Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy

por Reif, Andreas, Chiki, Anass, Ricci, Jonathan, Lashuel, Hilal A.
Publicado 2018

A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving exper...

por Kumar, Senthil T., Donzelli, Sonia, Chiki, Anass, Syed, Muhammed Muazzam Kamil, Lashuel, Hilal A.
Publicado 2020

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau

por Ait-Bouziad, Nadine, Chiki, Anass, Limorenko, Galina, Xiao, Shifeng, Eliezer, David, Lashuel, Hilal A.
Publicado 2020

Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases

por Chiki, Anass, Ricci, Jonathan, Hegde, Ramanath, Abriata, Luciano A., Reif, Andreas, Boudeffa, Driss, Lashuel, Hilal A.
Publicado 2020

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

por DeGuire, Sean M., Ruggeri, Francesco S., Fares, Mohamed-Bilal, Chiki, Anass, Cendrowska, Urszula, Dietler, Giovanni, Lashuel, Hilal A.
Publicado 2018

Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation

por Chiki, Anass, Zhang, Zhidian, Rajasekhar, Kolla, Abriata, Luciano A., Rostami, Iman, Krapp, Lucien F., Boudeffa, Driss, Dal Peraro, Matteo, Lashuel, Hilal A.
Publicado 2021

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity

por Stephens, Amberley D., Zacharopoulou, Maria, Moons, Rani, Fusco, Giuliana, Seetaloo, Neeleema, Chiki, Anass, Woodhams, Philippa J., Mela, Ioanna, Lashuel, Hilal A., Phillips, Jonathan J., De Simone, Alfonso, Sobott, Frank, Schierle, Gabriele S. Kaminski
Publicado 2020

Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM

por Cendrowska, Urszula, Silva, Paulo Jacob, Ait-Bouziad, Nadine, Müller, Marie, Guven, Zekiye Pelin, Vieweg, Sophie, Chiki, Anass, Radamaker, Lynn, Kumar, Senthil T., Fändrich, Marcus, Tavanti, Francesco, Menziani, Maria Cristina, Alexander-Katz, Alfredo, Stellacci, Francesco, Lashuel, Hilal A.
Publicado 2020

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

por Cariulo, Cristina, Azzollini, Lucia, Verani, Margherita, Martufi, Paola, Boggio, Roberto, Chiki, Anass, Deguire, Sean M., Cherubini, Marta, Gines, Silvia, Marsh, J. Lawrence, Conforti, Paola, Cattaneo, Elena, Santimone, Iolanda, Squitieri, Ferdinando, Lashuel, Hilal A., Petricca, Lara, Caricasole, Andrea
Publicado 2017

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

por Hegde, Ramanath Narayana, Chiki, Anass, Petricca, Lara, Martufi, Paola, Arbez, Nicolas, Mouchiroud, Laurent, Auwerx, Johan, Landles, Christian, Bates, Gillian P, Singh‐Bains, Malvindar K, Dragunow, Mike, Curtis, Maurice A, Faull, Richard LM, Ross, Christopher A, Caricasole, Andrea, Lashuel, Hilal A
Publicado 2020

Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity

por Lashuel, Hilal A., Mahul-Mellier, Anne-Laure, Novello, Salvatore, Hegde, Ramanath Narayana, Jasiqi, Yllza, Altay, Melek Firat, Donzelli, Sonia, DeGuire, Sean M., Burai, Ritwik, Magalhães, Pedro, Chiki, Anass, Ricci, Jonathan, Boussouf, Manel, Sadek, Ahmed, Stoops, Erik, Iseli, Christian, Guex, Nicolas
Publicado 2022

Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates

por Herrmann, Frank, Hessmann, Manuela, Schaertl, Sabine, Berg-Rosseburg, Karola, Brown, Christopher J, Bursow, Galina, Chiki, Anass, Ebneth, Andreas, Gehrmann, Miriam, Hoeschen, Nicole, Hotze, Madlen, Jahn, Stefanie, Johnson, Peter D, Khetarpal, Vinod, Kiselyov, Alex, Kottig, Karsten, Ladewig, Stefanie, Lashuel, Hilal, Letschert, Sven, Mills, Matthew R, Petersen, Kathrin, Prime, Michael E, Scheich, Christoph, Schmiedel, Gerhard, Wityak, John, Liu, Longbin, Dominguez, Celia, Muñoz-Sanjuán, Ignacio, Bard, Jonathan A
Publicado 2021