The novel high-affinity humanized antibody IMM40H targets CD70, eliminates tumors via Fc-mediated effector functions, and interrupts CD70/CD27 signaling

por Li, Song, Chen, Dianze, Guo, Huiqin, Liu, Dandan, Yang, Chunmei, Zhang, Ruliang, Wang, Tianxiang, Zhang, Fan, Bai, Xing, Yang, Yanan, Sun, Nana, Zhang, Wei, Zhang, Li, Zhao, Gui, Peng, Liang, Tu, Xiaoping, Tian, Wenzhi
Publicado 2023

Crystal Structure of Human CD47 in Complex with Engineered SIRPα.D1(N80A)

por Yu, Jifeng, Li, Song, Chen, Dianze, Liu, Dandan, Guo, Huiqin, Yang, Chunmei, Zhang, Wei, Zhang, Li, Zhao, Gui, Tu, Xiaoping, Peng, Liang, Liu, Sijin, Bai, Xing, Song, Yongping, Jiang, Zhongxing, Zhang, Ruliang, Tian, Wenzhi
Publicado 2022

SIRPα-Fc fusion protein IMM01 exhibits dual anti-tumor activities by targeting CD47/SIRPα signal pathway via blocking the “don’t eat me” signal and activating the “eat me” signal...

por Yu, Jifeng, Li, Song, Chen, Dianze, Liu, Dandan, Guo, Huiqin, Yang, Chunmei, Zhang, Wei, Zhang, Li, Zhao, Gui, Tu, Xiaoping, Peng, Liang, Liu, Sijin, Bai, Xing, Song, Yongping, Jiang, Zhongxing, Zhang, Ruliang, Tian, Wenzhi
Publicado 2022

IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRPα, exerts excellent cancer killing efficacy by activating both macrophages and NK cells via blockade of CD...

por Yu, Jifeng, Li, Song, Chen, Dianze, Liu, Dandan, Guo, Huiqin, Yang, Chunmei, Zhang, Wei, Zhang, Li, Zhao, Gui, Tu, Xiaoping, Peng, Liang, Liu, Sijin, Bai, Xing, Song, Yongping, Jiang, Zhongxing, Zhang, Ruliang, Tian, Wenzhi
Publicado 2022

IMM47, a humanized monoclonal antibody that targets CD24, exhibits exceptional anti-tumor efficacy by blocking the CD24/Siglec-10 interaction and can be used as monotherapy or in c...

por Li, Song, Chen, Dianze, Guo, Huiqin, Yang, Yanan, Liu, Dandan, Yang, Chunmei, Bai, Xing, Zhang, Wei, Zhang, Li, Zhao, Gui, Tu, Xiaoping, Peng, Liang, Liu, Sijin, Song, Yongping, Jiang, Zhongxing, Zhang, Ruliang, Yu, Jifeng, Tian, Wenzhi
Publicado 2023