Efficacy of c-Met inhibitor for advanced prostate cancer

por Tu, William H, Zhu, Chunfang, Clark, Curtis, Christensen, James G, Sun, Zijie
Publicado 2010

Enhanced efficacy of sitravatinib in metastatic models of antiangiogenic therapy resistance

por Dolan, Melissa, Mastri, Michalis, Tracz, Amanda, Christensen, James G., Chatta, Gurkamal, Ebos, John M. L.
Publicado 2019

PHA665752, a small-molecule inhibitor of c-Met, inhibits hepatocyte growth factor-stimulated migration and proliferation of c-Met-positive neuroblastoma cells

por Crosswell, Hal E, Dasgupta, Anindya, Alvarado, Carlos S, Watt, Tanya, Christensen, James G, De, Pradip, Durden, Donald L, Findley, Harry W
Publicado 2009

A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation

por Lee, Nathan V., Lira, Maruja E., Pavlicek, Adam, Ye, Jingjing, Buckman, Dana, Bagrodia, Shubha, Srinivasa, Sreesha P., Zhao, Yongjun, Aparicio, Samuel, Rejto, Paul A., Christensen, James G., Ching, Keith A.
Publicado 2012

Correction: A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation

por Lee, Nathan V., Lira, Maruja E., Pavlicek, Adam, Ye, Jingjing, Buckman, Dana, Bagrodia, Shubha, Srinivasa, Sreesha P., Zhao, Yongjun, Aparicio, Samuel, Rejto, Paul A., Christensen, James G., Ching, Keith A.
Publicado 2012

Intracranial Efficacy of Adagrasib in Patients From the KRYSTAL-1 Trial With KRAS(G12C)-Mutated Non–Small-Cell Lung Cancer Who Have Untreated CNS Metastases

por Negrao, Marcelo V., Spira, Alexander I., Heist, Rebecca S., Jänne, Pasi A., Pacheco, Jose M., Weiss, Jared, Gadgeel, Shirish M., Velastegui, Karen, Yang, Wenjing, Der-Torossian, Hirak, Christensen, James G., Sabari, Joshua K.
Publicado 2023

Targeting MET and EGFR crosstalk signaling in triple-negative breast cancers

por Linklater, Erik S., Tovar, Elizabeth A., Essenburg, Curt J., Turner, Lisa, Madaj, Zachary, Winn, Mary E., Melnik, Marianne K., Korkaya, Hasan, Maroun, Christiane R., Christensen, James G., Steensma, Matthew R., Boerner, Julie L., Graveel, Carrie R.
Publicado 2016

Fragment optimization and elaboration strategies – the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits

por Smith, Christopher R., Kulyk, Svitlana, Ahmad, Misbha Ud Din, Arkhipova, Valentina, Christensen, James G., Gunn, Robin J., Ivetac, Anthony, Ketcham, John M., Kuehler, Jon, Lawson, J. David, Thomas, Nicole C., Wang, Xiaolun, Marx, Matthew A.
Publicado 2022

First-in-Human Phase I/IB Dose-Finding Study of Adagrasib (MRTX849) in Patients With Advanced KRAS(G12C) Solid Tumors (KRYSTAL-1)

por Ou, Sai-Hong Ignatius, Jänne, Pasi A., Leal, Ticiana A., Rybkin, Igor I., Sabari, Joshua K., Barve, Minal A., Bazhenova, Lyudmila, Johnson, Melissa L., Velastegui, Karen L., Cilliers, Cornelius, Christensen, James G., Yan, Xiaohong, Chao, Richard C., Papadopoulos, Kyriakos P.
Publicado 2022

Combined Inhibition of SHP2 and CXCR1/2 Promotes Antitumor T-cell Response in NSCLC

por Tang, Kwan Ho, Li, Shuai, Khodadadi-Jamayran, Alireza, Jen, Jayu, Han, Han, Guidry, Kayla, Chen, Ting, Hao, Yuan, Fedele, Carmine, Zebala, John A., Maeda, Dean Y., Christensen, James G., Olson, Peter, Athanas, Argus, Loomis, Cynthia A., Tsirigos, Aristotelis, Wong, Kwok-Kin, Neel, Benjamin G.
Publicado 2022

Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRAS(G12C)-Mutant Non–Small Cell Lung Cancer

por Sabari, Joshua K., Velcheti, Vamsidhar, Shimizu, Kazuhide, Strickland, Matthew R., Heist, Rebecca S., Singh, Mohini, Nayyar, Naema, Giobbie-Hurder, Anita, Digumarthy, Subba R., Gainor, Justin F., Rajan, Anant P., Nieblas-Bedolla, Edwin, Burns, Aaron C., Hallin, Jill, Olson, Peter, Christensen, James G., Kurz, Sylvia C., Brastianos, Priscilla K., Wakimoto, Hiroaki
Publicado 2022

Mocetinostat for patients with previously treated, locally advanced/metastatic urothelial carcinoma and inactivating alterations of acetyltransferase genes

por Grivas, Petros, Mortazavi, Amir, Picus, Joel, Hahn, Noah M., Milowsky, Matthew I., Hart, Lowell L., Alva, Ajjai, Bellmunt, Joaquim, Pal, Sumanta K., Bambury, Richard M., O’Donnell, Peter H., Gupta, Sumati, Guancial, Elizabeth A., Sonpavde, Guru P., Faltaos, Demiana, Potvin, Diane, Christensen, James G., Chao, Richard C., Rosenberg, Jonathan E.
Publicado 2018

Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity

por Tang, Zhe, Jiang, Shan, Du, Runlei, Petri, Edward T., El-Telbany, Ahmed, Chan, Perry S.O., Kijima, Takashi, Dietrich, Sascha, Matsui, Kaoru, Kobayashi, Masashi, Sasada, Shinji, Okamoto, Norio, Suzuki, Hideaki, Kawahara, Kunimitsu, Iwasaki, Teruo, Nakagawa, Katsuhiro, Kawase, Ichiro, Christensen, James G., Hirashima, Tomonori, Halmos, Balazs, Salgia, Ravi, Boggon, Titus J., Kern, Jeffrey A., Ma, Patrick C.
Publicado 2008

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

por Kentsis, Alex, Reed, Casie, Rice, Kim L., Sanda, Takaomi, Rodig, Scott J., Tholouli, Eleni, Christie, Amanda, Valk, Peter J.M., Delwel, Ruud, Ngo, Vu, Kutok, Jeffery L., Dahlberg, Suzanne E., Moreau, Lisa A., Byers, Richard J., Christensen, James G., Woude, George Vande, Licht, Jonathan D., Kung, Andrew L., Staudt, Louis M., Look, A. Thomas
Publicado 2012

Efficacy of a Small-Molecule Inhibitor of Kras(G12D) in Immunocompetent Models of Pancreatic Cancer

por Kemp, Samantha B., Cheng, Noah, Markosyan, Nune, Sor, Rina, Kim, Il-Kyu, Hallin, Jill, Shoush, Jason, Quinones, Liz, Brown, Natalie V., Bassett, Jared B., Joshi, Nikhil, Yuan, Salina, Smith, Molly, Vostrejs, William P., Perez-Vale, Kia Z., Kahn, Benjamin, Mo, Feiyan, Donahue, Timothy R., Radu, Caius G., Clendenin, Cynthia, Christensen, James G., Vonderheide, Robert H., Stanger, Ben Z.
Publicado 2023

Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction

por Ketcham, John M., Haling, Jacob, Khare, Shilpi, Bowcut, Vickie, Briere, David M., Burns, Aaron C., Gunn, Robin J., Ivetac, Anthony, Kuehler, Jon, Kulyk, Svitlana, Laguer, Jade, Lawson, J. David, Moya, Krystal, Nguyen, Natalie, Rahbaek, Lisa, Saechao, Barbara, Smith, Christopher R., Sudhakar, Niranjan, Thomas, Nicole C., Vegar, Laura, Vanderpool, Darin, Wang, Xiaolun, Yan, Larry, Olson, Peter, Christensen, James G., Marx, Matthew A.
Publicado 2022

MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer

por Engstrom, Lars D., Aranda, Ruth, Waters, Laura, Moya, Krystal, Bowcut, Vickie, Vegar, Laura, Trinh, David, Hebbert, Allan, Smith, Christopher R., Kulyk, Svitlana, Lawson, J. David, He, Leo, Hover, Laura D., Fernandez-Banet, Julio, Hallin, Jill, Vanderpool, Darin, Briere, David M., Blaj, Alice, Marx, Matthew A., Rodon, Jordi, Offin, Michael, Arbour, Kathryn C., Johnson, Melissa L., Kwiatkowski, David J., Jänne, Pasi A., Haddox, Candace L., Papadopoulos, Kyriakos P., Henry, Jason T., Leventakos, Konstantinos, Christensen, James G., Shazer, Ronald, Olson, Peter
Publicado 2023

Molecular Characterization of Acquired Resistance to KRAS(G12C)–EGFR Inhibition in Colorectal Cancer

por Yaeger, Rona, Mezzadra, Riccardo, Sinopoli, Jenna, Bian, Yu, Marasco, Michelangelo, Kaplun, Esther, Gao, Yijun, Zhao, HuiYong, Paula, Arnaud Da Cruz, Zhu, Yingjie, Perez, Almudena Chaves, Chadalavada, Kalyani, Tse, Edison, Chowdhry, Sudhir, Bowker, Sydney, Chang, Qing, Qeriqi, Besnik, Weigelt, Britta, Nanjangud, Gouri J., Berger, Michael F., Der-Torossian, Hirak, Anderes, Kenna, Socci, Nicholas D., Shia, Jinru, Riely, Gregory J., Murciano-Goroff, Yonina R., Li, Bob T., Christensen, James G., Reis-Filho, Jorge S., Solit, David B., de Stanchina, Elisa, Lowe, Scott W., Rosen, Neal, Misale, Sandra
Publicado 2023