Specificity and disease in the ubiquitin system

por Chaugule, Viduth K., Walden, Helen
Publicado 2016

Small, N-Terminal Tags Activate Parkin E3 Ubiquitin Ligase Activity by Disrupting Its Autoinhibited Conformation

por Burchell, Lynn, Chaugule, Viduth K., Walden, Helen
Publicado 2012

Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1

por Arkinson, Connor, Chaugule, Viduth K, Toth, Rachel, Walden, Helen
Publicado 2018

Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site

por Rennie, Martin L., Arkinson, Connor, Chaugule, Viduth K., Walden, Helen
Publicado 2022

Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening

por Morreale, Francesca E., Bortoluzzi, Alessio, Chaugule, Viduth K., Arkinson, Connor, Walden, Helen, Ciulli, Alessio
Publicado 2017

Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements

por Morreale, Francesca E., Testa, Andrea, Chaugule, Viduth K., Bortoluzzi, Alessio, Ciulli, Alessio, Walden, Helen
Publicado 2017

Allosteric mechanism for site-specific ubiquitination of FANCD2

por Chaugule, Viduth K., Arkinson, Connor, Rennie, Martin L., Kämäräinen, Outi, Toth, Rachel, Walden, Helen
Publicado 2019

Structural and biochemical basis of interdependent FANCI‐FANCD2 ubiquitination

por Lemonidis, Kimon, Rennie, Martin L, Arkinson, Connor, Chaugule, Viduth K, Clarke, Mairi, Streetley, James, Walden, Helen
Publicado 2022

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA

por Rennie, Martin L, Lemonidis, Kimon, Arkinson, Connor, Chaugule, Viduth K, Clarke, Mairi, Streetley, James, Spagnolo, Laura, Walden, Helen
Publicado 2020

DHX15 regulates CMTR1-dependent gene expression and cell proliferation

por Inesta-Vaquera, Francisco, Chaugule, Viduth K, Galloway, Alison, Chandler, Laurel, Rojas-Fernandez, Alejandro, Weidlich, Simone, Peggie, Mark, Cowling, Victoria H
Publicado 2018

The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL

por Miles, Jennifer A., Frost, Mark G., Carroll, Eilis, Rowe, Michelle L., Howard, Mark J., Sidhu, Ateesh, Chaugule, Viduth K., Alpi, Arno F., Walden, Helen
Publicado 2015

Parkin-phosphoubiquitin complex reveals a cryptic ubiquitin binding site required for RBR ligase activity

por Kumar, Atul, Chaugule, Viduth K, Condos, Tara E C, Barber, Kathryn R, Johnson, Clare, Toth, Rachel, Sundaramoorthy, Ramasubramanian, Knebel, Axel, Shaw, Gary S, Walden, Helen
Publicado 2017

RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation

por Bustos, Francisco, Segarra-Fas, Anna, Chaugule, Viduth K., Brandenburg, Lennart, Branigan, Emma, Toth, Rachel, Macartney, Thomas, Knebel, Axel, Hay, Ronald T., Walden, Helen, Findlay, Greg M.
Publicado 2018

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation

por Condos, Tara EC, Dunkerley, Karen M, Freeman, E Aisha, Barber, Kathryn R, Aguirre, Jacob D, Chaugule, Viduth K, Xiao, Yiming, Konermann, Lars, Walden, Helen, Shaw, Gary S
Publicado 2018

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis

por Kumar, Atul, Aguirre, Jacob D, Condos, Tara EC, Martinez-Torres, R Julio, Chaugule, Viduth K, Toth, Rachel, Sundaramoorthy, Ramasubramanian, Mercier, Pascal, Knebel, Axel, Spratt, Donald E, Barber, Kathryn R, Shaw, Gary S, Walden, Helen
Publicado 2015

Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity

por Altas, Bekir, Rhee, Hong-Jun, Ju, Anes, Solís, Hugo Cruces, Karaca, Samir, Winchenbach, Jan, Kaplan-Arabaci, Oykum, Schwark, Manuela, Ambrozkiewicz, Mateusz C., Lee, ChungKu, Spieth, Lena, Wieser, Georg L., Chaugule, Viduth K., Majoul, Irina, Hassan, Mohamed A., Goel, Rashi, Wojcik, Sonja M., Koganezawa, Noriko, Hanamura, Kenji, Rotin, Daniela, Pichler, Andrea, Mitkovski, Miso, de Hoz, Livia, Poulopoulos, Alexandros, Urlaub, Henning, Jahn, Olaf, Saher, Gesine, Brose, Nils, Rhee, JeongSeop, Kawabe, Hiroshi
Publicado 2023