MAP4K4 and IL-6(+) Th17 cells play important roles in non-obese type 2 diabetes

por Chuang, Huai-Chia, Tan, Tse-Hua
Publicado 2017

MAP4K3/GLK in autoimmune disease, cancer and aging

por Chuang, Huai-Chia, Tan, Tse-Hua
Publicado 2019

MAP4K Family Kinases and DUSP Family Phosphatases in T-Cell Signaling and Systemic Lupus Erythematosus

por Chuang, Huai-Chia, Tan, Tse-Hua
Publicado 2019

ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification

por Wang, Chia-Wen, Chuang, Huai-Chia, Tan, Tse-Hua
Publicado 2023

Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability

por Chen, Hsueh-Fen, Chuang, Huai-Chia, Tan, Tse-Hua
Publicado 2019

Regulation of PKC-θ function by phosphorylation in T cell receptor signaling

por Wang, Xiaohong, Chuang, Huai-Chia, Li, Ju-Pi, Tan, Tse-Hua
Publicado 2012

GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease

por Chuang, Huai-Chia, Tsai, Ching-Yi, Hsueh, Chia-Hsin, Tan, Tse-Hua
Publicado 2018

Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation

por Yang, Chia-Yu, Chiu, Li-Li, Chang, Chih-Chi, Chuang, Huai-Chia, Tan, Tse-Hua
Publicado 2018

Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases

por Lai, Chih-Hsuan, Chang, Co-Chih, Chuang, Huai-Chia, Tan, Tse-Hua, Lyu, Ping-Chiang
Publicado 2020

Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis

por Chen, Ming-Han, Chuang, Huai-Chia, Yeh, Yi-Chen, Chou, Chung-Tei, Tan, Tse-Hua
Publicado 2023

Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients

por Chuang, Huai-Chia, Wang, Jun-Sing, Lee, I-Te, Sheu, Wayne H-H., Tan, Tse-Hua
Publicado 2016

RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis

por Peng, Hui-Yu, Liang, Yu-Chih, Tan, Tse-Hua, Chuang, Huai-Chia, Lin, Ying-Ju, Lin, Jung-Chun
Publicado 2018

MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation

por Chi, Jyun-Ni, Yang, Jhih-Yu, Hsueh, Chia-Hsin, Tsai, Ching-Yi, Chuang, Huai-Chia, Tan, Tse-Hua
Publicado 2022

DUSP6 Deficiency Attenuates Neurodegeneration after Global Cerebral Ischemia

por Weng, Yi-Chinn, Huang, Yu-Ting, Chiang, I-Chen, Chuang, Huai-Chia, Lee, Tsong-Hai, Tan, Tse-Hua, Chou, Wen-Hai
Publicado 2023

Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker

por Chen, Der-Yuan, Chuang, Huai-Chia, Lan, Joung-Liang, Chen, Yi-Ming, Hung, Wei-Ting, Lai, Kuo-Lung, Tan, Tse-Hua
Publicado 2012

GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer

por Hsu, Chung-Ping, Chuang, Huai-Chia, Lee, Ming-Ching, Tsou, Hsiao-Hui, Lee, Li-Wen, Li, Ju-Pi, Tan, Tse-Hua
Publicado 2016

Downregulation of the phosphatase JKAP/DUSP22 in T cells as a potential new biomarker of systemic lupus erythematosus nephritis

por Chuang, Huai-Chia, Chen, Yi-Ming, Hung, Wei-Ting, Li, Ju-Pi, Chen, Der-Yuan, Lan, Joung-Liang, Tan, Tse-Hua
Publicado 2016

AhR–ROR-γt complex is a therapeutic target for MAP4K3/GLK(high)IL-17A(high) subpopulation of systemic lupus erythematosus

por Chuang, Huai-Chia, Chen, Yi-Ming, Chen, Ming-Han, Hung, Wei-Ting, Yang, Huang-Yu, Tseng, Yang-Hao, Tan, Tse-Hua
Publicado 2019

Genomic sequencing and functional analyses identify MAP4K3/GLK germline and somatic variants associated with systemic lupus erythematosus

por Chuang, Huai-Chia, Hung, Wei-Ting, Chen, Yi-Ming, Hsu, Pu-Ming, Yen, Jeng-Hsien, Lan, Joung-Liang, Tan, Tse-Hua
Publicado 2022

Induction of Interferon‐γ and Tissue Inflammation by Overexpression of Eosinophil Cationic Protein in T Cells and Exosomes

por Chuang, Huai‐Chia, Chen, Ming‐Han, Chen, Yi‐Ming, Ciou, Yi‐Ru, Hsueh, Chia‐Hsin, Tsai, Ching‐Yi, Tan, Tse‐Hua
Publicado 2021