Targeting MYCN and ALK in resistant and relapsing neuroblastoma

por Tucker, Elizabeth R, Poon, Evon, Chesler, Louis
Publicado 2019

Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges Ahead

por Shrestha, Sumana, Morcavallo, Alaide, Gorrini, Chiara, Chesler, Louis
Publicado 2021

The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma

por Tucker, Elizabeth R., George, Sally, Angelini, Paola, Bruna, Alejandra, Chesler, Louis
Publicado 2021

Liquid biopsy for children with central nervous system tumours: Clinical integration and technical considerations

por Stankunaite, Reda, Marshall, Lynley V., Carceller, Fernando, Chesler, Louis, Hubank, Michael, George, Sally L.
Publicado 2022

miRNA Expression Profiling of the Murine TH-MYCN Neuroblastoma Model Reveals Similarities with Human Tumors and Identifies Novel Candidate MiRNAs

por Terrile, Marta, Bryan, Kenneth, Vaughan, Lynsey, Hallsworth, Albert, Webber, Hannah, Chesler, Louis, Stallings, Raymond L.
Publicado 2011

Molecular and In Vivo Characterization of Cancer-Propagating Cells Derived from MYCN-Dependent Medulloblastoma

por Ahmad, Zai, Jasnos, Lukasz, Gil, Veronica, Howell, Louise, Hallsworth, Albert, Petrie, Kevin, Sawado, Tomoyuki, Chesler, Louis
Publicado 2015

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity

por Watts, Ellen, Heidenreich, David, Tucker, Elizabeth, Raab, Monika, Strebhardt, Klaus, Chesler, Louis, Knapp, Stefan, Bellenie, Benjamin, Hoelder, Swen
Publicado 2019

Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer

por Cage, Tene Aneka, Chanthery, Yvan, Chesler, Louis, Grimmer, Matthew, Knight, Zachary, Shokat, Kevan, Weiss, William A., Gustafson, W. Clay
Publicado 2015

Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on‐target ALK inhibitors in neuroblastoma

por Tucker, Elizabeth R., Tall, Jennifer R., Danielson, Laura S., Gowan, Sharon, Jamin, Yann, Robinson, Simon P., Banerji, Udai, Chesler, Louis
Publicado 2017

Intrinsic Susceptibility MRI Identifies Tumors with ALK(F1174L) Mutation in Genetically-Engineered Murine Models of High-Risk Neuroblastoma

por Jamin, Yann, Glass, Laura, Hallsworth, Albert, George, Rani, Koh, Dow-Mu, Pearson, Andrew D. J., Chesler, Louis, Robinson, Simon P.
Publicado 2014

Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform

por Almeida, Gilberto S, Panek, Rafal, Hallsworth, Albert, Webber, Hannah, Papaevangelou, Efthymia, Boult, Jessica KR, Jamin, Yann, Chesler, Louis, Robinson, Simon P
Publicado 2017

(18)F-meta-fluorobenzylguanidine ((18)F-mFBG) to monitor changes in norepinephrine transporter expression in response to therapeutic intervention in neuroblastoma models

por Turnock, Stephen, Turton, David R., Martins, Carlos Daniel, Chesler, Louis, Wilson, Thomas C., Gouverneur, Véronique, Smith, Graham, Kramer-Marek, Gabriela
Publicado 2020

Systemic oncolytic adenovirus delivered in mesenchymal carrier cells modulate tumor infiltrating immune cells and tumor microenvironment in mice with neuroblastoma

por Franco-Luzón, Lidia, González-Murillo, África, Alcántara-Sánchez, Cristina, García-García, Lorena, Tabasi, Maryam, Huertas, Ana Luis, Chesler, Louis, Ramírez, Manuel
Publicado 2020

MBRS-57. IDENTIFICATION OF MYC-DEPENDENT THERAPEUTIC VULNERABILITIES FOR TARGETING GROUP 3 MEDULLOBLASTOMA

por Llargués-Sistac, Gemma, Lindsey, Janet, Swartz, Shanel, Selby, Matthew, Morcavallo, Alaide, Bailey, Simon, Chesler, Louis, Lord, Christopher J, Williamson, Daniel, Clifford, Steven C
Publicado 2020

The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme

por Urban-Wójciuk, Zuzanna, Graham, Amy, Barker, Karen, Kwok, Colin, Sbirkov, Yordan, Howell, Louise, Campbell, James, Woster, Patrick M., Poon, Evon, Petrie, Kevin, Chesler, Louis
Publicado 2021

MBRS-33. TEMPORARY RESTORATION OF p53 ACTIVITY DURING FRACTIONATED RADIOTHERAPY IN A GROUP3 MEDULLOBLASTOMA GEMM REPRESENTS A POWERFUL TOOL FOR RADIOBIOLOGY STUDIES

por Morcavallo, Alaide, Mandeville, Henry, Barker, Karen, Richardson, Stacey, Lindsey, Janet, Lockett, Nikita, Boult, Jessica K R, Robinson, Simon P, Oelfke, Uwe, Williamson, Daniel, Clifford, Steven C, Chesler, Louis
Publicado 2020

Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus

por Gonzalez Malagon, Sandra G., Lopez Muñoz, Anna M., Doro, Daniel, Bolger, Triòna G., Poon, Evon, Tucker, Elizabeth R., Adel Al-Lami, Hadeel, Krause, Matthias, Phiel, Christopher J., Chesler, Louis, Liu, Karen J.
Publicado 2018

Subclonal reconstruction of tumors using machine learning and population genetics

por Caravagna, Giulio, Heide, Timon, Williams, Marc J., Zapata, Luis, Nichol, Daniel, Chkhaidze, Ketevan, Cross, William, Cresswell, George D., Werner, Benjamin, Acar, Ahmet, Chesler, Louis, Barnes, Chris P., Sanguinetti, Guido, Graham, Trevor A., Sottoriva, Andrea
Publicado 2020

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

por Moore, Nathan F., Azarova, Anna M., Bhatnagar, Namrata, Ross, Kenneth N., Drake, Lauren E., Frumm, Stacey, Liu, Qinsong S., Christie, Amanda L., Sanda, Takaomi, Chesler, Louis, Kung, Andrew L., Gray, Nathanael S., Stegmaier, Kimberly, George, Rani E.
Publicado 2014

MEDB-79. MYC-driven upregulation of thede novo serine and glycine pathway is a novel therapeutic target for Group 3 MYC-amplified Medulloblastoma

por Adiamah, Magretta, Lindsey, Janet C, Burté, Florence, Kohe, Sarah, Morcavallo, Alaide, Blair, Helen, Hill, Rebecca M, Singh, Mankaran, Crosier, Stephen, Zhang, Tong, Maddocks, Oliver, Peet, Andrew, Chesler, Louis, Hickson, Ian, Maxwell, Ross, Clifford, Steven C
Publicado 2022