POLE proofreading mutation, immune response and prognosis in endometrial cancer

por van Gool, Inge C., Bosse, Tjalling, Church, David N.
Publicado 2015

Automated assessment of CD8(+) T-lymphocytes and stroma fractions complement conventional staging of colorectal cancer

por Jiang, Dan, Hveem, Tarjei S., Glaire, Mark, Church, David N., Kerr, David J., Yang, Li, Danielsen, Håvard E.
Publicado 2021

Discordant prognosis of mismatch repair deficiency in colorectal and endometrial cancer reflects variation in antitumour immune response and immune escape

por Glaire, Mark A, Ryan, Neil AJ, Ijsselsteijn, Marieke E, Kedzierska, Katarzyna, Obolenski, Sofia, Ali, Reem, Crosbie, Emma J, Bosse, Tjalling, de Miranda, Noel FCC, Church, David N
Publicado 2022

CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

por Komdeur, Fenne L., Prins, Thalina M., van de Wall, Stephanie, Plat, Annechien, Wisman, G. Bea A., Hollema, Harry, Daemen, Toos, Church, David N., de Bruyn, Marco, Nijman, Hans W.
Publicado 2017

Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis

por Brown, Matthew, Leon, Alicia, Kedzierska, Katarzyna, Moore, Charlotte, Belnoue‐Davis, Hayley L, Flach, Susanne, Lydon, John P, DeMayo, Francesco J, Lewis, Annabelle, Bosse, Tjalling, Tomlinson, Ian, Church, David N
Publicado 2023

Histological and Somatic Mutational Profiles of Mismatch Repair Deficient Endometrial Tumours of Different Aetiologies

por Ryan, Neil A. J., Walker, Thomas D. J., Bolton, James, ter Haar, Natalja, Van Wezel, Tom, Glaire, Mark A., Church, David N., Evans, D. Gareth, Bosse, Tjalling, Crosbie, Emma J.
Publicado 2021

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

por Church, David N., Briggs, Sarah E.W., Palles, Claire, Domingo, Enric, Kearsey, Stephen J., Grimes, Jonathon M., Gorman, Maggie, Martin, Lynn, Howarth, Kimberley M., Hodgson, Shirley V., Kaur, Kulvinder, Taylor, Jenny, Tomlinson, Ian P.M.
Publicado 2013

Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain...

por Lau, David, Kalaitzaki, Eleftheria, Church, David N, Pandha, Hardev, Tomlinson, Ian, Annels, Nicola, Gerlinger, Marco, Sclafani, Francesco, Smith, Gillian, Begum, Ruwaida, Crux, Richard, Gillbanks, Angela, Wordsworth, Sarah, Chau, Ian, Starling, Naureen, Cunningham, David, Dhillon, Tony
Publicado 2020

Interpretation of somatic POLE mutations in endometrial carcinoma

por León‐Castillo, Alicia, Britton, Heidi, McConechy, Melissa K, McAlpine, Jessica N, Nout, Remi, Kommoss, Stefan, Brucker, Sara Y, Carlson, Joseph W, Epstein, Elisabeth, Rau, Tilman T, Bosse, Tjalling, Church, David N, Gilks, C Blake
Publicado 2020

Tumour-infiltrating CD8(+) lymphocytes and colorectal cancer recurrence by tumour and nodal stage

por Glaire, Mark A., Domingo, Enric, Sveen, Anita, Bruun, Jarle, Nesbakken, Arild, Nicholson, George, Novelli, Marco, Lawson, Kay, Oukrif, Dahmane, Kildal, Wanja, Danielsen, Havard E., Kerr, Rachel, Kerr, David, Tomlinson, Ian, Lothe, Ragnhild A., Church, David N.
Publicado 2019

Correction: Tumour-infiltrating CD8(+) lymphocytes and colorectal cancer recurrence by tumour and nodal stage

por Glaire, Mark A., Domingo, Enric, Sveen, Anita, Bruun, Jarle, Nesbakken, Arild, Nicholson, George, Novelli, Marco, Lawson, Kay, Oukrif, Dahmane, Kildal, Wanja, Danielsen, Havard E., Kerr, Rachel, Kerr, David, Tomlinson, Ian, Lothe, Ragnhild A., Church, David N.
Publicado 2019

Prediction of relapse-free survival according to adjuvant chemotherapy and regulator of chromosome condensation 2 (RCC2) expression in colorectal cancer

por Bergsland, Christian H, Bruun, Jarle, Guren, Marianne G, Svindland, Aud, Bjørnslett, Merete, Smeby, Jørgen, Hektoen, Merete, Kolberg, Matthias, Domingo, Enric, Pellinen, Teijo, Tomlinson, Ian, Kerr, David, Church, David N, Nesbakken, Arild, Sveen, Anita, Lothe, Ragnhild A
Publicado 2020

Immunological profiling of molecularly classified high-risk endometrial cancers identifies POLE-mutant and microsatellite unstable carcinomas as candidates for checkpoint inhibitio...

por Eggink, Florine A., Van Gool, Inge C., Leary, Alexandra, Pollock, Pamela M., Crosbie, Emma J., Mileshkin, Linda, Jordanova, Ekaterina S., Adam, Julien, Freeman-Mills, Luke, Church, David N., Creutzberg, Carien L., De Bruyn, Marco, Nijman, Hans W., Bosse, Tjalling
Publicado 2016

Non-Canonical Activin A Signaling Stimulates Context-Dependent and Cellular-Specific Outcomes in CRC to Promote Tumor Cell Migration and Immune Tolerance

por Wiley, Mark B., Bauer, Jessica, Mehrotra, Kunaal, Zessner-Spitzenberg, Jasmin, Kolics, Zoe, Cheng, Wenxuan, Castellanos, Karla, Nash, Michael G., Gui, Xianyong, Kone, Lyonell, Maker, Ajay V., Qiao, Guilin, Reddi, Deepti, Church, David N., Kerr, Rachel S., Kerr, David J., Grippo, Paul J., Jung, Barbara
Publicado 2023

Prognostic Significance of POLE Proofreading Mutations in Endometrial Cancer

por Church, David N., Stelloo, Ellen, Nout, Remi A., Valtcheva, Nadejda, Depreeuw, Jeroen, ter Haar, Natalja, Noske, Aurelia, Amant, Frederic, Tomlinson, Ian P. M., Wild, Peter J., Lambrechts, Diether, Jürgenliemk-Schulz, Ina M., Jobsen, Jan J., Smit, Vincent T. H. B. M., Creutzberg, Carien L., Bosse, Tjalling
Publicado 2014

Clinicopathological and molecular characterisation of ‘multiple‐classifier’ endometrial carcinomas

por León‐Castillo, Alicia, Gilvazquez, Ester, Nout, Remi, Smit, Vincent THBM, McAlpine, Jessica N, McConechy, Melissa, Kommoss, Stefan, Brucker, Sara Y, Carlson, Joseph W, Epstein, Elisabeth, Rau, Tilman T, Soslow, Robert A, Ganesan, Raji, Matias‐Guiu, Xavier, Oliva, Esther, Harrison, Beth T, Church, David N, Gilks, C Blake, Bosse, Tjalling
Publicado 2020

Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer

por Roseweir, Antonia K, Park, James H, Hoorn, Sanne ten, Powell, Arfon GMT, Aherne, Susan, Roxburgh, Campbell SD, McMillan, Donald C, Horgan, Paul G, Ryan, Elizabeth, Sheahan, Kieran, Vermeulen, Louis, Paul, James, Harkin, Andrea, Graham, Janet, Sansom, Owen, Church, David N, Tomlinson, Ian, Saunders, Mark, Iveson, Tim J, Edwards, Joanne
Publicado 2020

The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer

por Alexander, Peter G., Roseweir, Antonia K., Pennel, Kathryn A. F., van Wyk, Hester C., Powell, Arfon G. M. T., McMillan, Donald C., Horgan, Paul G., Kelly, Caroline, Hay, Jennifer, Sansom, Owen, Harkin, Andrea, Roxburgh, Campbell S. D., Graham, Janet, Church, David N., Tomlinson, Ian, Saunders, Mark, Iveson, Tim J., Edwards, Joanne, Park, James H.
Publicado 2020

Promises and challenges of adoptive T-cell therapies for solid tumours

por Morotti, Matteo, Albukhari, Ashwag, Alsaadi, Abdulkhaliq, Artibani, Mara, Brenton, James D., Curbishley, Stuart M., Dong, Tao, Dustin, Michael L., Hu, Zhiyuan, McGranahan, Nicholas, Miller, Martin L., Santana-Gonzalez, Laura, Seymour, Leonard W., Shi, Tingyan, Van Loo, Peter, Yau, Christopher, White, Helen, Wietek, Nina, Church, David N., Wedge, David C., Ahmed, Ahmed A.
Publicado 2021

Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden...

por Temko, Daniel, Van Gool, Inge C, Rayner, Emily, Glaire, Mark, Makino, Seiko, Brown, Matthew, Chegwidden, Laura, Palles, Claire, Depreeuw, Jeroen, Beggs, Andrew, Stathopoulou, Chaido, Mason, John, Baker, Ann‐Marie, Williams, Marc, Cerundolo, Vincenzo, Rei, Margarida, Taylor, Jenny C, Schuh, Anna, Ahmed, Ahmed, Amant, Frédéric, Lambrechts, Diether, Smit, Vincent THBM, Bosse, Tjalling, Graham, Trevor A, Church, David N, Tomlinson, Ian
Publicado 2018