Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance

por Churchill, Grant C., Strupp, Michael, Galione, Antony, Platt, Frances M.
Publicado 2020

Examination of betahistine bioavailability in combination with the monoamine oxidase B inhibitor, selegiline, in humans—a non-randomized, single-sequence, two-period titration, ope...

por Strupp, Michael, Churchill, Grant C., Naumann, Ivonne, Mansmann, Ulrich, Al Tawil, Amani, Golentsova, Anastasia, Goldschagg, Nicolina
Publicado 2023

The Calcium-mobilizing Messenger Nicotinic Acid Adenine Dinucleotide Phosphate Participates in Sperm Activation by Mediating the Acrosome Reaction

por Vasudevan, Sridhar R., Lewis, Alexander M., Chan, Jennifer W., Machin, Claire L., Sinha, Debroshi, Galione, Antony, Churchill, Grant C.
Publicado 2010

Bidirectional Ca(2+) signaling occurs between the endoplasmic reticulum and acidic organelles

por Morgan, Anthony J., Davis, Lianne C., Wagner, Siegfried K.T.Y., Lewis, Alexander M., Parrington, John, Churchill, Grant C., Galione, Antony
Publicado 2013

Discovery of Novel GPVI Receptor Antagonists by Structure-Based Repurposing

por Taylor, Lewis, Vasudevan, Sridhar R., Jones, Chris I., Gibbins, Jonathan M., Churchill, Grant C., Campbell, R. Duncan, Coxon, Carmen H.
Publicado 2014

Acetylation turns leucine into a drug by membrane transporter switching

por Churchill, Grant C., Strupp, Michael, Factor, Cailley, Bremova-Ertl, Tatiana, Factor, Mallory, Patterson, Marc C., Platt, Frances M., Galione, Antony
Publicado 2021

Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A

por Fernández, Belén, Fdez, Elena, Gómez-Suaga, Patricia, Gil, Fernando, Molina-Villalba, Isabel, Ferrer, Isidro, Patel, Sandip, Churchill, Grant C., Hilfiker, Sabine
Publicado 2016

Iron-induced cytotoxicity mediated by endolysosomal TRPML1 channels is reverted by TFEB

por Fernández, Belén, Olmedo, Pablo, Gil, Fernando, Fdez, Elena, Naaldijk, Yahaira, Rivero-Ríos, Pilar, Bracher, Franz, Grimm, Christian, Churchill, Grant C., Hilfiker, Sabine
Publicado 2022

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

por Gómez-Suaga, Patricia, Luzón-Toro, Berta, Churamani, Dev, Zhang, Ling, Bloor-Young, Duncan, Patel, Sandip, Woodman, Philip G., Churchill, Grant C., Hilfiker, Sabine
Publicado 2012

Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate

por Lewis, Alexander M., Masgrau, Roser, Vasudevan, Sridhar R., Yamasaki, Michiko, O’Neill, John S., Garnham, Clive, James, Kristin, Macdonald, Andrew, Ziegler, Mathias, Galione, Antony, Churchill, Grant C.
Publicado 2007

Effects of the potential lithium-mimetic, ebselen, on brain neurochemistry: a magnetic resonance spectroscopy study at 7 tesla

por Masaki, Charles, Sharpley, Ann L., Godlewska, Beata R., Berrington, Adam, Hashimoto, Tasuku, Singh, Nisha, Vasudevan, Sridhar R., Emir, Uzay E., Churchill, Grant C., Cowen, Philip J.
Publicado 2016

PS54. Effects of the potential lithium-mimetic, ebselen, on brain neurochemistry: A magnetic resonance spectroscopy study at 7 Tesla

por Masaki, Charles, Sharpley, Ann L., Godlewska, Beata R, Berrington, Adam, Hashimoto, Tasuku, Singh, Nisha, Vasudevan, Sridhar R., Emir, Uzay E., Churchill, Grant C., Cowen, Philip J.
Publicado 2016

Identification of a chemical probe for NAADP by virtual screening

por Naylor, Edmund, Arredouani, Abdelilah, Vasudevan, Sridhar R., Lewis, Alexander M., Parkesh, Raman, Mizote, Akiko, Rosen, Daniel, Thomas, Justyn M., Izumi, Minoru, Ganesan, A., Galione, Antony, Churchill, Grant C.
Publicado 2009

A safe lithium mimetic for bipolar disorder

por Singh, Nisha, Halliday, Amy C., Thomas, Justyn M., Kuznetsova, Olga, Baldwin, Rhiannon, Woon, Esther C. Y., Aley, Parvinder K., Antoniadou, Ivi, Sharp, Trevor, Vasudevan, Sridhar R., Churchill, Grant C.
Publicado 2013

TPC2 Is a Novel NAADP-sensitive Ca(2+) Release Channel, Operating as a Dual Sensor of Luminal pH and Ca(2+)

por Pitt, Samantha J., Funnell, Tim M., Sitsapesan, Mano, Venturi, Elisa, Rietdorf, Katja, Ruas, Margarida, Ganesan, A., Gosain, Rajendra, Churchill, Grant C., Zhu, Michael X., Parrington, John, Galione, Antony, Sitsapesan, Rebecca
Publicado 2010

Endoplasmic reticulum and lysosomal Ca(2+) stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts

por Kilpatrick, Bethan S., Magalhaes, Joana, Beavan, Michelle S., McNeill, Alisdair, Gegg, Matthew E., Cleeter, Michael W.J., Bloor-Young, Duncan, Churchill, Grant C., Duchen, Michael R., Schapira, Anthony H., Patel, Sandip
Publicado 2016

Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing

por Masaki, Charles, Sharpley, Ann L., Cooper, Charlotte M., Godlewska, Beata R., Singh, Nisha, Vasudevan, Sridhar R., Harmer, Catherine J., Churchill, Grant C., Sharp, Trevor, Rogers, Robert D., Cowen, Philip J.
Publicado 2016

NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing

por Davis, Lianne C., Morgan, Anthony J., Chen, Ji-Li, Snead, Charlotte M., Bloor-Young, Duncan, Shenderov, Eugene, Stanton-Humphreys, Megan N., Conway, Stuart J., Churchill, Grant C., Parrington, John, Cerundolo, Vincenzo, Galione, Antony
Publicado 2012

Defective platelet function in Niemann‐Pick disease type C1

por Chen, Oscar C. W., Colaco, Alexandria, Davis, Lianne C., Kiskin, Fedir N., Farhat, Nicole Y., Speak, Anneliese O., Smith, David A., Morris, Lauren, Eden, Emily, Tynan, Patricia, Churchill, Grant C., Galione, Antony, Porter, Forbes D., Platt, Frances M.
Publicado 2020

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Sig...

por Capel, Rebecca A., Bolton, Emma L., Lin, Wee K., Aston, Daniel, Wang, Yanwen, Liu, Wei, Wang, Xin, Burton, Rebecca-Ann B., Bloor-Young, Duncan, Shade, Kai-Ting, Ruas, Margarida, Parrington, John, Churchill, Grant C., Lei, Ming, Galione, Antony, Terrar, Derek A.
Publicado 2015