A quantitative systems pharmacology approach, incorporating a novel liver model, for predicting pharmacokinetic drug-drug interactions

por Cherkaoui-Rbati, Mohammed H., Paine, Stuart W., Littlewood, Peter, Rauch, Cyril
Publicado 2017

New In Vitro Interaction-Parasite Reduction Ratio Assay for Early Derisk in Clinical Development of Antimalarial Combinations

por Wicha, Sebastian G., Walz, Annabelle, Cherkaoui-Rbati, Mohammed H., Bundgaard, Nils, Kuritz, Karsten, Gumpp, Christin, Gobeau, Nathalie, Möhrle, Jörg, Rottmann, Matthias, Demarta-Gatsi, Claudia
Publicado 2022

A pharmacokinetic–pharmacodynamic model for chemoprotective agents against malaria

por Cherkaoui‐Rbati, Mohammed H., Andenmatten, Nicole, Burgert, Lydia, Egbelowo, Oluwaseun F., Fendel, Rolf, Fornari, Chiara, Gabel, Michael, Ward, John, Möhrle, Jörg J., Gobeau, Nathalie
Publicado 2022

A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of th...

por McCarthy, James S, Donini, Cristina, Chalon, Stephan, Woodford, John, Marquart, Louise, Collins, Katharine A, Rozenberg, Felix D, Fidock, David A, Cherkaoui-Rbati, Mohammed H, Gobeau, Nathalie, Möhrle, Jörg J
Publicado 2020

The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro

por Walz, Annabelle, Duffey, Maëlle, Aljayyoussi, Ghaith, Sax, Sibylle, Leroy, Didier, Besson, Dominique, Burrows, Jeremy N., Cherkaoui-Rbati, Mohammed H., Gobeau, Nathalie, Westwood, Marie-Anne, Siethoff, Christoph, Gamo, Francisco-Javier, Mäser, Pascal, Wittlin, Sergio
Publicado 2023

Parasite Viability as a Measure of In Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment

por Radohery, Georges F. R., Walz, Annabelle, Gumpp, Christin, Cherkaoui-Rbati, Mohammed H., Gobeau, Nathalie, Gower, Jeremy, Davenport, Miles P., Rottmann, Matthias, McCarthy, James S., Möhrle, Jörg J., Rebelo, Maria, Demarta-Gatsi, Claudia, Khoury, David S.
Publicado 2022

Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study

por Chughlay, Mohamed Farouk, El Gaaloul, Myriam, Donini, Cristina, Campo, Brice, Berghmans, Pieter-Jan, Lucardie, Alexander, Marx, Michael W., Cherkaoui-Rbati, Mohammed H., Langdon, Grant, Angulo-Barturen, Iñigo, Viera, Sara, Rosanas-Urgell, Anna, Van Geertruyden, Jean-Pierre, Chalon, Stephan
Publicado 2021

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults...

por Adoke, Yeka, Zoleko-Manego, Rella, Ouoba, Serge, Tiono, Alfred B., Kaguthi, Grace, Bonzela, Juvêncio Eduardo, Duong, Tran Thanh, Nahum, Alain, Bouyou-Akotet, Marielle, Ogutu, Bernhards, Ouedraogo, Alphonse, Macintyre, Fiona, Jessel, Andreas, Laurijssens, Bart, Cherkaoui-Rbati, Mohammed H., Cantalloube, Cathy, Marrast, Anne Claire, Bejuit, Raphaël, White, David, Wells, Timothy N. C., Wartha, Florian, Leroy, Didier, Kibuuka, Afizi, Mombo-Ngoma, Ghyslain, Ouattara, Daouda, Mugenya, Irène, Phuc, Bui Quang, Bohissou, Francis, Mawili-Mboumba, Denise P., Olewe, Fredrick, Soulama, Issiaka, Tinto, Halidou
Publicado 2021