Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides

por Zakharenko, Alexandra L., Drenichev, Mikhail S., Dyrkheeva, Nadezhda S., Ivanov, Georgy A., Oslovsky, Vladimir E., Ilina, Ekaterina S., Chernyshova, Irina A., Lavrik, Olga I., Mikhailov, Sergey N.
Publicado 2020

In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistr...

por Dyrkheeva, Nadezhda S., Chernyshova, Irina A., Ivanov, Georgy A., Porozov, Yuri B., Zenchenko, Anastasia A., Oslovsky, Vladimir E., Zakharenko, Alexandra L., Nasyrova, Darina I., Likhatskaya, Galina N., Mikhailov, Sergey N., Lavrik, Olga I., Drenichev, Mikhail S.
Publicado 2022

The Lipophilic Purine Nucleoside—Tdp1 Inhibitor—Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo

por Chernyshova, Irina A., Zakharenko, Aleksandra L., Kurochkin, Nikolay N., Dyrkheeva, Nadezhda S., Kornienko, Tatyana E., Popova, Nelly A., Nikolin, Valeriy P., Ilina, Ekaterina S., Zharkov, Timofey D., Kupryushkin, Maxim S., Oslovsky, Vladimir E., Drenichev, Mikhail S., Lavrik, Olga I.
Publicado 2022

New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1

por Dyrkheeva, Nadezhda S., Filimonov, Aleksandr S., Luzina, Olga A., Orlova, Kristina A., Chernyshova, Irina A., Kornienko, Tatyana E., Malakhova, Anastasia A., Medvedev, Sergey P., Zakharenko, Alexandra L., Ilina, Ekaterina S., Anarbaev, Rashid O., Naumenko, Konstantin N., Klabenkova, Kristina V., Burakova, Ekaterina A., Stetsenko, Dmitry A., Zakian, Suren M., Salakhutdinov, Nariman F., Lavrik, Olga I.
Publicado 2021