalakshmi, Landi, Daniel, Bigner, Darell, Fecci, Peter
Publicado 2023

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors

por Yu, Xin, Dobrikov, Mikhail, Keir, Stephen T., Gromeier, Matthias, Pastan, Ira H., Reisfeld, Ralph, Bigner, Darell D., Chandramohan, Vidyalakshmi
Publicado 2019

IMMU-27. ANALYSIS OF IMMUNE SIGNATURES IN PEDIATRIC GLIOBLASTOMAS FOR PATIENT STRATIFICATION TO IMMUNOTHERAPY

por Chandramohan, Vidyalakshmi, Evangelous, Tyler, Lipp, Eric S, Hora, Bhavna, Bigner, Darell D, McLendon, Roger E, Ashley, David M
Publicado 2020

LGG-13. GANGLIOGLIOMA DEEP TRANSCRIPTOMICS REVEALS A CD34+ PRIMITIVE NEUROECTODERM NEURAL PRECURSOR-LIKE POPULATION

por Regal, Joshua, Guerra-Garcia, Maria, Jain, Vaibhav, Chandramohan, Vidyalakshmi, Ashley, David, Gregory, Simon, Thompson, Eric, Lopez, Giselle, Reitman, Zachary
Publicado 2023

Antitumor efficacy of D2C7-(scdsFv)-PE38KDEL, a novel immunotoxin targeting EGFRwt and EGFRvIII, by convection-enhanced delivery in orthotopic brain tumor mouse models

por Bao, Xuhui, Chandramohan, Vidyalakshmi, Keir, Stephen T, Pegram, Charles N, McLendon, Roger E, Kuan, Chien-Tsun, Pastan, Ira H, Bigner, Darell D
Publicado 2013

Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population

por Regal, Joshua A., Guerra García, María E., Jain, Vaibhav, Chandramohan, Vidyalakshmi, Ashley, David M., Gregory, Simon G., Thompson, Eric M., López, Giselle Y., Reitman, Zachary J.
Publicado 2023

Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models

por Keir, Stephen T., Chandramohan, Vidyalakshmi, Hemphill, Carlee D., Grandal, Michael M., Melander, Maria Carlsen, Pedersen, Mikkel W., Horak, Ivan D., Kragh, Michael, Desjardins, Annick, Friedman, Henry S., Bigner, Darell D.
Publicado 2018

Targeted inhibition of protein synthesis renders cancer cells vulnerable to apoptosis by unfolded protein response

por Gsottberger, Franziska, Meier, Christina, Ammon, Anna, Parker, Scott, Wendland, Kerstin, George, Rebekka, Petkovic, Srdjan, Mellenthin, Lisa, Emmerich, Charlotte, Lutzny-Geier, Gloria, Metzler, Markus, Mackensen, Andreas, Chandramohan, Vidyalakshmi, Müller, Fabian
Publicado 2023

Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations

por Chandramohan, Vidyalakshmi, Bao, Xuhui, Yu, Xin, Parker, Scott, McDowall, Charlotte, Yu, Yen-Rei, Healy, Patrick, Desjardins, Annick, Gunn, Michael D., Gromeier, Matthias, Nair, Smita K., Pastan, Ira H., Bigner, Darell D.
Publicado 2019

Th17 Immunity in the Colon Is Controlled by Two Novel Subsets of Colon-Specific Mononuclear Phagocytes

por Huang, Hsin-I., Jewell, Mark L., Youssef, Nourhan, Huang, Min-Nung, Hauser, Elizabeth R., Fee, Brian E., Rudemiller, Nathan P., Privratsky, Jamie R., Zhang, Junyi J., Reyes, Estefany Y., Wang, Donghai, Taylor, Gregory A., Gunn, Michael D., Ko, Dennis C., Cook, Donald N., Chandramohan, Vidyalakshmi, Crowley, Steven D., Hammer, Gianna Elena
Publicado 2021