Profiling of advanced glycation end products uncovers abiotic stress-specific target proteins in Arabidopsis

por Chaplin, Amanda K, Chernukhin, Igor, Bechtold, Ulrike
Publicado 2019

Genomics, Computational Biology and Drug Discovery for Mycobacterial Infections: Fighting the Emergence of Resistance

por Munir, Asma, Vedithi, Sundeep Chaitanya, Chaplin, Amanda K., Blundell, Tom L.
Publicado 2020

Druggable binding sites in the multicomponent assemblies that characterise DNA double-strand-break repair through non-homologous end joining

por Kefala Stavridi, Antonia, Appleby, Robert, Liang, Shikang, Blundell, Tom L., Chaplin, Amanda K.
Publicado 2020

Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM

por Liang, Shikang, Chaplin, Amanda K., Stavridi, Antonia Kefala, Appleby, Robert, Hnizda, Ales, Blundell, Tom L.
Publicado 2021

Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs

por Liang, Shikang, Thomas, Sherine E., Chaplin, Amanda K., Hardwick, Steven W., Chirgadze, Dimitri Y., Blundell, Tom L.
Publicado 2022

The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces

por Petrus, Marloes L. C., Vijgenboom, Erik, Chaplin, Amanda K., Worrall, Jonathan A. R., van Wezel, Gilles P., Claessen, Dennis
Publicado 2016

Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis

por Munir, Asma, Wilson, Michael T., Hardwick, Steven W., Chirgadze, Dimitri Y., Worrall, Jonathan A.R., Blundell, Tom L., Chaplin, Amanda K.
Publicado 2021

COSMIC Cancer Gene Census 3D database: understanding the impacts of mutations on cancer targets

por Alsulami, Ali F, Torres, Pedro H M, Moghul, Ismail, Arif, Sheikh Mohammed, Chaplin, Amanda K, Vedithi, Sundeep Chaitanya, Blundell, Tom L
Publicado 2021

Photoreduction and validation of haem–ligand intermediate states in protein crystals by in situ single-crystal spectroscopy and diffraction

por Kekilli, Demet, Moreno-Chicano, Tadeo, Chaplin, Amanda K., Horrell, Sam, Dworkowski, Florian S. N., Worrall, Jonathan A. R., Strange, Richard W., Hough, Michael A.
Publicado 2017

SAP domain forms a flexible part of DNA aperture in Ku70/80

por Hnízda, Aleš, Tesina, Petr, Nguyen, Thanh‐Binh, Kukačka, Zdeněk, Kater, Lukas, Chaplin, Amanda K., Beckmann, Roland, Ascher, David B., Novák, Petr, Blundell, Tom L.
Publicado 2021

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

por Chaplin, Amanda K., Hardwick, Steven W., Kefala Stavridi, Antonia, Buehl, Christopher J., Goff, Noah J., Ropars, Virginie, Liang, Shikang, De Oliveira, Taiana Maia, Chirgadze, Dimitri Y., Meek, Katheryn, Charbonnier, Jean-Baptiste, Blundell, Tom L.
Publicado 2021

Surface Passivation with a Perfluoroalkane Brush Improves the Precision of Single-Molecule Measurements

por Bueno-Alejo, Carlos J., Santana Vega, Marina, Chaplin, Amanda K., Farrow, Chloe, Axer, Alexander, Burley, Glenn A., Dominguez, Cyril, Kara, Hesna, Paschalis, Vasileios, Tubasum, Sumera, Eperon, Ian C., Clark, Alasdair W., Hudson, Andrew J.
Publicado 2022

Serial Femtosecond Zero Dose Crystallography Captures a Water‐Free Distal Heme Site in a Dye‐Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in Fe(IV)=O Formatio...

por Lučić, Marina, Svistunenko, Dimitri A., Wilson, Michael T., Chaplin, Amanda K., Davy, Bradley, Ebrahim, Ali, Axford, Danny, Tosha, Takehiko, Sugimoto, Hiroshi, Owada, Shigeki, Dworkowski, Florian S. N., Tews, Ivo, Owen, Robin L., Hough, Michael A., Worrall, Jonathan A. R.
Publicado 2020

PAXX binding to the NHEJ machinery explains functional redundancy with XLF

por Seif-El-Dahan, Murielle, Kefala-Stavridi, Antonia, Frit, Philippe, Hardwick, Steven W., Chirgadze, Dima Y., Maia De Oliviera, Taiana, Britton, Sébastien, Barboule, Nadia, Bossaert, Madeleine, Pandurangan, Arun Prasad, Meek, Katheryn, Blundell, Tom L., Ropars, Virginie, Calsou, Patrick, Charbonnier, Jean-Baptiste, Chaplin, Amanda K.
Publicado 2023

Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins

por Ebrahim, Ali, Moreno-Chicano, Tadeo, Appleby, Martin V., Chaplin, Amanda K., Beale, John H., Sherrell, Darren A., Duyvesteyn, Helen M. E., Owada, Shigeki, Tono, Kensuke, Sugimoto, Hiroshi, Strange, Richard W., Worrall, Jonathan A. R., Axford, Danny, Owen, Robin L., Hough, Michael A.
Publicado 2019

High-throughput structures of protein–ligand complexes at room temperature using serial femtosecond crystallography

por Moreno-Chicano, Tadeo, Ebrahim, Ali, Axford, Danny, Appleby, Martin V., Beale, John H., Chaplin, Amanda K., Duyvesteyn, Helen M. E., Ghiladi, Reza A., Owada, Shigeki, Sherrell, Darren A., Strange, Richard W., Sugimoto, Hiroshi, Tono, Kensuke, Worrall, Jonathan A. R., Owen, Robin L., Hough, Michael A.
Publicado 2019

Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction

por Kefala Stavridi, Antonia, Gontier, Amandine, Morin, Vincent, Frit, Philippe, Ropars, Virginie, Barboule, Nadia, Racca, Carine, Jonchhe, Sagun, Morten, Michael J, Andreani, Jessica, Rak, Alexey, Legrand, Pierre, Bourand-Plantefol, Alexa, Hardwick, Steven W, Chirgadze, Dimitri Y, Davey, Paul, De Oliveira, Taiana Maia, Rothenberg, Eli, Britton, Sebastien, Calsou, Patrick, Blundell, Tom L, Varela, Paloma F, Chaplin, Amanda K, Charbonnier, Jean-Baptiste
Publicado 2023