The Challenge of Interpreting Alanine Aminotransferase Elevations in Clinical Trials of New Drug Candidates

por Church, Rachel J., Watkins, Paul B.
Publicado 2020

Cannabidiol and Abnormal Liver Chemistries in Healthy Adults: Results of a Phase I Clinical Trial

por Watkins, Paul B., Church, Rachel J., Li, Jie, Knappertz, Volker
Publicado 2020

Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse

por Church, Rachel J., Schomaker, Shelli J., Eaddy, J. Scott, Boucher, Germaine G., Kreeger, John M., Aubrecht, Jiri, Watkins, Paul B.
Publicado 2020

Gremlin1 plays a key role in kidney development and renal fibrosis

por Church, Rachel H., Ali, Imran, Tate, Mitchel, Lavin, Deborah, Krishnakumar, Arjun, Kok, Helena M., Hombrebueno, Jose R., Dunne, Philip D., Bingham, Victoria, Goldschmeding, Roel, Martin, Finian, Brazil, Derek P.
Publicado 2017

Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix

por Robinson, Emma, Cassidy, Roslyn S., Tate, Mitchel, Zhao, Youyou, Lockhart, Samuel, Calderwood, Danielle, Church, Rachel, McGahon, Mary K., Brazil, Derek P., McDermott, Barbara J., Green, Brian D., Grieve, David J.
Publicado 2015

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

por Woodhead, Jeffrey L., Brock, William J., Roth, Sharin E., Shoaf, Susan E., Brouwer, Kim L.R., Church, Rachel, Grammatopoulos, Tom N., Stiles, Linsey, Siler, Scott Q., Howell, Brett A., Mosedale, Merrie, Watkins, Paul B., Shoda, Lisl K.M.
Publicado 2017

Next‐Generation DILI Biomarkers: Prioritization of Biomarkers for Qualification and Best Practices for Biospecimen Collection in Drug Development

por Roth, Sharin E., Avigan, Mark I., Bourdet, David, Brott, David, Church, Rachel, Dash, Ajit, Keller, Douglas, Sherratt, Philip, Watkins, Paul B., Westcott‐Baker, Lucas, Lentini, Silvia, Merz, Michael, Ramaiah, Lila, Ramaiah, Shashi K., Stanley, Ann Marie, Marcinak, John
Publicado 2019

miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia

por Guduric-Fuchs, Jasenka, Pedrini, Edoardo, Lechner, Judith, Chambers, Sarah E.J., O’Neill, Christina L., Mendes Lopes de Melo, Joana, Pathak, Varun, Church, Rachel H., McKeown, Stuart, Bojdo, James, Mcloughlin, Kiran J., Stitt, Alan W., Medina, Reinhold J.
Publicado 2021