TRPML Cation Channels in Inflammation and Immunity

por Spix, Barbara, Chao, Yu-Kai, Abrahamian, Carla, Chen, Cheng-Chang, Grimm, Christian
Publicado 2020

Targeting TPC2 sensitizes acute lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function

por Geisslinger, Franz, Müller, Martin, Chao, Yu-Kai, Grimm, Christian, Vollmar, Angelika M., Bartel, Karin
Publicado 2022

Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect

por Böck, Julia, Krogsaeter, Einar, Passon, Marcel, Chao, Yu-Kai, Sharma, Sapna, Grallert, Harald, Peters, Annette, Grimm, Christian
Publicado 2021

Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice

por Lin, Chen-Ju, Cheng, Yu-Che, Chen, Hung-Chih, Chao, Yu-Kai, Nicholson, Martin W., Yen, Eric C.L., Kamp, Timothy J., Hsieh, Patrick C.H.
Publicado 2022

TRPV4 channels are essential for alveolar epithelial barrier function as protection from lung edema

por Weber, Jonas, Rajan, Suhasini, Schremmer, Christian, Chao, Yu-Kai, Krasteva-Christ, Gabriela, Kannler, Martina, Yildirim, Ali Önder, Brosien, Monika, Schredelseker, Johann, Weissmann, Norbert, Grimm, Christian, Gudermann, Thomas, Dietrich, Alexander
Publicado 2020

Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells

por Siow, Wei Xiong, Kabiri, Yaschar, Tang, Rachel, Chao, Yu-Kai, Plesch, Eva, Eberhagen, Carola, Flenkenthaler, Florian, Fröhlich, Thomas, Bracher, Franz, Grimm, Christian, Biel, Martin, Zischka, Hans, Vollmar, Angelika M., Bartel, Karin
Publicado 2022

Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2

por Netcharoensirisuk, Ponsawan, Abrahamian, Carla, Tang, Rachel, Chen, Cheng-Chang, Rosato, Anna Scotto, Beyers, Wyatt, Chao, Yu-Kai, Filippini, Antonio, Di Pietro, Santiago, Bartel, Karin, Biel, Martin, Vollmar, Angelika M., Umehara, Kaoru, De-Eknamkul, Wanchai, Grimm, Christian
Publicado 2021

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease

por Villella, Valeria R, Venerando, Andrea, Cozza, Giorgio, Esposito, Speranza, Ferrari, Eleonora, Monzani, Romina, Spinella, Mara C, Oikonomou, Vasilis, Renga, Giorgia, Tosco, Antonella, Rossin, Federica, Guido, Stefano, Silano, Marco, Garaci, Enrico, Chao, Yu‐Kai, Grimm, Christian, Luciani, Alessandro, Romani, Luigina, Piacentini, Mauro, Raia, Valeria, Kroemer, Guido, Maiuri, Luigi
Publicado 2018

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

por Gerndt, Susanne, Chen, Cheng-Chang, Chao, Yu-Kai, Yuan, Yu, Burgstaller, Sandra, Scotto Rosato, Anna, Krogsaeter, Einar, Urban, Nicole, Jacob, Katharina, Nguyen, Ong Nam Phuong, Miller, Meghan T, Keller, Marco, Vollmar, Angelika M, Gudermann, Thomas, Zierler, Susanna, Schredelseker, Johann, Schaefer, Michael, Biel, Martin, Malli, Roland, Wahl-Schott, Christian, Bracher, Franz, Patel, Sandip, Grimm, Christian
Publicado 2020

Gut butyrate-producers confer post-infarction cardiac protection

por Chen, Hung-Chih, Liu, Yen-Wen, Chang, Kuan-Cheng, Wu, Yen-Wen, Chen, Yi-Ming, Chao, Yu-Kai, You, Min-Yi, Lundy, David J., Lin, Chen-Ju, Hsieh, Marvin L., Cheng, Yu-Che, Prajnamitra, Ray P., Lin, Po-Ju, Ruan, Shu-Chian, Chen, David Hsin-Kuang, Shih, Edward S. C., Chen, Ke-Wei, Chang, Shih-Sheng, Chang, Cindy M. C., Puntney, Riley, Moy, Amy Wu, Cheng, Yuan-Yuan, Chien, Hsin-Yuan, Lee, Jia-Jung, Wu, Deng-Chyang, Hwang, Ming-Jing, Coonen, Jennifer, Hacker, Timothy A., Yen, C-L. Eric, Rey, Federico E., Kamp, Timothy J., Hsieh, Patrick C. H.
Publicado 2023