The Multi-faceted Ecto-enzyme CD38: Roles in Immunomodulation, Cancer, Aging, and Metabolic Diseases

por Hogan, Kelly A., Chini, Claudia C. S., Chini, Eduardo N.
Publicado 2019

DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα

por Chini, Claudia C. S., Escande, Carlos, Nin, Veronica, Chini, Eduardo N.
Publicado 2013

Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype

por Escande, Carlos, Nin, Veronica, Pirtskhalava, Tamar, Chini, Claudia C.S., Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo N.
Publicado 2015

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

por Palmer, Allyson K., Tchkonia, Tamara, LeBrasseur, Nathan K., Chini, Eduardo N., Xu, Ming, Kirkland, James L.
Publicado 2015

SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice

por Tulino, Raffaella, Benjamin, Agnesska C., Jolinon, Nelly, Smith, Donna L., Chini, Eduardo N., Carnemolla, Alisia, Bates, Gillian P.
Publicado 2016

Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice

por Tulino, Raffaella, Benjamin, Agnesska C., Jolinon, Nelly, Smith, Donna L., Chini, Eduardo N., Carnemolla, Alisia, Bates, Gillian P.
Publicado 2016

Endurance Capacity, Not Body Size, Determines Physical Activity Levels: Role of Skeletal Muscle PEPCK

por Novak, Colleen M., Escande, Carlos, Gerber, Susan M., Chini, Eduardo N., Zhang, Minzhi, Britton, Steven L., Koch, Lauren G., Levine, James A.
Publicado 2009

Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer

por Espindola-Netto, Jair Machado, Chini, Claudia C.S., Tarragó, Mariana, Wang, Enfeng, Dutta, Shamit, Pal, Krishnendu, Mukhopadhyay, Debabrata, Sola-Penna, Mauro, Chini, Eduardo N.
Publicado 2017

Deleted in Breast Cancer 1 regulates cellular senescence during obesity

por Escande, Carlos, Nin, Veronica, Pirtskhalava, Tamar, Chini, Claudia C, Thereza Barbosa, Maria, Mathison, Angela, Urrutia, Raul, Tchkonia, Tamar, Kirkland, James L, Chini, Eduardo N
Publicado 2014

Flavonoid Apigenin Is an Inhibitor of the NAD(+)ase CD38: Implications for Cellular NAD(+) Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

por Escande, Carlos, Nin, Veronica, Price, Nathan L., Capellini, Verena, Gomes, Ana P., Barbosa, Maria Thereza, O’Neil, Luke, White, Thomas A., Sinclair, David A., Chini, Eduardo N.
Publicado 2013

Krüppel-like Factor 11 Regulates the Expression of Metabolic Genes via an Evolutionarily Conserved Protein Interaction Domain Functionally Disrupted in Maturity Onset Diabetes of t...

por Lomberk, Gwen, Grzenda, Adrienne, Mathison, Angela, Escande, Carlos, Zhang, Jin-San, Calvo, Ezequiel, Miller, Laurence J., Iovanna, Juan, Chini, Eduardo N., Fernandez-Zapico, Martin E., Urrutia, Raul
Publicado 2013

Aging increases the risk of flap necrosis in murine models: A systematic review

por Garcia, John P., Avila, Francisco R., Torres-Guzman, Ricardo A., Maita, Karla C., Eldaly, Abdullah S., Palmieri, Luiza, Emam, Omar, Chini, Claudia C., Chini, Eduardo N., Forte, Antonio J.
Publicado 2022

Senescent Cells Accumulate in Systemic Sclerosis Skin

por Shi, Bo, Tsou, Pei-Suen, Ma, Feiyang, Mariani, Michael P., Mattichak, Megan N., LeBrasseur, Nathan K., Chini, Eduardo N., Lafyatis, Robert, Khanna, Dinesh, Whitfield, Michael L., Gudjonsson, Johann E., Varga, John
Publicado 2023

Dihydronicotinamide Riboside Is a Potent NAD(+) Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages

por Chini, Claudia C. S., Peclat, Thais R., Gomez, Lilian S., Zeidler, Julianna D., Warner, Gina M., Kashyap, Sonu, Mazdeh, Delaram Z., Hayat, Faisal, Migaud, Marie E., Paulus, Aneel, Chanan-Khan, Asher A., Chini, Eduardo N.
Publicado 2022

A stress-induced cilium-to-PML-NB route drives senescence initiation

por Ma, Xiaoyu, Zhang, Yingyi, Zhang, Yuanyuan, Zhang, Xu, Huang, Yan, He, Kai, Chen, Chuan, Hao, Jielu, Zhao, Debiao, LeBrasseur, Nathan K., Kirkland, James L., Chini, Eduardo N., Wei, Qing, Ling, Kun, Hu, Jinghua
Publicado 2023

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging

por Peclat, Thais R., Thompson, Katie L., Warner, Gina M., Chini, Claudia C.S., Tarragó, Mariana G., Mazdeh, Delaram Z., Zhang, Chunlian, Zavala‐Solorio, Jose, Kolumam, Ganesh, Liang Wong, Yao, Cohen, Robert L., Chini, Eduardo N.
Publicado 2022

Low NAD(+) Levels Are Associated With a Decline of Spermatogenesis in Transgenic ANDY and Aging Mice

por Meyer-Ficca, Mirella L., Zwerdling, Alexie E., Swanson, Corey A., Tucker, Abby G., Lopez, Sierra A., Wandersee, Miles K., Warner, Gina M., Thompson, Katie L., Chini, Claudia C.S., Chen, Haolin, Chini, Eduardo N., Meyer, Ralph G.
Publicado 2022

FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue

por Zhang, Yingyi, Hao, Jielu, Tarrago, Mariana G., Warner, Gina M., Giorgadze, Nino, Wei, Qing, Huang, Yan, He, Kai, Chen, Chuan, Peclat, Thais R., White, Thomas A., Ling, Kun, Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo N., Hu, Jinghua
Publicado 2021

p21 induces a senescence program and skeletal muscle dysfunction

por Englund, Davis A., Jolliffe, Alyssa, Aversa, Zaira, Zhang, Xu, Sturmlechner, Ines, Sakamoto, Ayumi E., Zeidler, Julianna D., Warner, Gina M., McNinch, Colton, White, Thomas A., Chini, Eduardo N., Baker, Darren J., van Deursen, Jan M., LeBrasseur, Nathan K.
Publicado 2022

A novel form of Deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo

por Santos, Leonardo, Colman, Laura, Contreras, Paola, Chini, Claudia C., Carlomagno, Adriana, Leyva, Alejandro, Bresque, Mariana, Marmisolle, Inés, Quijano, Celia, Durán, Rosario, Irigoín, Florencia, Prieto-Echagüe, Victoria, Vendelbo, Mikkel H., Sotelo-Silveira, José R., Chini, Eduardo N., Badano, Jose L., Calliari, Aldo J., Escande, Carlos
Publicado 2019