Optimization of a small molecule inhibitor of secondary nucleation in α-synuclein aggregation

por Staats, Roxine, Brotzakis, Z. Faidon, Chia, Sean, Horne, Robert I., Vendruscolo, Michele
Publicado 2023

Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

por Ruggeri, Francesco Simone, Habchi, Johnny, Chia, Sean, Horne, Robert I., Vendruscolo, Michele, Knowles, Tuomas P. J.
Publicado 2021

Insight into muscle stem cell regeneration and mechanobiology

por Pang, Kuin Tian, Loo, Larry Sai Weng, Chia, Sean, Ong, Francesca Yi Teng, Yu, Hanry, Walsh, Ian
Publicado 2023

Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation

por Joshi, Priyanka, Chia, Sean, Yang, Xiaoting, Perni, Michele, Gabriel, Justus M., Gilmer, Marshall, Limbocker, Ryan, Habchi, Johnny, Vendruscolo, Michele
Publicado 2023

Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation

por Horne, Robert I., Murtada, Mhd Hussein, Huo, Donghui, Brotzakis, Z. Faidon, Gregory, Rebecca C., Possenti, Andrea, Chia, Sean, Vendruscolo, Michele
Publicado 2023

Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts

por Horne, Robert I., Metrick, Michael A., Man, Wing, Rinauro, Dillon J., Brotzakis, Z. Faidon, Chia, Sean, Meisl, Georg, Vendruscolo, Michele
Publicado 2023

Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response

por Joshi, Priyanka, Perni, Michele, Limbocker, Ryan, Mannini, Benedetta, Casford, Sam, Chia, Sean, Habchi, Johnny, Labbadia, Johnathan, Dobson, Christopher M., Vendruscolo, Michele
Publicado 2021

Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer’s disease via a cytosolic unfolded protein response

por Joshi, Priyanka, Perni, Michele, Limbocker, Ryan, Mannini, Benedetta, Casford, Sam, Chia, Sean, Habchi, Johnny, Labbadia, Johnathan, Dobson, Christopher M., Vendruscolo, Michele
Publicado 2021

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity

por Ruggeri, Francesco Simone, Charmet, Jerome, Kartanas, Tadas, Peter, Quentin, Chia, Sean, Habchi, Johnny, Dobson, Christopher M., Vendruscolo, Michele, Knowles, Tuomas P. J.
Publicado 2018

SAR by kinetics for drug discovery in protein misfolding diseases

por Chia, Sean, Habchi, Johnny, Michaels, Thomas C. T., Cohen, Samuel I. A., Linse, Sara, Dobson, Christopher M., Knowles, Tuomas P. J., Vendruscolo, Michele
Publicado 2018

An Integrative Glycomic Approach for Quantitative Meat Species Profiling

por Chia, Sean, Teo, Gavin, Tay, Shi Jie, Loo, Larry Sai Weng, Wan, Corrine, Sim, Lyn Chiin, Yu, Hanry, Walsh, Ian, Pang, Kuin Tian
Publicado 2022

Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation

por Delivoria, Dafni C., Chia, Sean, Habchi, Johnny, Perni, Michele, Matis, Ilias, Papaevgeniou, Nikoletta, Reczko, Martin, Chondrogianni, Niki, Dobson, Christopher M., Vendruscolo, Michele, Skretas, Georgios
Publicado 2019

Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter

por Staats, Roxine, Michaels, Thomas C. T., Flagmeier, Patrick, Chia, Sean, Horne, Robert I., Habchi, Johnny, Linse, Sara, Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele
Publicado 2020

Enhanced surface nanoanalytics of transient biomolecular processes

por Miller, Alyssa, Chia, Sean, Toprakcioglu, Zenon, Hakala, Tuuli, Schmid, Roman, Feng, Yaduo, Kartanas, Tadas, Kamada, Ayaka, Vendruscolo, Michele, Ruggeri, Francesco Simone, Knowles, Tuomas P. J.
Publicado 2023

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers

por Ghadami, Seyyed Abolghasem, Chia, Sean, Ruggeri, Francesco Simone, Meisl, Georg, Bemporad, Francesco, Habchi, Johnny, Cascella, Roberta, Dobson, Christopher M., Vendruscolo, Michele, Knowles, Tuomas P. J., Chiti, Fabrizio
Publicado 2020

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates

por Chia, Sean, Faidon Brotzakis, Z., Horne, Robert I., Possenti, Andrea, Mannini, Benedetta, Cataldi, Rodrigo, Nowinska, Magdalena, Staats, Roxine, Linse, Sara, Knowles, Tuomas P. J., Habchi, Johnny, Vendruscolo, Michele
Publicado 2022

Proliferation of Tau 304–380 Fragment Aggregates through Autocatalytic Secondary Nucleation

por Rodriguez Camargo, Diana C., Sileikis, Eimantas, Chia, Sean, Axell, Emil, Bernfur, Katja, Cataldi, Rodrigo L., Cohen, Samuel I. A., Meisl, Georg, Habchi, Johnny, Knowles, Tuomas P. J., Vendruscolo, Michele, Linse, Sara
Publicado 2021

Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores

por Sandler, Sarah E., Horne, Robert I., Rocchetti, Sara, Novak, Robert, Hsu, Nai-Shu, Castellana Cruz, Marta, Faidon Brotzakis, Z., Gregory, Rebecca C., Chia, Sean, Bernardes, Gonçalo J. L., Keyser, Ulrich F., Vendruscolo, Michele
Publicado 2023

Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates

por Rodriguez Camargo, Diana C., Chia, Sean, Menzies, Joseph, Mannini, Benedetta, Meisl, Georg, Lundqvist, Martin, Pohl, Christin, Bernfur, Katja, Lattanzi, Veronica, Habchi, Johnny, Cohen, Samuel IA, Knowles, Tuomas P. J, Vendruscolo, Michele, Linse, Sara
Publicado 2021

A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers

por Cataldi, Rodrigo, Chia, Sean, Pisani, Katarina, Ruggeri, Francesco S., Xu, Catherine K., Šneideris, Tomas, Perni, Michele, Sarwat, Sunehera, Joshi, Priyanka, Kumita, Janet R., Linse, Sara, Habchi, Johnny, Knowles, Tuomas P. J., Mannini, Benedetta, Dobson, Christopher M., Vendruscolo, Michele
Publicado 2021