Neuroprotective and Antioxidant Properties of CholesteroNitrone ChN2 and QuinolylNitrone QN23 in an Experimental Model of Cerebral Ischemia: Involvement of Necrotic and Apoptotic C...

por Chamorro, Beatriz, Izquierdo-Bermejo, Sara, Martín-de-Saavedra, María Dolores, López-Muñoz, Francisco, Chioua, Mourad, Marco-Contelles, José, Oset-Gasque, María Jesús
Publicado 2023

Homo-Tris-Nitrones Derived from α-Phenyl-N-tert-butylnitrone: Synthesis, Neuroprotection and Antioxidant Properties

por Diez-Iriepa, Daniel, Chamorro, Beatriz, Talaván, Marta, Chioua, Mourad, Iriepa, Isabel, Hadjipavlou-Litina, Dimitra, López-Muñoz, Francisco, Marco-Contelles, José, Oset-Gasque, María Jesús
Publicado 2020

Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations

por Fernández-Serra, Rocío, Martínez-Alonso, Emma, Alcázar, Alberto, Chioua, Mourad, Marco-Contelles, José, Martínez-Murillo, Ricardo, Ramos, Milagros, Guinea, Gustavo V., González-Nieto, Daniel
Publicado 2022

Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR ana...

por Bautista-Aguilera, Oscar M, Esteban, Gerard, Chioua, Mourad, Nikolic, Katarina, Agbaba, Danica, Moraleda, Ignacio, Iriepa, Isabel, Soriano, Elena, Samadi, Abdelouahid, Unzeta, Mercedes, Marco-Contelles, José
Publicado 2014

Imidazopyranotacrines as Non-Hepatotoxic, Selective Acetylcholinesterase Inhibitors, and Antioxidant Agents for Alzheimer′s Disease Therapy

por Boulebd, Houssem, Ismaili, Lhassane, Bartolini, Manuela, Bouraiou, Abdelmalek, Andrisano, Vincenza, Martin, Helene, Bonet, Alexandre, Moraleda, Ignacio, Iriepa, Isabel, Chioua, Mourad, Belfaitah, Ali, Marco-Contelles, José
Publicado 2016

Synthesis, Neuroprotection, and Antioxidant Activity of 1,1′-Biphenylnitrones as α-Phenyl-N-tert-butylnitrone Analogues in In Vitro Ischemia Models

por Chamorro, Beatriz, García-Vieira, David, Diez-Iriepa, Daniel, Garagarza, Estíbaliz, Chioua, Mourad, Hadjipavlou-Litina, Dimitra, López-Muñoz, Francisco, Marco-Contelles, José, Oset-Gasque, María Jesús
Publicado 2021

Neuroprotective and antioxidant properties of new quinolylnitrones in in vitro and in vivo cerebral ischemia models

por Chamorro, Beatriz, Izquierdo-Bermejo, Sara, Serrano, Julia, Hadjipavlou-Litina, Dimitra, Chioua, Mourad, López-Muñoz, Francisco, Marco-Contelles, José, Martínez-Murillo, Ricardo, Oset-Gasque, María Jesús
Publicado 2023

Characterization of a CholesteroNitrone (ISQ-201), a Novel Drug Candidate for the Treatment of Ischemic Stroke

por Martínez-Alonso, Emma, Escobar-Peso, Alejandro, Ayuso, Maria I., Gonzalo-Gobernado, Rafael, Chioua, Mourad, Montoya, Juan J., Montaner, Joan, Fernández, Israel, Marco-Contelles, José, Alcázar, Alberto
Publicado 2020

Privileged Quinolylnitrones for the Combined Therapy of Ischemic Stroke and Alzheimer’s Disease

por Alonso, José M., Escobar-Peso, Alejandro, Palomino-Antolín, Alejandra, Diez-Iriepa, Daniel, Chioua, Mourad, Martínez-Alonso, Emma, Iriepa, Isabel, Egea, Javier, Alcázar, Alberto, Marco-Contelles, José
Publicado 2021

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer’s Disease Therapy

por Ramos, Eva, Palomino-Antolín, Alejandra, Bartolini, Manuela, Iriepa, Isabel, Moraleda, Ignacio, Diez-Iriepa, Daniel, Samadi, Abdelouahid, Cortina, Carol V., Chioua, Mourad, Egea, Javier, Romero, Alejandro, Marco-Contelles, José
Publicado 2019

Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke

por Martínez-Alonso, Emma, Escobar-Peso, Alejandro, Aliena-Valero, Alicia, Torregrosa, Germán, Chioua, Mourad, Fernández-Serra, Rocío, González-Nieto, Daniel, Ouahid, Youness, Salom, Juan B., Masjuan, Jaime, Marco-Contelles, José, Alcázar, Alberto
Publicado 2022

Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer’s Disease

por Dgachi, Youssef, Bautista-Aguilera, Oscar M., Benchekroun, Mohamed, Martin, Hélène, Bonet, Alexandre, Knez, Damijan, Godyń, Justyna, Malawska, Barbara, Gobec, Stanislav, Chioua, Mourad, Janockova, Jana, Soukup, Ondrej, Chabchoub, Fakher, Marco-Contelles, José, Ismaili, Lhassane
Publicado 2016

Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy

por Bautista-Aguilera, Óscar M., Ismaili, Lhassane, Chioua, Mourad, Andrys, Rudolf, Schmidt, Monika, Bzonek, Petr, Martínez-Grau, María Ángeles, Beadle, Christopher D., Vetman, Tatiana, López-Muñoz, Francisco, Iriepa, Isabel, Refouvelet, Bernard, Musilek, Kamil, Marco-Contelles, José
Publicado 2020

Synthesis, antioxidant properties and neuroprotection of α-phenyl-tert-butylnitrone derived HomoBisNitrones in in vitro and in vivo ischemia models

por Chamorro, Beatriz, Diez-Iriepa, Daniel, Merás-Sáiz, Belén, Chioua, Mourad, García-Vieira, David, Iriepa, Isabel, Hadjipavlou-Litina, Dimitra, López-Muñoz, Francisco, Martínez-Murillo, Ricardo, Gonzàlez-Nieto, Daniel, Fernández, Israel, Marco-Contelles, José, Oset-Gasque, María Jesús
Publicado 2020

In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

por Więckowska, Anna, Szałaj, Natalia, Góral, Izabella, Bucki, Adam, Latacz, Gniewomir, Kiec-Kononowicz, Katarzyna, Bautista-Aguilera, Òscar. M., Romero, Alejandro, Ramos, Eva, Egea, Javier, Farré Alíns, Victor, González-Rodríguez, Águeda, López-Muñoz, Francisco, Chioua, Mourad, Marco-Contelles, José
Publicado 2020

Chromenones as Multineurotargeting Inhibitors of Human Enzymes

por Lemke, Carina, Christmann, Joscha, Yin, Jiafei, Alonso, José M., Serrano, Estefanía, Chioua, Mourad, Ismaili, Lhassane, Martínez-Grau, María Angeles, Beadle, Christopher D., Vetman, Tatiana, Dato, Florian M., Bartz, Ulrike, Elsinghorst, Paul W., Pietsch, Markus, Müller, Christa E., Iriepa, Isabel, Wille, Timo, Marco-Contelles, José, Gütschow, Michael
Publicado 2019

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

por Knez, Damijan, Diez-Iriepa, Daniel, Chioua, Mourad, Gottinger, Andrea, Denic, Milica, Chantegreil, Fabien, Nachon, Florian, Brazzolotto, Xavier, Skrzypczak-Wiercioch, Anna, Meden, Anže, Pišlar, Anja, Kos, Janko, Žakelj, Simon, Stojan, Jure, Sałat, Kinga, Serrano, Julia, Fernández, Ana Patricia, Sánchez-García, Aitana, Martínez-Murillo, Ricardo, Binda, Claudia, López-Muñoz, Francisco, Gobec, Stanislav, Marco-Contelles, José
Publicado 2023