Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

por Rudenko, Iakov N, Chia, Ruth, Cookson, Mark R
Publicado 2012

Unraveling the complex interplay between genes, environment, and climate in ALS

por Vasta, Rosario, Chia, Ruth, Traynor, Bryan J., Chiò, Adriano
Publicado 2021

The Overlapping Genetics of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

por Abramzon, Yevgeniya A., Fratta, Pietro, Traynor, Bryan J., Chia, Ruth
Publicado 2020

Reply to Zhu et al.: Implications of CHRNB1 and ERBB2 in the pathobiology of myasthenia gravis

por Chia, Ruth, Saez-Atienzar, Sara, Drachman, Daniel B., Traynor, Bryan J.
Publicado 2022

Superoxide Dismutase 1 and tgSOD1(G93A) Mouse Spinal Cord Seed Fibrils, Suggesting a Propagative Cell Death Mechanism in Amyotrophic Lateral Sclerosis

por Chia, Ruth, Tattum, M. Howard, Jones, Samantha, Collinge, John, Fisher, Elizabeth M. C., Jackson, Graham S.
Publicado 2010

Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution

por Mamais, Adamantios, Chia, Ruth, Beilina, Alexandra, Hauser, David N., Hall, Christine, Lewis, Patrick A., Cookson, Mark R., Bandopadhyay, Rina
Publicado 2014

Mutant Glycyl-tRNA Synthetase (Gars) Ameliorates SOD1(G93A) Motor Neuron Degeneration Phenotype but Has Little Affect on Loa Dynein Heavy Chain Mutant Mice

por Banks, Gareth T., Bros-Facer, Virginie, Williams, Hazel P., Chia, Ruth, Achilli, Francesca, Bryson, J. Barney, Greensmith, Linda, Fisher, Elizabeth M. C.
Publicado 2009

Correction: Mutant Glycyl-tRNA Synthetase (Gars) Ameliorates SOD1(G93A) Motor Neuron Degeneration Phenotype but Has Little Affect on Loa Dynein Heavy Chain Mutant Mice

por Banks, Gareth T., Bros-Facer, Virginie, Williams, Hazel P., Chia, Ruth, Achilli, Francesca, Bryson, J. Barney, Greensmith, Linda, Fisher, Elizabeth M. C.
Publicado 2009

Improving vaccination uptake in pediatric Cochlear implant recipients

por Jin, Lisa, Téllez, Paula, Chia, Ruth, Lu, Daphne, Chadha, Neil K., Pauwels, Julie, Dobson, Simon, Al Eid, Hazim, Kozak, Frederick K.
Publicado 2018

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

por Chia, Ruth, Haddock, Sara, Beilina, Alexandra, Rudenko, Iakov N, Mamais, Adamantios, Kaganovich, Alice, Li, Yan, Kumaran, Ravindran, Nalls, Michael A, Cookson, Mark R
Publicado 2014

Combined epigenetic/genetic study identified an ALS age of onset modifier

por Zhang, Ming, Xi, Zhengrui, Saez-Atienzar, Sara, Chia, Ruth, Moreno, Danielle, Sato, Christine, Montazer Haghighi, Mahdi, Traynor, Bryan J., Zinman, Lorne, Rogaeva, Ekaterina
Publicado 2021

Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis

por Diaz-Garcia, Sandra, Ko, Vivian I., Vazquez-Sanchez, Sonia, Chia, Ruth, Arogundade, Olubankole Aladesuyi, Rodriguez, Maria J., Traynor, Bryan J., Cleveland, Don, Ravits, John
Publicado 2021

Modification of Superoxide Dismutase 1 (SOD1) Properties by a GFP Tag – Implications for Research into Amyotrophic Lateral Sclerosis (ALS)

por Stevens, James C., Chia, Ruth, Hendriks, William T., Bros-Facer, Virginie, van Minnen, Jan, Martin, Joanne E., Jackson, Graham S., Greensmith, Linda, Schiavo, Giampietro, Fisher, Elizabeth M. C.
Publicado 2010

ENU Mutagenesis Reveals a Novel Phenotype of Reduced Limb Strength in Mice Lacking Fibrillin 2

por Miller, Gaynor, Neilan, Monica, Chia, Ruth, Gheryani, Nabeia, Holt, Natalie, Charbit, Annabelle, Wells, Sara, Tucci, Valter, Lalanne, Zuzanne, Denny, Paul, Fisher, Elizabeth M. C., Cheeseman, Michael, Askew, Graham N., Dear, T. Neil
Publicado 2010

Systematic evaluation of genetic mutations in ALS: a population-based study

por Grassano, Maurizio, Calvo, Andrea, Moglia, Cristina, Sbaiz, Luca, Brunetti, Maura, Barberis, Marco, Casale, Federico, Manera, Umberto, Vasta, Rosario, Canosa, Antonio, D’Alfonso, Sandra, Corrado, Lucia, Mazzini, Letizia, Dalgard, Clifton, Karra, Ramita, Chia, Ruth, Traynor, Bryan, Chiò, Adriano
Publicado 2022

Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study

por Chia, Ruth, Saez-Atienzar, Sara, Murphy, Natalie, Chiò, Adriano, Blauwendraat, Cornelis, Roda, Ricardo H., Tienari, Pentti J., Kaminski, Henry J., Ricciardi, Roberta, Guida, Melania, De Rosa, Anna, Petrucci, Loredana, Evoli, Amelia, Provenzano, Carlo, Drachman, Daniel B., Traynor, Bryan J.
Publicado 2022

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types

por Saez-Atienzar, Sara, Bandres-Ciga, Sara, Langston, Rebekah G., Kim, Jonggeol J., Choi, Shing Wan, Reynolds, Regina H., Abramzon, Yevgeniya, Dewan, Ramita, Ahmed, Sarah, Landers, John E., Chia, Ruth, Ryten, Mina, Cookson, Mark R., Nalls, Michael A., Chiò, Adriano, Traynor, Bryan J.
Publicado 2021

A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation

por Law, Bernard M. H., Spain, Victoria A., Leinster, Veronica H. L., Chia, Ruth, Beilina, Alexandra, Cho, Hyun J., Taymans, Jean-Marc, Urban, Mary K., Sancho, Rosa M., Ramírez, Marian Blanca, Biskup, Saskia, Baekelandt, Veerle, Cai, Huaibin, Cookson, Mark R., Berwick, Daniel C., Harvey, Kirsten
Publicado 2014

Critical periods after stroke study: translating animal stroke recovery experiments into a clinical trial

por Dromerick, Alexander W., Edwardson, Matthew A., Edwards, Dorothy F., Giannetti, Margot L., Barth, Jessica, Brady, Kathaleen P., Chan, Evan, Tan, Ming T., Tamboli, Irfan, Chia, Ruth, Orquiza, Michael, Padilla, Robert M., Cheema, Amrita K., Mapstone, Mark E., Fiandaca, Massimo S., Federoff, Howard J., Newport, Elissa L.
Publicado 2015

Exploring the phenotype of Italian patients with ALS with intermediate ATXN2 polyQ repeats

por Chio, Adriano, Moglia, Cristina, Canosa, Antonio, Manera, Umberto, Grassano, Maurizio, Vasta, Rosario, Palumbo, Francesca, Gallone, Salvatore, Brunetti, Maura, Barberis, Marco, De Marchi, Fabiola, Dalgard, Clifton, Chia, Ruth, Mora, Gabriele, Iazzolino, Barbara, Peotta, Laura, Traynor, Bryan, Corrado, Lucia, D'Alfonso, Sandra, Mazzini, Letizia, Calvo, Andrea
Publicado 2022