Enantioselective Aldol Addition of Acetaldehyde to Aromatic Aldehydes Catalyzed by Proline-Based Carboligases

por Saifuddin, Mohammad, Guo, Chao, Biewenga, Lieuwe, Saravanan, Thangavelu, Charnock, Simon J., Poelarends, Gerrit J.
Publicado 2020

Enantioselective Synthesis of α‐Thiocarboxylic Acids by Nitrilase Biocatalysed Dynamic Kinetic Resolution of α‐Thionitriles

por Lauder, Kate, Anselmi, Silvia, Finnigan, James D., Qi, Yuyin, Charnock, Simon J., Castagnolo, Daniele
Publicado 2020

nanoDSF as screening tool for enzyme libraries and biotechnology development

por Magnusson, Anders O., Szekrenyi, Anna, Joosten, Henk‐Jan, Finnigan, James, Charnock, Simon, Fessner, Wolf‐Dieter
Publicado 2018

In Search of Complementary Extraction Methods for Comprehensive Coverage of the Escherichia coli Metabolome

por Gould, Henry, Cheung, William, Finnigan, James D., Muñoz-Muñoz, José, Charnock, Simon J., Black, Gary W.
Publicado 2023

A Coupled Ketoreductase‐Diaphorase Assay for the Detection of Polyethylene Terephthalate‐Hydrolyzing Activity

por Gimeno‐Pérez, María, Finnigan, James D., Echeverria, Coro, Charnock, Simon J., Hidalgo, Aurelio, Mate, Diana M.
Publicado 2022

Asymmetric Synthesis of N‐Substituted α‐Amino Esters from α‐Ketoesters via Imine Reductase‐Catalyzed Reductive Amination

por Yao, Peiyuan, Marshall, James R., Xu, Zefei, Lim, Jesmine, Charnock, Simon J., Zhu, Dunming, Turner, Nicholas J.
Publicado 2021

Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes

por Weise, Nicholas J., Ahmed, Syed T., Parmeggiani, Fabio, Galman, James L., Dunstan, Mark S., Charnock, Simon J., Leys, David, Turner, Nicholas J.
Publicado 2017

Regioselective Radical Alkylation of Arenes Using Evolved Photoenzymes

por Page, Claire G., Cao, Jingzhe, Oblinsky, Daniel G., MacMillan, Samantha N., Dahagam, Shiva, Lloyd, Ruth M., Charnock, Simon J., Scholes, Gregory D., Hyster, Todd K.
Publicado 2023

Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions

por Biewenga, Lieuwe, Saravanan, Thangavelu, Kunzendorf, Andreas, van der Meer, Jan-Ytzen, Pijning, Tjaard, Tepper, Pieter G., van Merkerk, Ronald, Charnock, Simon J., Thunnissen, Andy-Mark W. H., Poelarends, Gerrit J.
Publicado 2019

Rapid Screening of Diverse Biotransformations for Enzyme Evolution

por Kempa, Emily E., Galman, James L., Parmeggiani, Fabio, Marshall, James R., Malassis, Julien, Fontenelle, Clement Q., Vendeville, Jean-Baptiste, Linclau, Bruno, Charnock, Simon J., Flitsch, Sabine L., Turner, Nicholas J., Barran, Perdita E.
Publicado 2021

Synthesis of Stereoenriched Piperidines via Chemo-Enzymatic Dearomatization of Activated Pyridines

por Harawa, Vanessa, Thorpe, Thomas W., Marshall, James R., Sangster, Jack J., Gilio, Amelia K., Pirvu, Lucian, Heath, Rachel S., Angelastro, Antonio, Finnigan, James D., Charnock, Simon J., Nafie, Jordan W., Grogan, Gideon, Whitehead, Roger C., Turner, Nicholas J.
Publicado 2022

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

por Burke, Ashleigh J., Birmingham, William R., Zhuo, Ying, Thorpe, Thomas W., Zucoloto da Costa, Bruna, Crawshaw, Rebecca, Rowles, Ian, Finnigan, James D., Young, Carl, Holgate, Gregory M., Muldowney, Mark P., Charnock, Simon J., Lovelock, Sarah L., Turner, Nicholas J., Green, Anthony P.
Publicado 2022