Exploring Weak Ligand–Protein Interactions by Long-Lived NMR States: Improved Contrast in Fragment-Based Drug Screening**

por Buratto, Roberto, Mammoli, Daniele, Chiarparin, Elisabetta, Williams, Glyn, Bodenhausen, Geoffrey
Publicado 2014

Nuclear magnetic resonance free ligand conformations and atomic resolution dynamics

por Balazs, Amber Y. S., Davies, Nichola L., Longmire, David, Packer, Martin J., Chiarparin, Elisabetta
Publicado 2021

In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

por Bertarello, Andrea, Berruyer, Pierrick, Artelsmair, Markus, Elmore, Charles S., Heydarkhan-Hagvall, Sepideh, Schade, Markus, Chiarparin, Elisabetta, Schantz, Staffan, Emsley, Lyndon
Publicado 2022

Relating Conformational Equilibria to Conformer‐Specific Lipophilicities: New Opportunities in Drug Discovery

por Linclau, Bruno, Wang, Zhong, Jeffries, Benjamin, Graton, Jérôme, Carbajo, Rodrigo J., Sinnaeve, Davy, Le Questel, Jean‐Yves, Scott, James S., Chiarparin, Elisabetta
Publicado 2021

Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines

por Linnane, Emily, Davey, Paul, Zhang, Pei, Puri, Sanyogitta, Edbrooke, Mark, Chiarparin, Elisabetta, Revenko, Alexey S, Macleod, A Robert, Norman, Jim C, Ross, Sarah J
Publicado 2019

Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups

por Jeffries, Benjamin, Wang, Zhong, Troup, Robert I, Goupille, Anaïs, Le Questel, Jean-Yves, Fallan, Charlene, Scott, James S, Chiarparin, Elisabetta, Graton, Jérôme, Linclau, Bruno
Publicado 2020

Design of rigid protein–protein interaction inhibitors enables targeting of undruggable Mcl-1

por Hargreaves, David, Carbajo, Rodrigo J., Bodnarchuk, Michael S., Embrey, Kevin, Rawlins, Philip B., Packer, Martin, Degorce, Sébastien L., Hird, Alexander W., Johannes, Jeffrey W., Chiarparin, Elisabetta, Schade, Markus
Publicado 2023

Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119

por Cromm, Philipp M., Adihou, Hélène, Kapoor, Shobhna, Vazquez‐Chantada, Mercedes, Davey, Paul, Longmire, David, Hennes, Elisabeth, Hofer, Walter, Küchler, Philipp, Chiarparin, Elisabetta, Waldmann, Herbert, Grossmann, Tom N.
Publicado 2019

Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling

por Wendt, Mathias, Bellavita, Rosa, Gerber, Alan, Efrém, Nina‐Louisa, van Ramshorst, Thirza, Pearce, Nicholas M., Davey, Paul R. J., Everard, Isabel, Vazquez‐Chantada, Mercedes, Chiarparin, Elisabetta, Grieco, Paolo, Hennig, Sven, Grossmann, Tom N.
Publicado 2021

Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling

por Kapustin, Alexander N., Davey, Paul, Longmire, David, Matthews, Carl, Linnane, Emily, Rustogi, Nitin, Stavrou, Maria, Devine, Paul W. A., Bond, Nicholas J., Hanson, Lyndsey, Sonzini, Silvia, Revenko, Alexey, MacLeod, A. Robert, Ross, Sarah, Chiarparin, Elisabetta, Puri, Sanyogitta
Publicado 2021

A protein tertiary structure mimetic modulator of the Hippo signalling pathway

por Adihou, Hélène, Gopalakrishnan, Ranganath, Förster, Tim, Guéret, Stéphanie M., Gasper, Raphael, Geschwindner, Stefan, Carrillo García, Carmen, Karatas, Hacer, Pobbati, Ajaybabu V., Vazquez‐Chantada, Mercedes, Davey, Paul, Wassvik, Carola M., Pang, Jeremy Kah Sheng, Soh, Boon Seng, Hong, Wanjin, Chiarparin, Elisabetta, Schade, Dennis, Plowright, Alleyn T., Valeur, Eric, Lemurell, Malin, Grossmann, Tom N., Waldmann, Herbert
Publicado 2020

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

por Tron, Adriana E., Belmonte, Matthew A., Adam, Ammar, Aquila, Brian M., Boise, Lawrence H., Chiarparin, Elisabetta, Cidado, Justin, Embrey, Kevin J., Gangl, Eric, Gibbons, Francis D., Gregory, Gareth P., Hargreaves, David, Hendricks, J. Adam, Johannes, Jeffrey W., Johnstone, Ricky W., Kazmirski, Steven L., Kettle, Jason G., Lamb, Michelle L., Matulis, Shannon M., Nooka, Ajay K., Packer, Martin J., Peng, Bo, Rawlins, Philip B., Robbins, Daniel W., Schuller, Alwin G., Su, Nancy, Yang, Wenzhan, Ye, Qing, Zheng, Xiaolan, Secrist, J. Paul, Clark, Edwin A., Wilson, David M., Fawell, Stephen E., Hird, Alexander W.
Publicado 2018