Conformational dynamics of RNA G(4)C(2) and G(2)C(4) repeat expansions causing ALS/FTD using NMR and molecular dynamics studies

por Taghavi, Amirhossein, Baisden, Jared T, Childs-Disney, Jessica L, Yildirim, Ilyas, Disney, Matthew D
Publicado 2023

Improvement of RNA secondary structure prediction using RNase H cleavage and randomized oligonucleotides

por Kauffmann, Andrew D., Campagna, Ryan J., Bartels, Chantal B., Childs-Disney, Jessica L.
Publicado 2009

Targeting the r(CGG) Repeats That Cause FXTAS with Modularly Assembled Small Molecules and Oligonucleotides

por Tran, Tuan, Childs-Disney, Jessica L., Liu, Biao, Guan, Lirui, Rzuczek, Suzanne, Disney, Matthew D.
Publicado 2014

The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology

por Chen, Jonathan L., Moss, Walter N., Spencer, Adam, Zhang, Peiyuan, Childs-Disney, Jessica L., Disney, Matthew D.
Publicado 2019

Targeting RNA structures with small molecules

por Childs-Disney, Jessica L., Yang, Xueyi, Gibaut, Quentin M. R., Tong, Yuquan, Batey, Robert T., Disney, Matthew D.
Publicado 2022

Analysis of secondary structural elements in human microRNA hairpin precursors

por Liu, Biao, Childs-Disney, Jessica L., Znosko, Brent M., Wang, Dan, Fallahi, Mohammad, Gallo, Steven M., Disney, Matthew D.
Publicado 2016

RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression

por O’Leary, Collin A., Andrews, Ryan J., Tompkins, Van S., Chen, Jonathan L., Childs-Disney, Jessica L., Disney, Matthew D., Moss, Walter N.
Publicado 2019

Defining RNA–Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA

por Velagapudi, Sai Pradeep, Luo, Yiling, Tran, Tuan, Haniff, Hafeez S., Nakai, Yoshio, Fallahi, Mohammad, Martinez, Gustavo J., Childs-Disney, Jessica L., Disney, Matthew D.
Publicado 2017

Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)(exp) Degrader in Myotonic Dystrophy

por Gibaut, Quentin M. R., Bush, Jessica A., Tong, Yuquan, Baisden, Jared T., Taghavi, Amirhossein, Olafson, Hailey, Yao, Xiyuan, Childs-Disney, Jessica L., Wang, Eric T., Disney, Matthew D.
Publicado 2023

DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor

por Benhamou, Raphael I., Suresh, Blessy M., Tong, Yuquan, Cochrane, Wesley G., Cavett, Valerie, Vezina-Dawod, Simon, Abegg, Daniel, Childs-Disney, Jessica L., Adibekian, Alexander, Paegel, Brian M., Disney, Matthew D.
Publicado 2022

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

por Costales, Matthew G., Aikawa, Haruo, Li, Yue, Childs-Disney, Jessica L., Abegg, Daniel, Hoch, Dominic G., Pradeep Velagapudi, Sai, Nakai, Yoshio, Khan, Tanya, Wang, Kye Won, Yildirim, Ilyas, Adibekian, Alexander, Wang, Eric T., Disney, Matthew D.
Publicado 2020

Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA

por Zhang, Peiyuan, Park, Hye-Jin, Zhang, Jie, Junn, Eunsung, Andrews, Ryan J., Velagapudi, Sai Pradeep, Abegg, Daniel, Vishnu, Kamalakannan, Costales, Matthew G., Childs-Disney, Jessica L., Adibekian, Alexander, Moss, Walter N., Mouradian, M. Maral, Disney, Matthew D.
Publicado 2020

Induction and Reversal of Myotonic Dystrophy Type 1 Pre-mRNA Splicing Defects by Small Molecules

por Childs-Disney, Jessica L., Stepniak-Konieczna, Ewa, Tran, Tuan, Yildirim, Ilyas, Park, HaJeung, Chen, Catherine Z., Hoskins, Jason, Southall, Noel, Marugan, Juan J., Patnaik, Samarjit, Zheng, Wei, Austin, Chris P., Schatz, George C., Sobczak, Krzysztof, Thornton, Charles A., Disney, Matthew D.
Publicado 2013

A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G(4)C(2))(exp) in c9ALS/FTD via the nuclear RNA exosome

por Bush, Jessica A., Meyer, Samantha M., Fuerst, Rita, Tong, Yuquan, Li, Yue, Benhamou, Raphael I., Aikawa, Haruo, Zanon, Patrick R. A., Gibaut, Quentin M. R., Angelbello, Alicia J., Gendron, Tania F., Zhang, Yong-Jie, Petrucelli, Leonard, Heick Jensen, Torben, Childs-Disney, Jessica L., Disney, Matthew D.
Publicado 2022

Programming inactive RNA-binding small molecules into bioactive degraders

por Tong, Yuquan, Lee, Yeongju, Liu, Xiaohui, Childs-Disney, Jessica L., Suresh, Blessy M., Benhamou, Raphael I., Yang, Chunying, Li, Weimin, Costales, Matthew G., Haniff, Hafeez S., Sievers, Sonja, Abegg, Daniel, Wegner, Tristan, Paulisch, Tiffany O., Lekah, Elizabeth, Grefe, Maison, Crynen, Gogce, Van Meter, Montina, Wang, Tenghui, Gibaut, Quentin M. R., Cleveland, John L., Adibekian, Alexander, Glorius, Frank, Waldmann, Herbert, Disney, Matthew D.
Publicado 2023