A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment

por Chiu, Ya-Jen, Teng, Yu-Shan, Chen, Chiung-Mei, Sun, Ying-Chieh, Hsieh-Li, Hsiu Mei, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen
Publicado 2023

Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protei...

por Lin, Te-Hsien, Chang, Kuo-Hsuan, Chiu, Ya-Jen, Weng, Zheng-Kui, Sun, Ying-Chieh, Lin, Wenwei, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Publicado 2022

Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer’s disease cell and mouse models for neuroprotection and cognitive improvement

por Chiu, Ya-Jen, Lin, Chih-Hsin, Lee, Ming-Chung, Hsieh-Li, Hsiu Mei, Chen, Chiung-Mei, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen
Publicado 2021

Novel TRKB agonists activate TRKB and downstream ERK and AKT signaling to protect Aβ-GFP SH-SY5Y cells against Aβ toxicity

por Chiu, Ya-Jen, Lin, Te-Hsien, Chang, Kuo-Hsuan, Lin, Wenwei, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan, Chen, Chiung-Mei, Sun, Ying-Chieh, Lee-Chen, Guey-Jen
Publicado 2022

Using ΔK280 Tau(RD) Folding Reporter Cells to Screen TRKB Agonists as Alzheimer’s Disease Treatment Strategy

por Weng, Zheng-Kui, Lin, Te-Hsien, Chang, Kuo-Hsuan, Chiu, Ya-Jen, Lin, Chih-Hsin, Tseng, Pei-Hsuan, Sun, Ying-Chieh, Lin, Wenwei, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Publicado 2023

Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation

por Chiu, Ya-Jen, Lin, Shu-An, Chen, Wan-Ling, Lin, Te-Hsien, Lin, Chih-Hsin, Yao, Ching-Fa, Lin, Wenwei, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Publicado 2020

Multi-Target Effects of Novel Synthetic Coumarin Derivatives Protecting Aβ-GFP SH-SY5Y Cells against Aβ Toxicity

por Huang, Ching-Chia, Chang, Kuo-Hsuan, Chiu, Ya-Jen, Chen, Yi-Ru, Lung, Tsai-Hui, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan, Sun, Ying-Chieh, Chen, Chiung-Mei, Lin, Wenwei, Lee-Chen, Guey-Jen
Publicado 2021

Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson’s Disease

por Chiu, Ya-Jen, Lin, Chih-Hsin, Lin, Chung-Yin, Yang, Pei-Ning, Lo, Yen-Shi, Chen, Yu-Chieh, Chen, Chiung-Mei, Wu, Yih-Ru, Yao, Ching-Fa, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen
Publicado 2023

Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2H-Chromen-2-One Activates CREB-Mediated Neuroprotection in Aβ and Tau Cell Model...

por Chiu, Ya-Jen, Lin, Te-Hsien, Chen, Chiung-Mei, Lin, Chih-Hsin, Teng, Yu-Shan, Lin, Chung-Yin, Sun, Ying-Chieh, Hsieh-Li, Hsiu Mei, Su, Ming-Tsan, Lee-Chen, Guey-Jen, Lin, Wenwei, Chang, Kuo-Hsuan
Publicado 2021

Exploration of multi‐target effects of 3‐benzoyl‐5‐hydroxychromen‐2‐one in Alzheimer’s disease cell and mouse models

por Lin, Te‐Hsien, Chiu, Ya‐Jen, Lin, Chih‐Hsin, Lin, Chung‐Yin, Chao, Chih‐Ying, Chen, Yu‐Chieh, Yang, Shu‐Mei, Lin, Wenwei, Mei Hsieh‐Li, Hsiu, Wu, Yih‐Ru, Chang, Kuo‐Hsuan, Lee‐Chen, Guey‐Jen, Chen, Chiung‐Mei
Publicado 2020