Isobenzofuranone derivative JVPH3, an inhibitor of L. donovani topoisomerase II, disrupts mitochondrial architecture in trypanosomatid parasites

por Chowdhury, Somenath Roy, Godinho, Joseane Lima Prado, Vinayagam, Jayaraman, Zuma, Aline Araujo, Silva, Sara Teixeira De Macedo, Jaisankar, Parasuraman, Rodrigues, Juliany Cola Fernandes, De Souza, Wanderley, Majumder, Hemanta K.
Publicado 2018

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

por Teuscher, Kevin B., Chowdhury, Somenath, Meyers, Kenneth M., Tian, Jianhua, Sai, Jiqing, Van Meveren, Mayme, South, Taylor M., Sensintaffar, John L., Rietz, Tyson A., Goswami, Soumita, Wang, Jing, Grieb, Brian C., Lorey, Shelly L., Howard, Gregory C., Liu, Qi, Moore, William J., Stott, Gordon M., Tansey, William P., Lee, Taekyu, Fesik, Stephen W.
Publicado 2022