Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells

por Dettmer, Rabea, Niwolik, Isabell, Cirksena, Karsten, Yoshimoto, Toshiaki, Tang, Yadi, Mehmeti, Ilir, Gurgul-Convey, Ewa, Naujok, Ortwin
Publicado 2022

FGF2 Inhibits Early Pancreatic Lineage Specification during Differentiation of Human Embryonic Stem Cells

por Dettmer, Rabea, Cirksena, Karsten, Münchhoff, Julia, Kresse, Jasmin, Diekmann, Ulf, Niwolik, Isabell, Buettner, Falk F. R., Naujok, Ortwin
Publicado 2020

Genetic BACH1 deficiency alters mitochondrial function and increases NLRP3 inflammasome activation in mouse macrophages

por Pradhan, Pooja, Vijayan, Vijith, Cirksena, Karsten, Buettner, Falk F.R., Igarashi, Kazuhiko, Motterlini, Roberto, Foresti, Roberta, Immenschuh, Stephan
Publicado 2022

The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity

por Carriquí-Madroñal, Belén, Sheldon, Julie, Duven, Mara, Stegmann, Cora, Cirksena, Karsten, Wyler, Emanuel, Zapatero-Belinchón, Francisco J., Vondran, Florian W. R., Gerold, Gisa
Publicado 2023

The C-Mannosylome of Human Induced Pluripotent Stem Cells Implies a Role for ADAMTS16 C-Mannosylation in Eye Development

por Cirksena, Karsten, Hütte, Hermann J., Shcherbakova, Aleksandra, Thumberger, Thomas, Sakson, Roman, Weiss, Stefan, Jensen, Lars Riff, Friedrich, Alina, Todt, Daniel, Kuss, Andreas W., Ruppert, Thomas, Wittbrodt, Joachim, Bakker, Hans, Buettner, Falk F.R.
Publicado 2021