Directed Evolution of a Nonheme Diiron N-oxygenase AzoC for Improving Its Catalytic Efficiency toward Nitrogen Heterocycle Substrates

por Xu, Ye, Liu, Xiao-Fang, Chen, Xin-Ai, Li, Yong-Quan
Publicado 2022

Improvement of FK506 production via metabolic engineering-guided combinational strategies in Streptomyces tsukubaensis

por Wu, Qing-Bin, Zhang, Xiao-Ying, Chen, Xin-Ai, Li, Yong-Quan
Publicado 2021

A Novel Zn(2)Cys(6) Transcription Factor, TopC, Positively Regulates Trichodin A and Asperpyridone A Biosynthesis in Tolypocladium ophioglossoides

por Liu, Xiang, Li, Rui-Qi, Zeng, Qing-Xin, Li, Yong-Quan, Chen, Xin-Ai
Publicado 2023

Genomic and transcriptomic survey of an endophytic fungus Calcarisporium arbuscula NRRL 3705 and potential overview of its secondary metabolites

por Cheng, Jin-Tao, Cao, Fei, Chen, Xin-Ai, Li, Yong-Quan, Mao, Xu-Ming
Publicado 2020

Activation and Characterization of Lanthomicins A–C by Promoter Engineering in Streptomyces chattanoogensis L10

por Liu, Xiao-Fang, Wang, Jun-Xiao, Chen, Xin-Ai, Liu, Yu, Li, Yong-Quan
Publicado 2022

Gram-Level Production of Balanol through Regulatory Pathway and Medium Optimization in Herb Fungus Tolypocladium ophioglossoides

por Li, Rui-Qi, Liu, Xiang, Zhang, Min, Xu, Wei-Qun, Li, Yong-Quan, Chen, Xin-Ai
Publicado 2022

Redirection of acyl donor metabolic flux for lipopeptide A40926B0 biosynthesis

por Xia, Tian‐Yu, Chen, Xin‐Ai, Liu, Yan‐Qiu, Scharf, Daniel H., Zhao, Qing‐Wei, Li, Yong‐Quan
Publicado 2022

Rational construction of genome-reduced and high-efficient industrial Streptomyces chassis based on multiple comparative genomic approaches

por Bu, Qing-Ting, Yu, Pin, Wang, Jue, Li, Zi-Yue, Chen, Xin-Ai, Mao, Xu-Ming, Li, Yong-Quan
Publicado 2019

Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups

por Shen, Jie-Jie, Chen, Fu, Wang, Xiao-Xuan, Liu, Xiao-Fang, Chen, Xin-Ai, Mao, Xu-Ming, Li, Yong-Quan
Publicado 2018

Crotonylation of key metabolic enzymes regulates carbon catabolite repression in Streptomyces roseosporus

por Sun, Chen-Fan, Xu, Wei-Feng, Zhao, Qing-Wei, Luo, Shuai, Chen, Xin-Ai, Li, Yong-Quan, Mao, Xu-Ming
Publicado 2020

Comprehensive dissection of dispensable genomic regions in Streptomyces based on comparative analysis approach

por Bu, Qing-Ting, Li, Yue-Ping, Xie, Huang, Wang, Jue, Li, Zi-Yue, Chen, Xin-Ai, Mao, Xu-Ming, Li, Yong-Quan
Publicado 2020

Multi-Layer Controls of Cas9 Activity Coupled With ATP Synthase Over-Expression for Efficient Genome Editing in Streptomyces

por Wang, Kai, Zhao, Qing-Wei, Liu, Yi-Fan, Sun, Chen-Fan, Chen, Xin-Ai, Burchmore, Richard, Burgess, Karl, Li, Yong-Quan, Mao, Xu-Ming
Publicado 2019

m4C DNA methylation regulates biosynthesis of daptomycin in Streptomyces roseosporus L30

por Fang, Jiao-Le, Gao, Wen-Li, Xu, Wei-Feng, Lyu, Zhong-Yuan, Ma, Lie, Luo, Shuai, Chen, Xin-Ai, Mao, Xu-Ming, Li, Yong-Quan
Publicado 2022

Improving the Yield and Quality of Daptomycin in Streptomyces roseosporus by Multilevel Metabolic Engineering

por Lyu, Zhong-Yuan, Bu, Qing-Ting, Fang, Jiao-Le, Zhu, Chen-Yang, Xu, Wei-Feng, Ma, Lie, Gao, Wen-Li, Chen, Xin-Ai, Li, Yong-Quan
Publicado 2022