Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro

por Aslan, Ozlem, Cremona, Mattia, Morgan, Clare, Cheung, Lydia W., Mills, Gordon B., Hennessy, Bryan T.
Publicado 2018

Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases

por Li, Xinran, Lau, Amy Y. T., Ng, Angel S. N., Aldehaiman, Abdullah, Zhou, Yuan, Ng, Patrick K. S., Arold, Stefan T., Cheung, Lydia W. T.
Publicado 2021

Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer

por Li, Xinran, Mak, Victor C. Y., Zhou, Yuan, Wang, Chao, Wong, Esther S. Y., Sharma, Rakesh, Lu, Yiling, Cheung, Annie N. Y., Mills, Gordon B., Cheung, Lydia W. T.
Publicado 2019

AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance

por Ng, Angel S.N., Zhang, Shibo, Mak, Victor C.Y., Zhou, Yuan, Yuen, Yin, Sharma, Rakesh, Lu, Yiling, Zhuang, Guanglei, Zhao, Wei, Pang, Herbert H., Cheung, Lydia W.T.
Publicado 2022

Somatic Mutations of PIK3R1 Promote Gliomagenesis

por Quayle, Steven N., Lee, Jennifer Y., Cheung, Lydia W T., Ding, Li, Wiedemeyer, Ruprecht, Dewan, Robert W., Huang-Hobbs, Emmet, Zhuang, Li, Wilson, Richard K., Ligon, Keith L., Mills, Gordon B., Cantley, Lewis C., Chin, Lynda
Publicado 2012

p85β regulates autophagic degradation of AXL to activate oncogenic signaling

por Rao, Ling, Mak, Victor C. Y., Zhou, Yuan, Zhang, Dong, Li, Xinran, Fung, Chloe C. Y., Sharma, Rakesh, Gu, Chao, Lu, Yiling, Tipoe, George L., Cheung, Annie N. Y., Mills, Gordon B., Cheung, Lydia W. T.
Publicado 2020

Therapeutic targeting of CPSF3-dependent transcriptional termination in ovarian cancer

por Shen, Peiye, Ye, Kaiyan, Xiang, Huaijiang, Zhang, Zhenfeng, He, Qinyang, Zhang, Xiao, Cai, Mei-Chun, Chen, Junfei, Sun, Yunheng, Lin, Lifeng, Qi, Chunting, Zhang, Meiying, Cheung, Lydia W. T., Shi, Tingyan, Yin, Xia, Li, Ying, Di, Wen, Zang, Rongyu, Tan, Li, Zhuang, Guanglei
Publicado 2023

Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer

por Liang, Han, Cheung, Lydia W.T., Li, Jie, Ju, Zhenlin, Yu, Shuangxing, Stemke-Hale, Katherine, Dogruluk, Turgut, Lu, Yiling, Liu, Xiuping, Gu, Chao, Guo, Wei, Scherer, Steven E., Carter, Hannah, Westin, Shannon N., Dyer, Mary D., Verhaak, Roeland G.W., Zhang, Fan, Karchin, Rachel, Liu, Chang-Gong, Lu, Karen H., Broaddus, Russell R., Scott, Kenneth L., Hennessy, Bryan T., Mills, Gordon B.
Publicado 2012

The impact of the multi-disciplinary molecular tumour board and integrative next generation sequencing on clinical outcomes in advanced solid tumours

por El Helali, Aya, Lam, Tai-Chung, Ko, Elaine Yee-Ling, Shih, David J.H., Chan, Chun Kau, Wong, Charlene H.L., Wong, Jason W.H., Cheung, Lydia W.T., Lau, Johnny K.S., Liu, Anthony P.Y., Chan, Ann S.Y., Loong, Herbert H., Lam, Stephen Tak Sum, Chan, Godfrey Chi-Fung, Lee, Victor H.F., Yuen, Kwok Keung, Ng, Wai-Tong, Lee, Anne W.M., Ma, Edmond S.K.
Publicado 2023