Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant

por Xia, Shuai, Chan, Jasper Fuk-Woo, Wang, Lijue, Jiao, Fanke, Chik, Kenn Ka-Heng, Chu, Hin, Lan, Qiaoshuai, Xu, Wei, Wang, Qian, Wang, Chao, Yuen, Kwok-Yung, Lu, Lu, Jiang, Shibo
Publicado 2022

A pan-sarbecovirus vaccine induces highly potent and durable neutralizing antibody responses in non-human primates against SARS-CoV-2 Omicron variant

por Liu, Zezhong, Chan, Jasper Fuk-Woo, Zhou, Jie, Wang, Meiyu, Wang, Qian, Zhang, Guangxu, Xu, Wei, Chik, Kenn Ka-Heng, Zhang, Yilong, Wang, Youchun, Yuen, Kwok-Yung, Lu, Lu, Jiang, Shibo
Publicado 2022

hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs

por Zhang, Xi, Chu, Hin, Chik, Kenn Ka-Heng, Wen, Lei, Shuai, Huiping, Yang, Dong, Wang, Yixin, Hou, Yuxin, Yuen, Terrence Tsz-Tai, Cai, Jian-Piao, Yuan, Shuofeng, Yin, Feifei, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Publicado 2022

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells

por Zou, Zijiao, Tsang, Jessica Oi-Ling, Yan, Bingpeng, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cao, Jianli, Liang, Ronghui, Tang, Kaiming, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Chan, Jasper Fuk-Woo, Yuan, Shuofeng, Yuen, Kwok-Yung
Publicado 2020

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy

por Zhu, Zheng, Chu, Hin, Wen, Lei, Yuan, Shuofeng, Chik, Kenn Ka-Heng, Yuen, Terrence Tsz-Tai, Yip, Cyril Chik-Yan, Wang, Dong, Zhou, Jie, Yin, Feifei, Jin, Dong-Yan, Kok, Kin-Hang, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Publicado 2019

Vemurafenib Inhibits Enterovirus A71 Genome Replication and Virus Assembly

por Hu, Bodan, Chik, Kenn Ka-Heng, Chan, Jasper Fuk-Woo, Cai, Jian-Piao, Cao, Hehe, Tsang, Jessica Oi-Ling, Zou, Zijiao, Hung, Yin-Po, Tang, Kaiming, Jia, Lilong, Luo, Cuiting, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Yeung, Man-Lung, Yuan, Shuofeng
Publicado 2022

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targe...

por Chan, Jasper Fuk-Woo, Zhu, Zheng, Chu, Hin, Yuan, Shuofeng, Chik, Kenn Ka-Heng, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Yip, Cyril Chik-Yan, Zhang, Xi, Tsang, Jessica Oi-Ling, Zou, Zijiao, Tee, Kah-Meng, Shuai, Huiping, Lu, Gang, Yuen, Kwok-Yung
Publicado 2018

Severe fever with thrombocytopenia syndrome virus (SFTSV)-host interactome screen identifies viral nucleoprotein-associated host factors as potential antiviral targets

por Cao, Jianli, Lu, Gang, Wen, Lei, Luo, Peng, Huang, Yaoqiang, Liang, Ronghui, Tang, Kaiming, Qin, Zhenzhi, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Du, Jiang, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo, Yuan, Shuofeng
Publicado 2021

P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation

por Liu, Ming, Lu, Bingtai, Li, Yue, Yuan, Shuofeng, Zhuang, Zhen, Li, Guangyu, Wang, Dong, Ma, Liuheyi, Zhu, Jianheng, Zhao, Jinglu, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Chik, Kenn Ka-Heng, Zhao, Zhiyao, Xian, Huifang, Zhao, Jingxian, Zhao, Jincun, Chan, Jasper Fuk-Woo, Zhang, Yuxia
Publicado 2023

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

por Yuan, Shuofeng, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Wen, Lei, Tsang, Terance Gi-Wai, Cao, Jianli, Huang, Jingjing, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Choi, Garnet Kwan-Yue, Cai, Jian-Piao, Yin, Feifei, Chu, Hin, Liang, Mifang, Jin, Dong-Yan, Yuen, Kwok-Yung
Publicado 2019

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

por Yuan, Shuofeng, Chan, Chris Chun-Yiu, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Liang, Ronghui, Cao, Jianli, Tang, Kaiming, Cai, Jian-Piao, Ye, Zi-Wei, Yin, Feifei, To, Kelvin Kai-Wang, Chu, Hin, Jin, Dong-Yan, Hung, Ivan Fan-Ngai, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Publicado 2020

In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor

por Wen, Lei, Tang, Kaiming, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Tsang, Jessica Oi-Ling, Liang, Ronghui, Cao, Jianli, Huang, Yaoqiang, Luo, Cuiting, Cai, Jian-Piao, Ye, Zi-Wei, Yin, Feifei, Chu, Hin, Jin, Dong-Yan, Yuen, Kwok-Yung, Yuan, Shuofeng, Chan, Jasper Fuk-Woo
Publicado 2021

STAT2-dependent restriction of Zika virus by human macrophages but not dendritic cells

por Yang, Dong, Chu, Hin, Lu, Gang, Shuai, Huiping, Wang, Yixin, Hou, Yuxin, Zhang, Xi, Huang, Xiner, Hu, Bingjie, Chai, Yue, Yuen, Terrence Tsz-Tai, Zhao, Xiaoyu, Lee, Andrew Chak-Yiu, Ye, Ziwei, Li, Cun, Chik, Kenn Ka-Heng, Zhang, Anna Jinxia, Zhou, Jie, Yuan, Shuofeng, Chan, Jasper Fuk-Woo
Publicado 2021

In Silico Structure-Based Design of Antiviral Peptides Targeting the Severe Fever with Thrombocytopenia Syndrome Virus Glycoprotein Gn

por Yuan, Shuo-Feng, Wen, Lei, Chik, Kenn Ka-Heng, Du, Jiang, Ye, Zi-Wei, Cao, Jian-Li, Tang, Kai-Ming, Liang, Rong-Hui, Cai, Jian-Piao, Luo, Cui-Ting, Yin, Fei-Fei, Lu, Gang, Chu, Hin, Liang, Mi-Fang, Jin, Dong-Yan, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo
Publicado 2021

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

por Qiao, Wei, Lau, Hui En, Xie, Huizhi, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Chu, Hin, Yuan, Shuofeng, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Yuen, Kwok-Yung, Cheung, Kenneth Man-Chee, Chan, Jasper Fuk-Woo, Yeung, Kelvin Wai-Kwok
Publicado 2022

Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

por Qiao, Wei, Lau, Hui En, Xie, Huizhi, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Chu, Hin, Yuan, Shuofeng, Yuen, Terrence Tsz-Tai, Chik, Kenn Ka-Heng, Tsang, Jessica Oi-Ling, Chan, Chris Chun-Yiu, Cai, Jian-Piao, Luo, Cuiting, Yuen, Kwok-Yung, Cheung, Kenneth Man-Chee, Chan, Jasper Fuk-Woo, Yeung, Kelvin Wai-Kwok
Publicado 2022

The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage

por Liang, Ronghui, Ye, Zi-Wei, Ong, Chon Phin, Qin, Zhenzhi, Xie, Yubin, Fan, Yilan, Tang, Kaiming, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Yang, Xiaomeng, Cao, Hehe, Wang, Kun, Sun, Haoran, Hu, Bodan, Cai, Jian-Piao, Luo, Cuiting, Chik, Kenn Ka-Heng, Chu, Hin, Zheng, Yi, Yuen, Kwok-Yung, Chan, Jasper Fuk-Woo, Jin, Dong-Yan, Yuan, Shuofeng
Publicado 2022

Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs

por Chan, Jasper Fuk-Woo, Yip, Cyril Chik-Yan, Tsang, Jessica Oi-Ling, Tee, Kah-Meng, Cai, Jian-Piao, Chik, Kenn Ka-Heng, Zhu, Zheng, Chan, Chris Chung-Sing, Choi, Garnet Kwan-Yue, Sridhar, Siddharth, Zhang, Anna Jinxia, Lu, Gang, Chiu, Kin, Lo, Amy Cheuk-Yin, Tsao, Sai-Wah, Kok, Kin-Hang, Jin, Dong-Yan, Chan, Kwok-Hung, Yuen, Kwok-Yung
Publicado 2016

Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant...

por Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Chan, Chris Chung-Sing, Yip, Cyril Chik-Yan, Mak, Winger Wing-Nga, Zhu, Houshun, Poon, Vincent Kwok-Man, Tee, Kah-Meng, Zhu, Zheng, Cai, Jian-Piao, Tsang, Jessica Oi-Ling, Chik, Kenn Ka-Heng, Yin, Feifei, Chan, Kwok-Hung, Kok, Kin-Hang, Jin, Dong-Yan, Au-Yeung, Rex Kwok-Him, Yuen, Kwok-Yung
Publicado 2016

A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamsters

por Zhang, Bao-Zhong, Wang, Xiaolei, Yuan, Shuofeng, Li, Wenjun, Dou, Ying, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Cai, Jian-Piao, Chik, Kenn KaHeng, Tang, Kaiming, Chan, Chris Chun-Yiu, Hu, Ye-Fan, Hu, Jing-Chu, Badea, Smaranda Ruxandra, Gong, Hua-Rui, Lin, Xuansheng, Chu, Hin, Li, Xuechen, To, Kelvin Kai-Wang, Liu, Li, Chen, Zhiwei, Hung, Ivan Fan-Ngai, Yuen, Kwok Yung, Chan, Jasper Fuk-Woo, Huang, Jian-Dong
Publicado 2021