Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy

por Johnson, Danielle P., Chandrasekharan, Mahesh B., Dutreix, Marie, Bhaskara, Srividya
Publicado 2021

Structure–function analysis of histone H2B and PCNA ubiquitination dynamics using deubiquitinase-deficient strains

por Radmall, Kaitlin S., Shukla, Prakash K., Leng, Andrew M., Chandrasekharan, Mahesh B.
Publicado 2023

Quantitative Assessment of Histone H2B Monoubiquitination in Yeast Using Immunoblotting

por Leng, Andrew M., Radmall, Kaitlin S., Shukla, Prakash K., Chandrasekharan, Mahesh B.
Publicado 2022

Unification and extensive diversification of M/Orf3-related ion channel proteins in coronaviruses and other nidoviruses

por Tan, Yongjun, Schneider, Theresa, Shukla, Prakash K, Chandrasekharan, Mahesh B, Aravind, L, Zhang, Dapeng
Publicado 2021

The neural stem-cell marker CD24 is specifically upregulated in IDH-mutant glioma

por Tiburcio, Patricia D.B., Locke, Mary C., Bhaskara, Srividya, Chandrasekharan, Mahesh B., Huang, L. Eric
Publicado 2020

Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression

por Bhaskara, Srividya, Jacques, Vincent, Rusche, James R, Olson, Eric N, Cairns, Bradley R, Chandrasekharan, Mahesh B
Publicado 2013

Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription

por Ramakrishnan, Saravanan, Pokhrel, Srijana, Palani, Sowmiya, Pflueger, Christian, Parnell, Timothy J., Cairns, Bradley R., Bhaskara, Srividya, Chandrasekharan, Mahesh B.
Publicado 2016

A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription

por Sdano, Matthew A, Fulcher, James M, Palani, Sowmiya, Chandrasekharan, Mahesh B, Parnell, Timothy J, Whitby, Frank G, Formosa, Tim, Hill, Christopher P
Publicado 2017

Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability

por Shukla, Prakash K., Sinha, Dhiraj, Leng, Andrew M., Bissell, Jesse E., Thatipamula, Shravya, Ganguly, Rajarshi, Radmall, Kaitlin S., Skalicky, Jack J., Shrieve, Dennis C., Chandrasekharan, Mahesh B.
Publicado 2022

Structure and functional determinants of Rad6–Bre1 subunits in the histone H2B ubiquitin-conjugating complex

por Shukla, Prakash K, Bissell, Jesse E, Kumar, Sanjit, Pokhrel, Srijana, Palani, Sowmiya, Radmall, Kaitlin S, Obidi, Onyeka, Parnell, Timothy J, Brasch, Julia, Shrieve, Dennis C, Chandrasekharan, Mahesh B
Publicado 2023

Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1

por Nakanishi, Shima, Lee, Jung Shin, Gardner, Kathryn E., Gardner, Jennifer M., Takahashi, Yoh-hei, Chandrasekharan, Mahesh B., Sun, Zu-Wen, Osley, Mary Ann, Strahl, Brian D., Jaspersen, Sue L., Shilatifard, Ali
Publicado 2009

HDAC1,2 inhibition impairs EZH2- and BBAP- mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma

por Johnson, Danielle P., Spitz, Gabriella S., Tharkar, Shweta, Quayle, Steven N., Shearstone, Jeffrey R., Jones, Simon, McDowell, Maria E., Wellman, Hannah, Tyler, Jessica K., Cairns, Bradley R., Chandrasekharan, Mahesh B., Bhaskara, Srividya
Publicado 2014

A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation

por Hess, Lena, Moos, Verena, Lauber, Arnel A., Reiter, Wolfgang, Schuster, Michael, Hartl, Natascha, Lackner, Daniel, Boenke, Thorina, Koren, Anna, Guzzardo, Paloma M., Gundacker, Brigitte, Riegler, Anna, Vician, Petra, Miccolo, Claudia, Leiter, Susanna, Chandrasekharan, Mahesh B., Vcelkova, Terezia, Tanzer, Andrea, Jun, Jun Qi, Bradner, James, Brosch, Gerald, Hartl, Markus, Bock, Christoph, Bürckstümmer, Tilmann, Kubicek, Stefan, Chiocca, Susanna, Bhaskara, Srividya, Seiser, Christian
Publicado 2022