918. Identification of novel druggable host targets for Middle East respiratory syndrome coronavirus using a quantitative phosphoproteomics approach

por Chan, Jasper F W, Hu, Bingjie, Chik, Kenn K H, Yuan, Shuofeng, Chu, Hin
Publicado 2023

1899. The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro

por Chan, Jasper, Tsang, Jessica, Zou, Zijiao, Chik, Kenn, Yuan, Shuofeng, Chu, Hin, Lau, Susanna, Yuen, Kwok-Yung
Publicado 2018

Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant

por Xia, Shuai, Chan, Jasper Fuk-Woo, Wang, Lijue, Jiao, Fanke, Chik, Kenn Ka-Heng, Chu, Hin, Lan, Qiaoshuai, Xu, Wei, Wang, Qian, Wang, Chao, Yuen, Kwok-Yung, Lu, Lu, Jiang, Shibo
Publicado 2022

A pan-sarbecovirus vaccine induces highly potent and durable neutralizing antibody responses in non-human primates against SARS-CoV-2 Omicron variant

por Liu, Zezhong, Chan, Jasper Fuk-Woo, Zhou, Jie, Wang, Meiyu, Wang, Qian, Zhang, Guangxu, Xu, Wei, Chik, Kenn Ka-Heng, Zhang, Yilong, Wang, Youchun, Yuen, Kwok-Yung, Lu, Lu, Jiang, Shibo
Publicado 2022

hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs

por Zhang, Xi, Chu, Hin, Chik, Kenn Ka-Heng, Wen, Lei, Shuai, Huiping, Yang, Dong, Wang, Yixin, Hou, Yuxin, Yuen, Terrence Tsz-Tai, Cai, Jian-Piao, Yuan, Shuofeng, Yin, Feifei, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Publicado 2022

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells

por Zou, Zijiao, Tsang, Jessica Oi-Ling, Yan, Bingpeng, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cao, Jianli, Liang, Ronghui, Tang, Kaiming, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Chan, Jasper Fuk-Woo, Yuan, Shuofeng, Yuen, Kwok-Yung
Publicado 2020

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy

por Zhu, Zheng, Chu, Hin, Wen, Lei, Yuan, Shuofeng, Chik, Kenn Ka-Heng, Yuen, Terrence Tsz-Tai, Yip, Cyril Chik-Yan, Wang, Dong, Zhou, Jie, Yin, Feifei, Jin, Dong-Yan, Kok, Kin-Hang, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Publicado 2019

Vemurafenib Inhibits Enterovirus A71 Genome Replication and Virus Assembly

por Hu, Bodan, Chik, Kenn Ka-Heng, Chan, Jasper Fuk-Woo, Cai, Jian-Piao, Cao, Hehe, Tsang, Jessica Oi-Ling, Zou, Zijiao, Hung, Yin-Po, Tang, Kaiming, Jia, Lilong, Luo, Cuiting, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Yeung, Man-Lung, Yuan, Shuofeng
Publicado 2022

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targe...

por Chan, Jasper Fuk-Woo, Zhu, Zheng, Chu, Hin, Yuan, Shuofeng, Chik, Kenn Ka-Heng, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Yip, Cyril Chik-Yan, Zhang, Xi, Tsang, Jessica Oi-Ling, Zou, Zijiao, Tee, Kah-Meng, Shuai, Huiping, Lu, Gang, Yuen, Kwok-Yung
Publicado 2018

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

por Yuan, Shuofeng, Chan, Jasper F.W., Chik, Kenn K.H., Chan, Chris C.Y., Tsang, Jessica O.L., Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Chen, Lin-Lei, Wen, Kun, Cai, Jian-Piao, Ye, Zi-Wei, Lu, Gang, Chu, Hin, Jin, Dong-Yan, Yuen, Kwok-Yung
Publicado 2020

Severe fever with thrombocytopenia syndrome virus (SFTSV)-host interactome screen identifies viral nucleoprotein-associated host factors as potential antiviral targets

por Cao, Jianli, Lu, Gang, Wen, Lei, Luo, Peng, Huang, Yaoqiang, Liang, Ronghui, Tang, Kaiming, Qin, Zhenzhi, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Du, Jiang, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo, Yuan, Shuofeng
Publicado 2021

P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation

por Liu, Ming, Lu, Bingtai, Li, Yue, Yuan, Shuofeng, Zhuang, Zhen, Li, Guangyu, Wang, Dong, Ma, Liuheyi, Zhu, Jianheng, Zhao, Jinglu, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Chik, Kenn Ka-Heng, Zhao, Zhiyao, Xian, Huifang, Zhao, Jingxian, Zhao, Jincun, Chan, Jasper Fuk-Woo, Zhang, Yuxia
Publicado 2023

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

por Yuan, Shuofeng, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Wen, Lei, Tsang, Terance Gi-Wai, Cao, Jianli, Huang, Jingjing, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Choi, Garnet Kwan-Yue, Cai, Jian-Piao, Yin, Feifei, Chu, Hin, Liang, Mifang, Jin, Dong-Yan, Yuen, Kwok-Yung
Publicado 2019

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

por Yuan, Shuofeng, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Cai, Jian-Piao, Ye, Zi-Wei, Yin, Feifei, To, Kelvin Kai-Wang, Chu, Hin, Jin, Dong-Yan, Hung, Ivan Fan-Ngai, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Publicado 2020

In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor

por Wen, Lei, Tang, Kaiming, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Tsang, Jessica Oi-Ling, Liang, Ronghui, Cao, Jianli, Huang, Yaoqiang, Luo, Cuiting, Cai, Jian-Piao, Ye, Zi-Wei, Yin, Feifei, Chu, Hin, Jin, Dong-Yan, Yuen, Kwok-Yung, Yuan, Shuofeng, Chan, Jasper Fuk-Woo
Publicado 2021

Antibody evasion properties of SARS-CoV-2 Omicron sublineages

por Iketani, Sho, Liu, Lihong, Guo, Yicheng, Liu, Liyuan, Chan, Jasper F.-W., Huang, Yiming, Wang, Maple, Luo, Yang, Yu, Jian, Chu, Hin, Chik, Kenn K.-H., Yuen, Terrence T.-T., Yin, Michael T., Sobieszczyk, Magdalena E., Huang, Yaoxing, Yuen, Kwok-Yung, Wang, Harris H., Sheng, Zizhang, Ho, David D.
Publicado 2022

STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells

por Yang, Dong, Chu, Hin, Lu, Gang, Shuai, Huiping, Wang, Yixin, Hou, Yuxin, Zhang, Xi, Huang, Xiner, Hu, Bingjie, Chai, Yue, Yuen, Terrence Tsz-Tai, Zhao, Xiaoyu, Lee, Andrew Chak-Yiu, Ye, Ziwei, Li, Cun, Chik, Kenn Ka-Heng, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, Chan, Jasper Fuk-Woo
Publicado 2021

In Silico Structure-Based Design of Antiviral Peptides Targeting the Severe Fever with Thrombocytopenia Syndrome Virus Glycoprotein Gn

por Yuan, Shuo-Feng, Wen, Lei, Chik, Kenn Ka-Heng, Du, Jiang, Ye, Zi-Wei, Cao, Jian-Li, Tang, Kai-Ming, Liang, Rong-Hui, Cai, Jian-Piao, Luo, Cui-Ting, Yin, Fei-Fei, Lu, Gang, Chu, Hin, Liang, Mi-Fang, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Publicado 2021

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

por Qiao, Wei, Lau, Hui En, Xie, Huizhi, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Chu, Hin, Yuan, Shuofeng, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Yuen, Kwok-Yung, Cheung, Kenneth Man-Chee, Chan, Jasper Fuk-Woo, Yeung, Kelvin Wai-Kwok
Publicado 2022

Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

por Qiao, Wei, Lau, Hui En, Xie, Huizhi, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Chu, Hin, Yuan, Shuofeng, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Yuen, Kwok-Yung, Cheung, Kenneth Man-Chee, Chan, Jasper Fuk-Woo, Yeung, Kelvin Wai-Kwok
Publicado 2022