Spontaneous mouse lymphoma in patient-derived tumor xenografts: The importance of systematic analysis of xenografted human tumor tissues in preclinical efficacy trials

por Chateau-Joubert, Sophie, Hopfe, Miriam, Richon, Sophie, Decaudin, Didier, Roman-Roman, Sergio, Reyes-Gomez, Edouard, Bieche, Ivan, Nemati, Fariba, Dangles-Marie, Virginie
Publicado 2021

PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer

por Spasojevic, Caroline, Marangoni, Elisabetta, Vacher, Sophie, Assayag, Franck, Meseure, Didier, Château-Joubert, Sophie, Humbert, Martine, Karam, Manale, Ricort, Jean Marc, Auclair, Christian, Regairaz, Marie, Bièche, Ivan
Publicado 2018

High‐Mobility Group Box 1–Signaling Inhibition With Glycyrrhizin Prevents Cerebral T‐Cell Infiltration After Cardiac Arrest

por Boissady, Emilie, Abi Zeid Daou, Yara, Faucher, Estelle, Kohlhauer, Matthias, Lidouren, Fanny, El Hedjaj, Cynthia, Chateau‐Joubert, Sophie, Hocini, Hakim, Hue, Sophie, Ghaleh, Bijan, Tissier, Renaud
Publicado 2023

Targeting mTOR pathway inhibits tumor growth in different molecular subtypes of triple-negative breast cancers

por Hatem, Rana, Botty, Rania El, Chateau-Joubert, Sophie, Servely, Jean-Luc, Labiod, Dalila, de Plater, Ludmilla, Assayag, Franck, Coussy, Florence, Callens, Céline, Vacher, Sophie, Reyal, Fabien, Cosulich, Sabina, Diéras, Véronique, Bièche, Ivan, Marangoni, Elisabetta
Publicado 2016

Inhibition of mTOR downregulates expression of DNA repair proteins and is highly efficient against BRCA2-mutated breast cancer in combination to PARP inhibition

por El Botty, Rania, Coussy, Florence, Hatem, Rana, Assayag, Franck, Chateau-Joubert, Sophie, Servely, Jean-Luc, Leboucher, Sophie, Fouillade, Charles, Vacher, Sophie, Ouine, Bérengère, Cartier, Aurélie, de Koning, Leanne, Cottu, Paul, Bièche, Ivan, Marangoni, Elisabetta
Publicado 2018

Combination of mTORC1/2 inhibitor vistusertib plus fulvestrant in vitro and in vivo targets oestrogen receptor-positive endocrine-resistant breast cancer

por Pancholi, Sunil, Leal, Mariana Ferreira, Ribas, Ricardo, Simigdala, Nikiana, Schuster, Eugene, Chateau-Joubert, Sophie, Zabaglo, Lila, Hills, Margaret, Dodson, Andrew, Gao, Qiong, Johnston, Stephen R., Dowsett, Mitch, Cosulich, Sabina C., Maragoni, Elisabetta, Martin, Lesley-Ann
Publicado 2019

Correction to: Combination of mTORC1/2 inhibitor vistusertib plus fulvestrant in vitro and in vivo targets oestrogen receptor-positive endocrine-resistant breast cancer

por Pancholi, Sunil, Leal, Mariana Ferreira, Ribas, Ricardo, Simigdala, Nikiana, Schuster, Eugene, Chateau-Joubert, Sophie, Zabaglo, Lila, Hills, Margaret, Dodson, Andrew, Gao, Qiong, Johnston, Stephen R., Dowsett, Mitch, Cosulich, Sabina C., Marangoni, Elisabetta, Martin, Lesley-Ann
Publicado 2020

HRAS is a therapeutic target in malignant chemo-resistant adenomyoepithelioma of the breast

por Bièche, Ivan, Coussy, Florence, El-Botty, Rania, Vacher, Sophie, Château-Joubert, Sophie, Dahmani, Ahmed, Montaudon, Elodie, Reyes, Cécile, Gentien, David, Reyal, Fabien, Ricci, Francesco, Nicolas, André, Marchio, Caterina, Vincent-Salomon, Anne, Laé, Marick, Marangoni, Elisabetta
Publicado 2021

Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestran...

por Jacquemetton, Julien, Kassem, Loay, Poulard, Coralie, Dahmani, Ahmed, De Plater, Ludmilla, Montaudon, Elodie, Sourd, Laura, Morisset, Ludivine, El Botty, Rania, Chateau-Joubert, Sophie, Vacher, Sophie, Biche, Ivan, Treilleux, Isabelle, Trdan, Olivier, Marangoni, Elisabetta, Le Romancer, Muriel
Publicado 2021

Combination of PI3K and MEK inhibitors yields durable remission in PDX models of PIK3CA-mutated metaplastic breast cancers

por Coussy, F., El Botty, R., Lavigne, M., Gu, C., Fuhrmann, L., Briaux, A., de Koning, L., Dahmani, A., Montaudon, E., Morisset, L., Huguet, L., Sourd, L., Painsec, P., Chateau-Joubert, S., Larcher, T., Vacher, S., Melaabi, S., Salomon, A. Vincent, Marangoni, E., Bieche, I.
Publicado 2020

HORMAD1 overexpression predicts response to anthracycline–cyclophosphamide and survival in triple‐negative breast cancers

por El‐Botty, Rania, Vacher, Sophie, Mainguené, Juliette, Briaux, Adrien, Ibadioune, Sabrina, Dahmani, Ahmed, Montaudon, Elodie, Nemati, Fariba, Huguet, Léa, Sourd, Laura, Morriset, Ludivine, Château‐Joubert, Sophie, Dubois, Thierry, Maire, Virginie, Lidereau, Rosette, Rapinat, Audrey, Gentien, David, Coussy, Florence, Bièche, Ivan, Marangoni, Elisabetta
Publicado 2023

Activation of IFN/STAT1 signalling predicts response to chemotherapy in oestrogen receptor-negative breast cancer

por Legrier, Marie-Emmanuelle, Bièche, Ivan, Gaston, Julie, Beurdeley, Arnaud, Yvonnet, Vanessa, Déas, Olivier, Thuleau, Aurélie, Château-Joubert, Sophie, Servely, Jean-Luc, Vacher, Sophie, Lassalle, Myriam, Depil, Stéphane, C Tucker, Gordon, Fontaine, Jean-Jacques, Poupon, Marie-France, Roman-Roman, Sergio, Judde, Jean-Gabriel, Decaudin, Didier, Cairo, Stefano, Marangoni, Elisabetta
Publicado 2016

Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts

por Coussy, Florence, Lavigne, Marion, de Koning, Leanne, Botty, Rania El, Nemati, Fariba, Naguez, Adnan, Bataillon, Guillaume, Ouine, Berengère, Dahmani, Ahmed, Montaudon, Elodie, Painsec, Pierre, Chateau-Joubert, Sophie, Laetitia, Fuhrmann, Larcher, Thibaut, Vacher, Sophie, Chemlali, Walid, Briaux, Adrien, Melaabi, Samia, Salomon, Anne Vincent, Guinebretiere, Jean Marc, Bieche, Ivan, Marangoni, Elisabetta
Publicado 2020

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC

por Montaudon, Elodie, El Botty, Rania, Vacher, Sophie, Déas, Olivier, Naguez, Adnan, Chateau-Joubert, Sophie, Treguer, Damien, de Plater, Ludmilla, Zemoura, Leïla, Némati, Fariba, Nicolas, André, Chapelier, Alain, Livartowski, Alain, Cairo, Stefano, Daniel, Catherine, Brevet, Marie, Marangoni, Elisabetta, Meseure, Didier, Roman-Roman, Sergio, Bieche, Ivan, Girard, Nicolas, Decaudin, Didier
Publicado 2021

Homologous recombination deficiency derived from whole-genome sequencing predicts platinum response in triple-negative breast cancers

por ter Brugge, Petra, Moser, Sarah C., Bièche, Ivan, Kristel, Petra, Ibadioune, Sabrina, Eeckhoutte, Alexandre, de Bruijn, Roebi, van der Burg, Eline, Lutz, Catrin, Annunziato, Stefano, de Ruiter, Julian, Masliah Planchon, Julien, Vacher, Sophie, Courtois, Laura, El-Botty, Rania, Dahmani, Ahmed, Montaudon, Elodie, Morisset, Ludivine, Sourd, Laura, Huguet, Léa, Derrien, Heloise, Nemati, Fariba, Chateau-Joubert, Sophie, Larcher, Thibaut, Salomon, Anne, Decaudin, Didier, Reyal, Fabien, Coussy, Florence, Popova, Tatiana, Wesseling, Jelle, Stern, Marc-Henri, Jonkers, Jos, Marangoni, Elisabetta
Publicado 2023

PLK1 inhibition exhibits strong anti-tumoral activity in CCND1-driven breast cancer metastases with acquired palbociclib resistance

por Montaudon, Elodie, Nikitorowicz-Buniak, Joanna, Sourd, Laura, Morisset, Ludivine, El Botty, Rania, Huguet, Léa, Dahmani, Ahmed, Painsec, Pierre, Nemati, Fariba, Vacher, Sophie, Chemlali, Walid, Masliah-Planchon, Julien, Château-Joubert, Sophie, Rega, Camilla, Leal, Mariana Ferreira, Simigdala, Nikiana, Pancholi, Sunil, Ribas, Ricardo, Nicolas, André, Meseure, Didier, Vincent-Salomon, Anne, Reyes, Cécile, Rapinat, Audrey, Gentien, David, Larcher, Thibaut, Bohec, Mylène, Baulande, Sylvain, Bernard, Virginie, Decaudin, Didier, Coussy, Florence, Le Romancer, Muriel, Dutertre, Guillaume, Tariq, Zakia, Cottu, Paul, Driouch, Keltouma, Bièche, Ivan, Martin, Lesley-Ann, Marangoni, Elisabetta
Publicado 2020