Improving Protection to Prevent Bacterial Infections: Preliminary Applications of Reverse Vaccinology against the Main Cystic Fibrosis Pathogens

por Cocorullo, Mario, Chiarelli, Laurent R., Stelitano, Giovanni
Publicado 2023

Engineering of Helicobacter pylori L-Asparaginase: Characterization of Two Functionally Distinct Groups of Mutants

por Maggi, Maristella, Chiarelli, Laurent R., Valentini, Giovanna, Scotti, Claudia
Publicado 2015

Tackling Critical Catalytic Residues in Helicobacter pylori l-Asparaginase

por Maggi, Maristella, Chiarelli, Laurent R, Valentini, Giovanna, Scotti, Claudia
Publicado 2015

Structural Study of a New MbtI-Inhibitor Complex: Towards an Optimized Model for Structure-Based Drug Discovery

por Mori, Matteo, Villa, Stefania, Chiarelli, Laurent R., Meneghetti, Fiorella, Bellinzoni, Marco
Publicado 2023

Quorum Sensing as Antivirulence Target in Cystic Fibrosis Pathogens

por Scoffone, Viola Camilla, Trespidi, Gabriele, Chiarelli, Laurent R., Barbieri, Giulia, Buroni, Silvia
Publicado 2019

Biochemical Signatures of Doppel Protein in Human Astrocytomas to Support Prediction in Tumor Malignancy

por Rognoni, Paola, Chiarelli, Laurent R., Comincini, Sergio, Azzalin, Alberto, Miracco, Clelia, Valentini, Giovanna
Publicado 2010

Burkholderia cenocepacia Infections in Cystic Fibrosis Patients: Drug Resistance and Therapeutic Approaches

por Scoffone, Viola C., Chiarelli, Laurent R., Trespidi, Gabriele, Mentasti, Massimo, Riccardi, Giovanna, Buroni, Silvia
Publicado 2017

Molecular Insights on Pathogenic Effects of Mutations Causing Phosphoglycerate Kinase Deficiency

por Chiarelli, Laurent R., Morera, Simone M., Bianchi, Paola, Fermo, Elisa, Zanella, Alberto, Galizzi, Alessandro, Valentini, Giovanna
Publicado 2012

Mycobacterium abscessus Infections in Cystic Fibrosis Individuals: A Review on Therapeutic Options

por Recchia, Deborah, Stelitano, Giovanni, Stamilla, Alessandro, Gutierrez, Damaris L., Degiacomi, Giulia, Chiarelli, Laurent R., Pasca, Maria Rosalia
Publicado 2023

Mycobacterium tuberculosis Phosphoribosylpyrophosphate Synthetase: Biochemical Features of a Crucial Enzyme for Mycobacterial Cell Wall Biosynthesis

por Lucarelli, Anna P., Buroni, Silvia, Pasca, Maria R., Rizzi, Menico, Cavagnino, Andrea, Valentini, Giovanna, Riccardi, Giovanna, Chiarelli, Laurent R.
Publicado 2010

Synthesis, Characterization, and Biological Evaluation of New Derivatives Targeting MbtI as Antitubercular Agents

por Mori, Matteo, Stelitano, Giovanni, Chiarelli, Laurent R., Cazzaniga, Giulia, Gelain, Arianna, Barlocco, Daniela, Pini, Elena, Meneghetti, Fiorella, Villa, Stefania
Publicado 2021

Rv0579 Is Involved in the Resistance to the TP053 Antitubercular Prodrug

por Mori, Giorgia, Orena, Beatrice Silvia, Chiarelli, Laurent R., Degiacomi, Giulia, Riabova, Olga, Sammartino, José Camilla, Makarov, Vadim, Riccardi, Giovanna, Pasca, Maria Rosalia
Publicado 2020

Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study

por Buroni, Silvia, Scoffone, Viola C., Fumagalli, Marco, Makarov, Vadim, Cagnone, Maddalena, Trespidi, Gabriele, De Rossi, Edda, Forneris, Federico, Riccardi, Giovanna, Chiarelli, Laurent R.
Publicado 2018

Chemical, Metabolic, and Cellular Characterization of a FtsZ Inhibitor Effective Against Burkholderia cenocepacia

por Chiarelli, Laurent R., Scoffone, Viola Camilla, Trespidi, Gabriele, Barbieri, Giulia, Riabova, Olga, Monakhova, Natalia, Porta, Alessio, Manina, Giulia, Riccardi, Giovanna, Makarov, Vadim, Buroni, Silvia
Publicado 2020

Discovery of new diketopiperazines inhibiting Burkholderia cenocepacia quorum sensing in vitro and in vivo

por Scoffone, Viola C., Chiarelli, Laurent R., Makarov, Vadim, Brackman, Gilles, Israyilova, Aygun, Azzalin, Alberto, Forneris, Federico, Riabova, Olga, Savina, Svetlana, Coenye, Tom, Riccardi, Giovanna, Buroni, Silvia
Publicado 2016

Side Chain-Modified Benzothiazinone Derivatives with Anti-Mycobacterial Activity

por Fan, Dongguang, Wang, Bin, Stelitano, Giovanni, Savková, Karin, Riabova, Olga, Shi, Rui, Wu, Xiaomei, Chiarelli, Laurent R., Mikušová, Katarína, Makarov, Vadim, Lu, Yu, Hong, Yuzhi, Qiao, Chunhua
Publicado 2023

Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design

por Mori, Matteo, Stelitano, Giovanni, Gelain, Arianna, Pini, Elena, Chiarelli, Laurent R., Sammartino, José C., Poli, Giulio, Tuccinardi, Tiziano, Beretta, Giangiacomo, Porta, Alessio, Bellinzoni, Marco, Villa, Stefania, Meneghetti, Fiorella
Publicado 2020

Synthesis and Assessment of the In Vitro and Ex Vivo Activity of Salicylate Synthase (Mbti) Inhibitors as New Candidates for the Treatment of Mycobacterial Infections

por Mori, Matteo, Stelitano, Giovanni, Griego, Anna, Chiarelli, Laurent R., Cazzaniga, Giulia, Gelain, Arianna, Pini, Elena, Camera, Marina, Canzano, Paola, Fumagalli, Andrea, Scarpa, Edoardo, Cordiglieri, Chiara, Rizzello, Loris, Villa, Stefania, Meneghetti, Fiorella
Publicado 2022

A New Benzothiazolthiazolidine Derivative, 11726172, Is Active In Vitro, In Vivo, and against Nonreplicating Cells of Mycobacterium tuberculosis

por Salina, Elena G., Postiglione, Umberto, Chiarelli, Laurent R., Recchia, Deborah, Záhorszká, Monika, Lepioshkin, Alexander, Monakhova, Natalia, Pál, Adrian, Porta, Alessio, Zanoni, Giuseppe, Korduláková, Jana, Kazakova, Elena, Sassera, Davide, Pasca, Maria Rosalia, Makarov, Vadim, Degiacomi, Giulia
Publicado 2022

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

por Chiarelli, Laurent R., Mori, Matteo, Beretta, Giangiacomo, Gelain, Arianna, Pini, Elena, Sammartino, Josè Camilla, Stelitano, Giovanni, Barlocco, Daniela, Costantino, Luca, Lapillo, Margherita, Poli, Giulio, Caligiuri, Isabella, Rizzolio, Flavio, Bellinzoni, Marco, Tuccinardi, Tiziano, Villa, Stefania, Meneghetti, Fiorella
Publicado 2019