Extensible combinatorial CRISPR screening in mammalian cells

por Zhou, Peng, Wan, Yuk Kei, Chan, Becky K.C., Choi, Gigi C.G., Wong, Alan S.L.
Publicado 2021

High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies

por Cao, Jicong, Novoa, Eva Maria, Zhang, Zhizhuo, Chen, William C. W., Liu, Dianbo, Choi, Gigi C. G., Wong, Alan S. L., Wehrspaun, Claudia, Kellis, Manolis, Lu, Timothy K.
Publicado 2021

A synthetic transcription platform for programmable gene expression in mammalian cells

por Chen, William C. W., Gaidukov, Leonid, Lai, Yong, Wu, Ming-Ru, Cao, Jicong, Gutbrod, Michael J., Choi, Gigi C. G., Utomo, Rachel P., Chen, Ying-Chou, Wroblewska, Liliana, Kellis, Manolis, Zhang, Lin, Weiss, Ron, Lu, Timothy K.
Publicado 2022

Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities

por Thean, Dawn G. L., Chu, Hoi Yee, Fong, John H. C., Chan, Becky K. C., Zhou, Peng, Kwok, Cynthia C. S., Chan, Yee Man, Mak, Silvia Y. L., Choi, Gigi C. G., Ho, Joshua W. K., Zheng, Zongli, Wong, Alan S. L.
Publicado 2022

High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination

por Yuen, Chaya T L, Thean, Dawn G L, Chan, Becky K C, Zhou, Peng, Kwok, Cynthia C S, Chu, Hoi Yee, Cheung, Maggie S H, Wang, Bei, Chan, Yee Man, Mak, Silvia Y L, Leung, Anskar Y, Choi, Gigi C G, Zheng, Zongli, Wong, Alan S L
Publicado 2022