A simple method to disrupt and restore subunit interaction of acyl-CoA:cholesterol acyltransferase 1

por Neumann, Bryan, Chang, Catherine C.Y., Chang, Ta-Yuan
Publicado 2019

Identification of Soat1 as a Quantitative Trait Locus Gene on Mouse Chromosome 1 Contributing to Hyperlipidemia

por Lu, Zongji, Yuan, Zuobiao, Miyoshi, Toru, Wang, Qian, Su, Zhiguang, Chang, Catherine C., Shi, Weibin
Publicado 2011

Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy

por Duong, Michael Tran, Nasrallah, Ilya M., Wolk, David A., Chang, Catherine C. Y., Chang, Ta-Yuan
Publicado 2021

ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia

por Li, Haibo, Huynh, Thao N., Duong, Michael Tran, Gow, James G., Chang, Catherine C. Y., Chang, Ta Yuan
Publicado 2023

Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity

por Harned, Taylor C., Stan, Radu V., Cao, Ze, Chakrabarti, Rajarshi, Higgs, Henry N., Chang, Catherine C. Y., Chang, Ta Yuan
Publicado 2023

Blocking cholesterol storage to treat Alzheimer’s disease

por Chang, Ta Yuan, Chang, Catherine C. Y., Harned, Taylor C., De La Torre, Adrianna L., Lee, Junghoon, Huynh, Thao N., Gow, James G.
Publicado 2021

Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor

por Guan, Chengcheng, Niu, Yange, Chen, Si-Cong, Kang, Yunlu, Wu, Jing-Xiang, Nishi, Koji, Chang, Catherine C. Y., Chang, Ta-Yuan, Luo, Tuoping, Chen, Lei
Publicado 2020

Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells

por Rogers, Maximillian A., Chang, Catherine C. Y., Maue, Robert A., Melton, Elaina M., Peden, Andrew A., Garver, William S., Lee, Junghoon, Schroen, Peter, Huang, Mitchell, Chang, Ta-Yuan
Publicado 2022

Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Trans...

por De La Torre, Adrianna L., Huynh, Thao N., Chang, Catherine C. Y., Pooler, Darcy B., Ness, Dylan B., Lewis, Lionel D., Pannem, Sanjana, Feng, Yichen, Samkoe, Kimberley S., Hickey, William F., Chang, Ta Yuan
Publicado 2023