Pramipexole Reduces Phosphorylation of α-Synuclein at Serine-129

por Chau, Kai-Yin, Cooper, J. Mark, Schapira, Anthony Henry V.
Publicado 2013

Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models

por Hong, Chien Tai, Chau, Kai-Yin, Schapira, Anthony H. V.
Publicado 2016

The Cytomegalovirus protein pUL37×1 targets mitochondria to mediate neuroprotection

por Hong, Chien Tai, Chau, Kai-Yin, Schapira, Anthony H. V.
Publicado 2016

Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin‐mediated mitophagy

por Ivankovic, Davor, Chau, Kai‐Yin, Schapira, Anthony H. V., Gegg, Matthew E.
Publicado 2015

PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy

por Pryde, Kenneth R., Smith, Heather L., Chau, Kai-Yin, Schapira, Anthony H.V.
Publicado 2016

Neuroprotection in Glaucoma: NAD(+)/NADH Redox State as a Potential Biomarker and Therapeutic Target

por Petriti, Bledi, Williams, Pete A., Lascaratos, Gerassimos, Chau, Kai-Yin, Garway-Heath, David F.
Publicado 2021

A Human Neural Crest Stem Cell-Derived Dopaminergic Neuronal Model Recapitulates Biochemical Abnormalities in GBA1 Mutation Carriers

por Yang, Shi-Yu, Beavan, Michelle, Chau, Kai-Yin, Taanman, Jan-Willem, Schapira, Anthony H.V.
Publicado 2017

The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines

por Smith, Laura J, Bolsinger, Magdalena M, Chau, Kai-Yin, Gegg, Matthew E, Schapira, Anthony H V
Publicado 2022

Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models

por Sanchez-Martinez, Alvaro, Beavan, Michelle, Gegg, Matthew E., Chau, Kai-Yin, Whitworth, Alexander J., Schapira, Anthony H. V.
Publicado 2016

The Role of Mitophagy in Glaucomatous Neurodegeneration

por Stavropoulos, Dimitrios, Grewal, Manjot K., Petriti, Bledi, Chau, Kai-Yin, Hammond, Christopher J., Garway-Heath, David F., Lascaratos, Gerassimos
Publicado 2023

α-Synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells: an in vitro proof of concept study

por Hurley, Michael J, Menozzi, Elisa, Koletsi, Sofia, Bates, Rachel, Gegg, Matthew E, Chau, Kai-Yin, Blottière, Hervé M, Macnaughtan, Jane, Schapira, Anthony H V
Publicado 2023

Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling

por Hong, Chien-Tai, Chen, Kai-Yun, Wang, Weu, Chiu, Jing-Yuan, Wu, Dean, Chao, Tsu-Yi, Hu, Chaur-Jong, Chau, Kai-Yin David, Bamodu, Oluwaseun Adebayo
Publicado 2020

Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage

por Cleeter, Michael W.J., Chau, Kai-Yin, Gluck, Caroline, Mehta, Atul, Hughes, Derralynn A., Duchen, Michael, Wood, Nicholas William, Hardy, John, Mark Cooper, J., Schapira, Anthony Henry
Publicado 2013

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells

por McNeill, Alisdair, Magalhaes, Joana, Shen, Chengguo, Chau, Kai-Yin, Hughes, Derralyn, Mehta, Atul, Foltynie, Tom, Cooper, J. Mark, Abramov, Andrey Y., Gegg, Matthew, Schapira, Anthony H.V.
Publicado 2014

GBA mutation promotes early mitochondrial dysfunction in 3D neurosphere models

por Morén, Constanza, Juárez-Flores, Diana Luz, Chau, Kai-Yin, Gegg, Matthew, Garrabou, Glòria, González-Casacuberta, Ingrid, Guitart-Mampel, Mariona, Tolosa, Eduardo, Martí, María José, Cardellach, Francesc, Schapira, Anthony Henry Vernon
Publicado 2019

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

por Papkovskaia, Tatiana D., Chau, Kai-Yin, Inesta-Vaquera, Francisco, Papkovsky, Dmitri B., Healy, Daniel G., Nishio, Koji, Staddon, James, Duchen, Michael R., Hardy, John, Schapira, Anthony H.V., Cooper, J. Mark
Publicado 2012