LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease

por Chang, Eunice Eun Seo, Ho, Philip Wing-Lok, Liu, Hui-Fang, Pang, Shirley Yin-Yu, Leung, Chi-Ting, Malki, Yasine, Choi, Zoe Yuen-Kiu, Ramsden, David Boyer, Ho, Shu-Leong
Publicado 2022

Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2(R1441G) mice

por Liu, Huifang, Ho, Philip Wing-Lok, Leung, Chi-Ting, Pang, Shirley Yin-Yu, Chang, Eunice Eun Seo, Choi, Zoe Yuen-Kiu, Kung, Michelle Hiu-Wai, Ramsden, David Boyer, Ho, Shu-Leong
Publicado 2020

Transcriptional Regulation of the Synaptic Vesicle Protein Synaptogyrin-3 (SYNGR3) Gene: The Effects of NURR1 on Its Expression

por Li, Lingfei, Ho, Philip Wing-Lok, Liu, Huifang, Pang, Shirley Yin-Yu, Chang, Eunice Eun-Seo, Choi, Zoe Yuen-Kiu, Malki, Yasine, Kung, Michelle Hiu-Wai, Ramsden, David Boyer, Ho, Shu-Leong
Publicado 2022

In vivo overexpression of synaptogyrin‐3 promotes striatal synaptic dopamine uptake in LRRK2(R1441G) mutant mouse model of Parkinson's disease

por Ho, Philip Wing‐Lok, Li, Lingfei, Liu, Hui‐Fang, Choi, Zoe Yuen‐Kiu, Chang, Eunice Eun Seo, Pang, Shirley Yin‐Yu, Malki, Yasine, Leung, Chi‐Ting, Kung, Michelle Hiu‐Wai, Ramsden, David Boyer, Ho, Shu‐Leong
Publicado 2023

LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease

por Pang, Shirley Yin-Yu, Lo, Rachel Cheuk Nam, Ho, Philip Wing-Lok, Liu, Hui-Fang, Chang, Eunice Eun Seo, Leung, Chi-Ting, Malki, Yasine, Choi, Zoe Yuen-Kiu, Wong, Wing Yan, Kung, Michelle Hiu-Wai, Ramsden, David Boyer, Ho, Shu-Leong
Publicado 2022

Long-term inhibition of mutant LRRK2 hyper-kinase activity reduced mouse brain α-synuclein oligomers without adverse effects

por Ho, Philip Wing-Lok, Chang, Eunice Eun-Seo, Leung, Chi-Ting, Liu, Huifang, Malki, Yasine, Pang, Shirley Yin-Yu, Choi, Zoe Yuen-Kiu, Liang, Yingmin, Lai, Weng Seng, Ruan, Yuefei, Leung, Kenneth Mei-Yee, Yung, Susan, Mak, Judith Choi-Wo, Kung, Michelle Hiu-Wai, Ramsden, David B., Ho, Shu-Leong
Publicado 2022