The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases

por Hogan, Kelly A., Chini, Claudia C. S., Chini, Eduardo N.
Publicado 2019

DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα

por Chini, Claudia C. S., Escande, Carlos, Nin, Veronica, Chini, Eduardo N.
Publicado 2013

Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer

por Chini, Eduardo Nunes, Chini, Claudia C. S., Nin, Veronica, Escande, Carlos
Publicado 2013

Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype

por Escande, Carlos, Nin, Veronica, Pirtskhalava, Tamar, Chini, Claudia C.S., Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo N.
Publicado 2015

Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer

por Espindola-Netto, Jair Machado, Chini, Claudia C.S., Tarragó, Mariana, Wang, Enfeng, Dutta, Shamit, Pal, Krishnendu, Mukhopadhyay, Debabrata, Sola-Penna, Mauro, Chini, Eduardo N.
Publicado 2017

Deleted in Breast Cancer 1 regulates cellular senescence during obesity

por Escande, Carlos, Nin, Veronica, Pirtskhalava, Tamar, Chini, Claudia C, Thereza Barbosa, Maria, Mathison, Angela, Urrutia, Raul, Tchkonia, Tamar, Kirkland, James L, Chini, Eduardo N
Publicado 2014

Aging increases the risk of flap necrosis in murine models: A systematic review

por Garcia, John P., Avila, Francisco R., Torres-Guzman, Ricardo A., Maita, Karla C., Eldaly, Abdullah S., Palmieri, Luiza, Emam, Omar, Chini, Claudia C., Chini, Eduardo N., Forte, Antonio J.
Publicado 2022

Dihydronicotinamide Riboside Is a Potent NAD(+) Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages

por Chini, Claudia C. S., Peclat, Thais R., Gomez, Lilian S., Zeidler, Julianna D., Warner, Gina M., Kashyap, Sonu, Mazdeh, Delaram Z., Hayat, Faisal, Migaud, Marie E., Paulus, Aneel, Chanan-Khan, Asher A., Chini, Eduardo N.
Publicado 2022

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging

por Peclat, Thais R., Thompson, Katie L., Warner, Gina M., Chini, Claudia C.S., Tarragó, Mariana G., Mazdeh, Delaram Z., Zhang, Chunlian, Zavala‐Solorio, Jose, Kolumam, Ganesh, Liang Wong, Yao, Cohen, Robert L., Chini, Eduardo N.
Publicado 2022

Low NAD(+) Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice

por Meyer-Ficca, Mirella L., Zwerdling, Alexie E., Swanson, Corey A., Tucker, Abby G., Lopez, Sierra A., Wandersee, Miles K., Warner, Gina M., Thompson, Katie L., Chini, Claudia C.S., Chen, Haolin, Chini, Eduardo N., Meyer, Ralph G.
Publicado 2022

A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo

por Santos, Leonardo, Colman, Laura, Contreras, Paola, Chini, Claudia C., Carlomagno, Adriana, Leyva, Alejandro, Bresque, Mariana, Marmisolle, Inés, Quijano, Celia, Durán, Rosario, Irigoín, Florencia, Prieto-Echagüe, Victoria, Vendelbo, Mikkel H., Sotelo-Silveira, José R., Chini, Eduardo N., Badano, Jose L., Calliari, Aldo J., Escande, Carlos
Publicado 2019

Targeting CD38-dependent NAD(+) metabolism to mitigate multiple organ fibrosis

por Shi, Bo, Wang, Wenxia, Korman, Benjamin, Kai, Li, Wang, Qianqian, Wei, Jun, Bale, Swarna, Marangoni, Roberta Goncalves, Bhattacharyya, Swati, Miller, Stephen, Xu, Dan, Akbarpour, Mahzad, Cheresh, Paul, Proccissi, Daniele, Gursel, Demirkan, Espindola-Netto, Jair Machado, Chini, Claudia C.S., de Oliveira, Guilherme C., Gudjonsson, Johann E., Chini, Eduardo N., Varga, John
Publicado 2020

Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)

por Zeidler, Julianna D., Chini, Claudia C.S., Kanamori, Karina S., Kashyap, Sonu, Espindola-Netto, Jair M., Thompson, Katie, Warner, Gina, Cabral, Fernanda S., Peclat, Thais R., Gomez, Lilian Sales, Lopez, Sierra A., Wandersee, Miles K., Schoon, Renee A., Reid, Kimberly, Menzies, Keir, Beckedorff, Felipe, Reid, Joel M., Brachs, Sebastian, Meyer, Ralph G., Meyer-Ficca, Mirella L., Chini, Eduardo Nunes
Publicado 2022

CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype

por de Zélicourt, Antoine, Fayssoil, Abdallah, Dakouane‐Giudicelli, Mbarka, De Jesus, Isley, Karoui, Ahmed, Zarrouki, Faouzi, Lefebvre, Florence, Mansart, Arnaud, Launay, Jean‐Marie, Piquereau, Jerome, Tarragó, Mariana G, Bonay, Marcel, Forand, Anne, Moog, Sophie, Piétri‐Rouxel, France, Brisebard, Elise, Chini, Claudia C S, Kashyap, Sonu, Fogarty, Matthew J, Sieck, Gary C, Mericskay, Mathias, Chini, Eduardo N, Gomez, Ana Maria, Cancela, José‐Manuel, de la Porte, Sabine
Publicado 2022

CD38 ecto-enzyme in immune cells is induced during aging regulating NAD(+) and NMN levels

por Chini, Claudia C.S., Peclat, Thais R., Warner, Gina M., Kashyap, Sonu, Espindola-Netto, Jair Machado, de Oliveira, Guilherme C., Gomez, Lilian S., Hogan, Kelly A., Tarragó, Mariana G., Puranik, Amrutesh S., Agorrody, Guillermo, Thompson, Katie L., Dang, Kevin, Clarke, Starlynn, Childs, Bennett G., Kanamori, Karina S., Witte, Micaela A., Vidal, Paola, Kirkland, Anna L., De Cecco, Marco, Chellappa, Karthikeyani, McReynolds, Melanie R., Jankowski, Connor, Tchkonia, Tamara, Kirkland, James L., Sedivy, John M., van Deursen, Jan M., Baker, Darren J., van Schooten, Wim, Rabinowitz, Joshua D., Baur, Joseph A., Chini, Eduardo N.
Publicado 2020