Screening and in vitro antiviral assessment of small molecules against fluorescent protein-expressing Bunyamwera virus in a cell-based assay using high-content imaging

por ter Horst, Sebastiaan, Chiu, Winston, Neyts, Johan, Rocha-Pereira, Joana
Publicado 2021

Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern

por Vangeel, Laura, Chiu, Winston, De Jonghe, Steven, Maes, Piet, Slechten, Bram, Raymenants, Joren, André, Emmanuel, Leyssen, Pieter, Neyts, Johan, Jochmans, Dirk
Publicado 2022

YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge

por Lemmens, Viktor, Kelchtermans, Lara, Debaveye, Sarah, Chiu, Winston, Vercruysse, Thomas, Ma, Ji, Thibaut, Hendrik Jan, Neyts, Johan, Sanchez-Felipe, Lorena, Dallmeier, Kai
Publicado 2023

Development of a robust and convenient dual-reporter high-throughput screening assay for SARS-CoV-2 antiviral drug discovery

por Chiu, Winston, Schepers, Joost, Francken, Thibault, Vangeel, Laura, Abbasi, Kayvan, Jochmans, Dirk, De Jonghe, Steven, Thibaut, Hendrik Jan, Thiel, Volker, Neyts, Johan, Laporte, Manon, Leyssen, Pieter
Publicado 2023

Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells

por Vanhoutte, Roeland, Barniol-Xicota, Marta, Chiu, Winston, Vangeel, Laura, Jochmans, Dirk, De Jonghe, Steven, Zidane, Hadeer, Barr, Haim M., London, Nir, Neyts, Johan, Verhelst, Steven H. L.
Publicado 2023

Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents

por Martinez-Gualda, Belén, Graus, Mirthe, Camps, Anita, Vanhulle, Emiel, Saul, Sirle, Azari, Siavash, Nhu Tran, Do Hoang, Vangeel, Laura, Chiu, Winston, Neyts, Johan, Schols, Dominique, Einav, Shirit, Vermeire, Kurt, De Jonghe, Steven
Publicado 2022

Synthesis, characterization, molecular docking, and anticancer activities of new 1,3,4-oxadiazole-5-fluorocytosine hybrid derivatives

por El Mansouri, Az-eddine, Lachhab, Saida, Oubella, Ali, Ahmad, Mehdi, Neyts, Johan, Jochmans, Dirk, Chiu, Winston, Vangeel, Laura, De Jonghe, Steven, Morjani, Hamid, Ali, Mustapha Ait, Zahouily, Mohamed, Sanghvi, Yogesh S., Lazrek, Hassan B.
Publicado 2022

Development and optimization of a high‐throughput screening assay for in vitro anti‐SARS‐CoV‐2 activity: Evaluation of 5676 Phase 1 Passed Structures

por Chiu, Winston, Verschueren, Lore, Van den Eynde, Christel , Buyck, Christophe, De Meyer, Sandra, Jochmans, Dirk, Bojkova, Denisa, Ciesek, Sandra, Cinatl, Jindrich, De Jonghe, Steven, Leyssen, Pieter, Neyts, Johan, Van Loock, Marnix, Van Damme, Ellen
Publicado 2022

Identification of Z-Tyr-Ala-CHN(2), a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2

por Doijen, Jordi, Temmerman, Koen, Van den Eynde, Christel, Diels, Annick, Van den Broeck, Nick, Van Gool, Michiel, Heo, Inha, Jaensch, Steffen, Zwaagstra, Marleen, Diosa Toro, Mayra, Chiu, Winston, De Jonghe, Steven, Leyssen, Pieter, Bojkova, Denisa, Ciesek, Sandra, Cinatl, Jindrich, Verschueren, Lore, Buyck, Christophe, Van Kuppeveld, Frank, Neyts, Johan, Van Loock, Marnix, Van Damme, Ellen
Publicado 2023

Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort

por Zaliani, Andrea, Vangeel, Laura, Reinshagen, Jeanette, Iaconis, Daniela, Kuzikov, Maria, Keminer, Oliver, Wolf, Markus, Ellinger, Bernhard, Esposito, Francesca, Corona, Angela, Tramontano, Enzo, Manelfi, Candida, Herzog, Katja, Jochmans, Dirk, De Jonghe, Steven, Chiu, Winston, Francken, Thibault, Schepers, Joost, Collard, Caroline, Abbasi, Kayvan, Claussen, Carsten, Summa, Vincenzo, Beccari, Andrea R., Neyts, Johan, Gribbon, Philip, Leyssen, Pieter
Publicado 2022

Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects

por Saul, Sirle, Karim, Marwah, Ghita, Luca, Huang, Pei-Tzu, Chiu, Winston, Durán, Verónica, Lo, Chieh-Wen, Kumar, Sathish, Bhalla, Nishank, Leyssen, Pieter, Alem, Farhang, Boghdeh, Niloufar A., Tran, Do H.N., Cohen, Courtney A., Brown, Jacquelyn A., Huie, Kathleen E., Tindle, Courtney, Sibai, Mamdouh, Ye, Chengjin, Khalil, Ahmed Magdy, Chiem, Kevin, Martinez-Sobrido, Luis, Dye, John M., Pinsky, Benjamin A., Ghosh, Pradipta, Das, Soumita, Solow-Cordero, David E., Jin, Jing, Wikswo, John P., Jochmans, Dirk, Neyts, Johan, De Jonghe, Steven, Narayanan, Aarthi, Einav, Shirit
Publicado 2023

Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial

por Liesenborghs, Laurens, Spriet, Isabel, Jochmans, Dirk, Belmans, Ann, Gyselinck, Iwein, Teuwen, Laure-Anne, ter Horst, Sebastiaan, Dreesen, Erwin, Geukens, Tatjana, Engelen, Matthias M., Landeloos, Ewout, Geldhof, Vincent, Ceunen, Helga, Debaveye, Barbara, Vandenberk, Bert, Van der Linden, Lorenz, Jacobs, Sofie, Langendries, Lana, Boudewijns, Robbert, Do, Thuc Nguyen Dan, Chiu, Winston, Wang, Xinyu, Zhang, Xin, Weynand, Birgit, Vanassche, Thomas, Devos, Timothy, Meyfroidt, Geert, Janssens, Wim, Vos, Robin, Vermeersch, Pieter, Wauters, Joost, Verbeke, Geert, De Munter, Paul, Kaptein, Suzanne J.F., Rocha-Pereira, Joana, Delang, Leen, Van Wijngaerden, Eric, Neyts, Johan, Verhamme, Peter
Publicado 2021

Corrigendum to “itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens”

por Liesenborghs, Laurens, Spriet, Isabel, Jochmans, Dirk, Belmans, Ann, Gyselinck, Iwein, Teuwen, Laure-Anne, ter Horst, Sebastiaan, Dreesen, Erwin, Geukens, Tatjana, Engelen, Matthias M., Landeloos, Ewout, Geldhof, Vincent, Ceunen, Helga, Debaveye, Barbara, Vandenberk, Bert, Van der Linden, Lorenz, Jacobs, Sofie, Langendries, Lana, Boudewijns, Robbert, Dan Do, Thuc Nguyen, Chiu, Winston, Wang, Xinyu, Zhang, Xin, Weynand, Birgit, Vanassche, Thomas, Devos, Timothy, Meyfroidt, Geert, Janssens, Wim, Vos, Robin, Vermeersch, Pieter, Wauters, Joost, Verbeke, Geert, De Munter, Paul, Kaptein, Suzanne J.F., Rocha-Pereira, Joana, Delang, Leen, Van Wijngaerden, Eric, Neyts, Johan, Verhamme, Peter
Publicado 2021

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

por Boudewijns, Robbert, Thibaut, Hendrik Jan, Kaptein, Suzanne J. F., Li, Rong, Vergote, Valentijn, Seldeslachts, Laura, Van Weyenbergh, Johan, De Keyzer, Carolien, Bervoets, Lindsey, Sharma, Sapna, Liesenborghs, Laurens, Ma, Ji, Jansen, Sander, Van Looveren, Dominique, Vercruysse, Thomas, Wang, Xinyu, Jochmans, Dirk, Martens, Erik, Roose, Kenny, De Vlieger, Dorien, Schepens, Bert, Van Buyten, Tina, Jacobs, Sofie, Liu, Yanan, Martí-Carreras, Joan, Vanmechelen, Bert, Wawina-Bokalanga, Tony, Delang, Leen, Rocha-Pereira, Joana, Coelmont, Lotte, Chiu, Winston, Leyssen, Pieter, Heylen, Elisabeth, Schols, Dominique, Wang, Lanjiao, Close, Lila, Matthijnssens, Jelle, Van Ranst, Marc, Compernolle, Veerle, Schramm, Georg, Van Laere, Koen, Saelens, Xavier, Callewaert, Nico, Opdenakker, Ghislain, Maes, Piet, Weynand, Birgit, Cawthorne, Christopher, Vande Velde, Greetje, Wang, Zhongde, Neyts, Johan, Dallmeier, Kai
Publicado 2020