Targeted multi-epitope switching enables straightforward positive/negative selection of CAR T cells

por Mosti, Laura, Langner, Lukas M., Chmielewski, Kay O., Arbuthnot, Patrick, Alzubi, Jamal, Cathomen, Toni
Publicado 2021

Genome Editing With TALEN, CRISPR-Cas9 and CRISPR-Cas12a in Combination With AAV6 Homology Donor Restores T Cell Function for XLP

por Houghton, Benjamin C., Panchal, Neelam, Haas, Simone A., Chmielewski, Kay O., Hildenbeutel, Markus, Whittaker, Thomas, Mussolino, Claudio, Cathomen, Toni, Thrasher, Adrian J, Booth, Claire
Publicado 2022

A novel Cas9 fusion protein promotes targeted genome editing with reduced mutational burden in primary human cells

por Carusillo, Antonio, Haider, Sibtain, Schäfer, Raul, Rhiel, Manuel, Türk, Daniel, Chmielewski, Kay O, Klermund, Julia, Mosti, Laura, Andrieux, Geoffroy, Schäfer, Richard, Cornu, Tatjana I, Cathomen, Toni, Mussolino, Claudio
Publicado 2023

Automated generation of gene-edited CAR T cells at clinical scale

por Alzubi, Jamal, Lock, Dominik, Rhiel, Manuel, Schmitz, Sabrina, Wild, Stefan, Mussolino, Claudio, Hildenbeutel, Markus, Brandes, Caroline, Rositzka, Julia, Lennartz, Simon, Haas, Simone A., Chmielewski, Kay O., Schaser, Thomas, Kaiser, Andrew, Cathomen, Toni, Cornu, Tatjana I.
Publicado 2020